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Notes -
Right now gene therapy is mostly focused on severe monogenic disease, either crippling or lethal disease, where the high price and potential risk are worth it.
When it comes to health, such as heart health or lifespan, in general, between { strongly negative, weakly negative, neutral, weakly positive, strongly positive } gene variants (as subjectively defined - I am not making an "objective" ranking), I would expect relatively few { strongly positive } to exist. { weakly negative, weakly positive } will be somewhat difficult for the industry to detect, and if each gene editing operation incurs risk and expenses, are likely not to be targeted until later. { strongly negative } should be easier to detect, has a stronger moral and political case to support it, and is likely to be funded by governments for insurance-like reasons in combination with political reasons.
I think we should expect a lifting of the left tail of the health distribution, rather than much of a boost at the high end. There are natural limiting factors in that the more edits someone makes, the farther away the kid is from being "their" kid, so it's likely that relatively few people would pursue something as radical as DNA synthesis, at least around 2050. Beyond then, it's more difficult to predict. There may also be ideological manias around 2050 that might distort the response.
I'm mostly thinking about it's probably going to be the rich and tech-friendly who use it most, who I'd expect to be higher IQ on average. You're probably right, though, that it would work best to stop the strongly deleterious, but I assume with statistics and with the current cheapness of getting genetic data, it's probably pretty doable to get more information.
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