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PaperclipPerfector  21hr ago (text post)   712 thread views

Small-Scale Question Sunday for August 16, 2026

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The overall observed decline in CRC [colorectal cancer] mortality was 26% for 1975–2000. The model predicted that, with only changes in risk factors, CRC mortality would have decreased by 9%, explaining 35% of the observed mortality decline. Screening was estimated to have decreased mortality by another 14%, explaining 53% of the mortality reduction, while treatment added another 3% decline, explaining the final 12% of the observed decline in CRC mortality.

These modeling results strongly suggest that approximately 50% of the decline in CRC incidence and mortality between1975 and 2000 could be due to CRC screening. We have now used a similar analysis for the time period up to 2010 and again estimated that CRC screening likely accounts for about 50% of the reduction in CRC mortality over the more recent period.

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