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PaperclipPerfector  6mo ago (text post)   32198 thread views

Culture War Roundup for the week of June 23, 2025

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I think the reality of the situation is that we still do not understand, outside of some special basic cases, in the slightest how genes correspond to phenotypes, beyond a sort of general sense that should make it clear to us that we do not even have the vocabulary and abstractions to describe such an understanding if it were handed down to us by divine inspiration. I'd expect the simplest nontrivial gene-IQ relationships to look something like "the presence of sequence A slightly reduces the frequency sequence B is transcribed into proteins in neurons when they contain between x and y concentration of transcripts of sequence C, so in individuals whose genetic makeup causes the concentration to converge to that band in their frontal lobe, they get slightly thicker myelin sheaths in that part of their brain, which might make you more smart except if it also happens in the temporal lobe in which case you just turn out schizo". Do we have analysis techniques that would pick this sort of thing up? My impression is that expecting our current ones to do so is comparable to trying to debug slowdowns in complex distributed systems by big-data search for correlations between system performance and the frequency (possibly joint) of individual words in source code.

To introduce a juicier culture war angle, the confusion about the discrepancy, i.e. the expectation that techniques like GWAS would pick up the heritability we expect from twin studies, seems to be motivated by the usual prior that surely the top-of-the-line techniques that the community of experts in a given area are excited about must at least be somewhat good (see also expectation that architects have good taste in architecture, artists have good taste in art, or social justice researchers can correctly identify and redress injustice in society). If you expect geneticists to not be meaningfully competent at genetics in absolute terms, then "geneticists could not find the mechanism of heritability that we are fairly certain exists" is an unsurprising outcome.

To introduce a juicier culture war angle, the confusion about the discrepancy, i.e. the expectation that techniques like GWAS would pick up the heritability we expect from twin studies, seems to be motivated by the usual prior that surely the top-of-the-line techniques that the community of experts in a given area are excited about must at least be somewhat good

I believe this is not incorrect take. There are ton of methodological assumptions researcher makes when they run a GWAS study, you could make many of them differently, and it would still be genome-wide. I doubt we have seen the latest and best GWAS yet.

One must hand it out to GWAS that become the hot method of choice because it was impressive how well it appears to predict other stuff (depression, schizophrenia, breast cancer, other disease). I don't know if there ever was twin studies of coronary artery disease, which are not such a hot CW topic as educational attainment, but I have not heard of debates "GWAS doesn't predict coronary artery disease as well as twin studies".

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