wemptronics
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User ID: 95
wemptronics
1d ago
Well, who's going to invent this amazing life-saving radical biotech? Not you, you were busy having your body frozen. Or busy working out how to build the refrigerators.
It's a fair bet that humans will continue to be interested in modes of immortality, life extension, or techno-necromancy in 50, 100, and 1000 years from now. New refrigerants don't help crack the nut, no, but if Bryan Johnson's hero dose inspired shitpost grants him an epiphany in 50 years those refrigerants might enable a lot more people to benefit if the stewardship role of cryo works out.
From the LW comments:
It's not set up yet but we are broadly going to model it after Alcor's long-term patient care fund. Non profit. They survived for decades; no sense in changing something that isn't broken.
Aurelia also explained that they plan to encourage people to keep Alcor packages since Nectome doesn't plan to do any out of state retrieval. If you can, you fly to Oregon and get the best possible chance. If you can't, you've still got your standard freezer package. This is clever way to enter the small market, but one that is past due on innovation. Based on the tone of the LW commentariat this is very early days, so we are discussing start-up vaporware with proof-of-concept.
What about cryonics? What's new? Where else would I read new cryonics if not a pitch on LessWrong?
"Traditional" cryonics requires a crisis response to a customer's death. A person dies, people are alerted, and a plan is carried out to evacuate a body to administer cryogoo-- glycerol. That body is transferred to cold storage and suspended in liquid nitrogen with a barrier of one fancy cask. The liquid nitrogen creates extreme temperatures for preservation, around -192C, a temperature that comes with risks-- human tissue kept at -192C tends to be very fragile. Another pressing issue is that the goo filling-to-freezer process takes time, and bodies stop all kinds of maintenance after death. Dying with imperfect preservation means if someone did find a way to upload your brain to the Matrix, or reanimate your corpse, unless they've fully cracked the mysteries of regenerative medicine the experience may not be to your liking.
Why is this this culture war? Nectome's new method offers a workaround to the last problem: kill yourself.
The result is a protocol that my company, Nectome, has spent the past ten years developing. After years of experiments in the lab and in the field, learning about the complexity of end-of-life biology, and after refining our protocol to make it robust and repeatable for real people in real-world clinical settings, we are now ready. We've developed a whole-body, whole-brain, human end-of-life preservation protocol based on neuroscience first principles. We are capable of preserving every synapse and almost every protein, lipid, and nucleic acid throughout the whole body. Brains are connectomically traceable after preservation[1]. Our preservation is so comprehensive that current neuroscience theories imply it preserves all relevant information necessary for future restoration of a preserved person.
Nectome wants you to have the option to end your life so they can preserve your bits, bobs, and neuronal structure, increasing the chance you emerge intact down the line. You can read a slightly more detailed overview in this PDF from Nectome with citations. You can compare it to the big brand-name cryonics company in the US named Alcor. Alcor has facilities located in Arizona, which is a state with cheap land, no hurricanes, low humidity, and a favorable regulatory environment. Good things for long term groundskeeping. Unlike Alcor, Nectome plans to set up shop in Oregon. Also unlike Alcor, Nectome clarifies they will host no brains in jars with holistic, rather than trope filled, process.
We preserve the whole body, including the brain, at nanoscale, subsynaptic detail. We are capable of preserving every neuron and every synapse in the brain, and almost every protein, lipid, and nucleic acid within each cell and throughout the entire body is held in place by molecular crosslinks.
The business pitch relies on the fact that Oregon has MAID, colloquially known as assisted suicide. Rather than keep cells frozen in place with extremely low temperatures, Nectome's goo formula does more work to stabilize structures chemically, which allows a moderate preservation temperature at -32C. This process must be completed immediately following death. So if a client can plan around, or potentially induce, a state recognized terminal illness, they can purchase a flight to the state of Oregon, end their life, and receive the latest greatest chance at... something in the future. Don't want to miss the singularity or omnipotent medicine? No cryonics company promises anything like that, they usually only agree to look after your frozen bits for as long as is feasible.
About that, Nectome's founder is also involved with Eon Systems, a company currently working on brain emulators. They generated a viral story with apparent progress on a fly connectome earlier this month. Specific claims of hype are contested, but progress on mapping, building, and simulating brains seems real. Much has been written on MAID slippery slopes, but it seems we already have a current legal avenue to test a "freeze me" future with an upload waiting room. Take the upload to Elon Musk's Afterlife, which is a RuneScape clone by the way, replete with a procedurally generated non-stop feed of his greatest twitter hits at your finger tips into eternity, or until transcendent beings awaken you.
With so many sci-fi fantasies filling up the horizon, why not kill yourself and wait awhile? What did you think transhumanism meant, anyway? vibes? papers? essays?
Yeah, I don't reckon you need to buy a bridge if you're swimming across.
I'll be erring on the side of patience as a virtue irrespective of any other considerations, thank you very much. Sense of identity maybe not so much, but my willingness can change in a traffic jam.
Did I infer correctly that Nectome's crosslinking method is intended for the simulator end game, and fundamentally further or mutually exclusive with the "maybe someday medicine gets really good" revival hope of traditional cryo? The LW discussion didn't seem to talk about it as a pivot. I guess if you're in the market for cryo it's more like hedging and that's why it is presented and discussed this way.
This was in part a bait post for the thoughts of local enthusiast and medicine man, cheers!
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