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Notes -
Depends what you mean by "traditional", but not really. I would describe viral vector vaccines as more tested than mRNA vaccines, but they still haven't made much end-use impact. What I would personally describe as a traditional vaccine would be any of:
Attenuated pathogens, such as the MMR vaccine.
Inactivated pathogens, such as the old whole-cell pertussis vaccine.
Antigen and adjuvant, such as the newer acellular pertussis vaccine.
This may also be a marker for something even weirder (maybe worse) going on - IgG4 can be associated with immune tolerance and anti-inflammatory responses. If additional boosts skew even further, this could be a real concern.
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