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Chrisprattalpharaptr

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User ID: 1864

Chrisprattalpharaptr

Ave Imperaptor

1 follower   follows 1 user   joined 2022 November 15 02:36:44 UTC

					

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User ID: 1864

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To which I respond... yes. That's exactly right. Suppose ICE actually deports enough illegals to cause significant shortages in farming, roofing, factory work, construction, etc. Suppose that Trump's tariffs contract the economy to the point that lazy unemployed 20-30 year old men find it much more difficult to comfortably survive off their standard combination of day trading, intermittent gig work, and freeloading off their families. Suppose it gets to the point that their only option is to begin filling the vacancies left by the deportations. Isn't that just... wonderful? Isn't that exactly what Trump's base voted for? Isn't that, quite literally, how you make America great again?

The dream held by parents around the world is not 'I have done backbreaking labor roofing the houses, tilling the fields and manning the production lines - I hope that my child will live the same life,' it is 'I have done backbreaking labor roofing the houses, tilling the fields and manning the production lines so that my child doesn't have to.' Rather than grubbing around in the dirt with a hoe, we built massive tractors and combines to the work of dozens? Hundreds? of men. And more cynically, we outsourced the production lines to Bangladesh and roofing houses to illegals. But boomers and their children got to put on their white collars and push papers around in an office all day! Or, you know, become neets and shitpost on 4chan.

Tell me, do Chinese people tell their children to dream of a job on the production line or do they force them to study 20 hours a day for the gaokao in hopes of escaping a life of manual labor to do the white collar jobs that you sneer at? The future is not retvrning to backbreaking labor, but forging a new path that avoids both the perils of neetdom and the grievances of the dispossessed. The future lies in recognizing our love of zero-sum status games and squaring that with a world where there's fewer and fewer high-status jobs to go around.

A nation, a culture, a race that does not provide for itself, should go without. This, I imagine, is one of the core ethical commitments that separates MAGA from its opponents.

Really...? When is the last time you heard MAGA supporters agitating for cuts to welfare and entitlements because those who do not provide for themselves, should go without? When has Trump ever supported anything resembling what you just said? The core ethical commitment that separates MAGA from the rest of the country is a revanchist bent to make the libs/globalists/elites suffer as they have. The reaction to the supreme court striking down Roe v. Wade wasn't jubilation about saving the unborn (although I did hear of some Catholic circles where this was the case), it was gloating about how arrogant Hillary and RBJ were in assuming that the arc of history was inevitably bending their way as they girlbossed their way to grinding the deplorables beneath their high heels. The reaction to DOGE isn't that cutting government spending would improve the union (see: all the arguments regarding the magnitude of the spending cut versus the actual federal budget), it was joy at the suffering of entitled, lazy government bureaucrats and globalists who care more about HIV in Africa than fentanyl abuse in the rust belt.

Whether the anger is justified is a whole other conversation, but consider this: If MAGA were forced to choose between 1) a debatably prosperous country where libs in New York and San Francisco flourished via tech/healthcare/finance and MAGA strongholds stagnated or 2) crushing the 'globalist agenda' and doing to those industries what was done to manufacturing, with questionable benefit to MAGA strongholds, which do you think they would choose?

If you take away the animus for the libs, the MAGA coalition collapses. You see it here where there is largely consensus against any kind of woke topic, but bitter arguments around the Russian invasion of Ukraine or the tariffs.

Arranged marriage white edition: the ugliest white dude gets headhunted by a controlling Asian woman who keeps him on a leash. He is overjoyed to find his fetish match. Happy ending.

I've been laughing at this for the last 10 minutes. WMAF couples are by far the dominant demographic in my immediate social circle.

Last April, you said:

Israel cannot survive unless Iran is destroyed now. There’s basically no scenario where the tit for tat won’t escalate into an unending front of infinite Iranian resources in Lebanon, Gaza, and/or the Golan Heights,as well as constant back and forth air and rocket fire.

And Iran can't be destroyed unless the US implements a draft of millions of Americans which would start a civil war and end the US.

...

So after this move, basically the only thing that can save them from a death spiral is a major US invasion, which the US would lose militarily without a draft...

Such A draft that would cause a violent revolution/civil war in the US... A civil war that would quickly become ww3 as Chinese and Russian Assets egged on the US collapse and the US military tried to reply in kind.

...

This is probably WW3 Friends. stock up now. End of the age.

Do you think this was wrong? If so, how did you learn/update from the last 7 months?

You have also repeatedly predicted WWIII as well as a major civil war with >1,000,000 dead in the United States following the election. While you still have 50 odd days left for some assassination scenario or Biden to nuke Moscow, do you think the lack of violent protests (or serious protests at all, really) or the general acceptance of Trump's victory mean this was also a bad prediction? Is the point to be edgy clickbait or...do you genuinely believe the things you write?

Neurological science is the better way to get at the human mind, not woo.

Hoo boy, do I have some bad news for you.

Molecular biology works fine for messing around with neurons in a tissue culture dish, but it provides remarkably little insight into a complex system like the brain. It's good for saying if I knock this gene out we lose action potentials, therefore this gene is at least required for that process (how it fits in with the 1000s of other genes involved in that process? Often much less clear).

Anytime you zoom out to a broader systems-level view, or anytime you disconnect your work from some ground truth we're inevitably left with woo. If it weren't for clinical trials enforcing some measure of 'woo' colliding with reality, probably the entirety of the life sciences wouldn't be that far off from phrenology-level fMRI experiments.

Anyways. Sure, the social sciences are a waste of time from a scientific standpoint. I'd argue they have other uses, but that's a bit beside my point - the majority of research in the life sciences as a whole is largely subjective bullshit. It's always a shock to fresh students coming in how arbitrary and ineffective a lot of what we do is when they're used to textbooks having all the answers and making science out to be some dispassionate, objective endeavor.

Pretty pathetic. I thought he genuinely cared about the rule of law and his legacy, as you point out, but it seems I've been insufficiently cynical. I suppose politicians will only be honest insofar as voters can punish them for defection.

In conclusion, for the moderates and centrists: Your signal is jammed, and only extremism will be boosted on either twitter or bluesky.

So why use it at all? Why use any social media aside from linkedin and a facebook/whatsapp account for messaging? There seems to be a broad agreement in the rat-diaspora that social media is a plague that wrecks attention spans, leads to skyrocketing teenage mental health issues and erodes any kind of political discourse, yet people still seem to use it.

Just read books and build community in meatspace instead of using Twitter/Bluesky. Whatever benefit you derive probably isn't worth the exposure to memes and toxic ragebait.

This post is about Tariffs, again, lest I be accused of burying the lede. Just read the last two paragraphs if you don't enjoy window dressing.

China tightened regulations on real estate developers in 2020. Xi Jinping stated 'houses are for living, not speculation.' Ghost cities, huge numbers of Chinese citizens owning multiple houses as investment vehicles, I assume you're all familiar with the stories after five years of news stories and discussion. Economists and western commentators largely agreed that the policies were A Really Bad Idea due to the ensuing chaos and meltdown in property prices.

To which I have to say ...what? They said they wanted to reduce housing costs! What did you think that would look like? How else are you going to do it? And what do you think it would look like to 'make housing more affordable' in the USA? If the YIMBYs and neoliberals abundance socialists get their way, home prices are going to tank here too. This is a good thing! Maybe there's some Chestertonian benefit to the upwards spiral of housing costs, but this here's a fence I'm ready to take a torch to.

Anyways, to inch closer to the issue at hand - I have to confess that I had some tepid enthusiasm for Trump returning to office. Despite it all, I'm still an Elon stan and I thought some of the Dogemaxxers might have cogent arguments. I had some hope for racking up some China tariffs, eating bitterness for a few years and coming out the other end as a cohesive autarkical bloc of NATO + AUKUS + Japan + South Korea + anyone not named Putin or Jinping we can convince to join the squad. Setting aside my disappointments with Trump 2.0...

I'm utterly perplexed by the dialogue around tariffs? I can remember breathless fearmongering about shortages, empty shelves, inflation all spring. People on reddit posted invoices where what used to be a 10,000$ order from China was now over 50,000$. And yet...none of this chaos has come to pass? As far as I can tell, TACO is somewhat responsible, but also, average US tariff rates are just over 50% on Chinese goods?. Is it all TACO? If 50% tariffs have been painless, do you expect me to believe that 100% tariffs will truly be apocalyptic to the US economy? Do any of the firmly anti-tariff crowd have an explanation or prediction to make?

And on the other side, I fully expect victory laps and crowing about 4D chess from the 'Trump BTFOs retarded soyboy economics ExPeRtS crowd' again, but if the tariffs are painless and everyone is still buying cheap shit from China, aren't we losing??? Isn't the inflation, the spike in prices and the empty shelves the point of this whole exercise? Why are you promising people it will be painless, rather than YesChadding and telling them that the pain is the goal? You can have affordable housing when you're willing to accept that your own home will depreciate in value, and you can have low-skill manufacturing in your country when you're willing to accept higher prices for your goods. Eat bitterness with a smile on your face. Tell your daughter she only gets two dolls instead of 30 this Christmas because communism uncle Jerry with the high school degree needs a better job.

Proposal: Everyone else writes their own versions of your viewpoint, complete with what they think you do for a living, asl, etc.

What follows was learned over a decade ago in microbiology class and may be out of date.

HIV exclusively infects cells of the immune system through a handful of receptors, none of which are expressed on the mucosa of the anus/vaginal tissue. As a consequence, it needs to penetrate multiple layers of mucus and epithelial tissue before it can reach a cell that it can productively (use to produce more viral particles) infect. Anal sex generates microtears in the mucosa much more readily than vaginal sex and provides more opportunities for the virus to reach the bloodstream/immune tissues. There was also some speculation about 'sensor' immune cells that reach into the epithelium that may also act as a route for infection, but I'm skeptical.

What shocked me in that class was just how rare transmission was; you can see the numbers in the table morgenland linked. Made me think that you have to be either extremely unlucky, extremely promiscuous or just stupid/desperate enough to share needles to get infected.

And the flip side of this is that as soon as a worker is negative EV or whatever the appropriate metric is, they're liable to be laid off. This is just the equilibrium where neither party can trust the other and there is at will employment. I imagine economists like it and would say that the employee who moves and gets a raise or a company laying off unproductive workers is more efficient, and what do I know, maybe they're right.

I was chatting with a Japanese employee of a large company with offices in both Japan and the US. He says that rather than layoffs, they get put on 'career improvement plans.' In his case, it involved completely retraining his specialty and moving his family to the US, but he kept his job and stayed at the same company. We could probably have this situation if we wanted, but I'm unsure it's actually superior.

When will the AI penny drop?

Amara's law seems to apply here: everyone overestimates the short-term effects and underestimates the long-term effects of a new technology. On the one hand, many clearly intelligent people with enormously more domain specific knowledge than me. On the other hand, I have a naturally skeptical nature (particularly when VCs and startups have an obvious conflict of interest in feeding said hype) and find arguments from Freddie deBoer and Tyler Cowen convincing:

That, I am convinced, lies at the heart of the AI debate – the tacit but intense desire to escape now. What both those predicting utopia and those predicting apocalypse are absolutely certain of is that the arrival of these systems, what they take to be the dawn of the AI era, means now is over. They are, above and beyond all things, millenarians. In common with all millenarians they yearn for a future in which some vast force sweeps away the ordinary and frees them from the dreadful accumulation of minutes that constitutes human life. The particular valence of whether AI will bring paradise or extermination is ultimately irrelevant; each is a species of escapism, a grasping around for a parachute. Thus the most interesting questions in the study of AI in the 21st century are not matters of technology or cognitive science or economics, but of eschatology.

The null hypothesis when someone claims the imminence of the eschaton carries a lot of weight. I dream of a utopian transhumanist future (or fear paperclipping) as much as you do, I'm just skeptical of your claims that you can build God in any meaningful way. In my domain, AI is so far away from meaningfully impacting any of the questions I care about that I despair you'll be able to do what you claim even assuming we solve alignment and manage some kind of semi-hard takeoff scenario. And, no offense, but the Gell-Mann amnesia hits pretty hard when I read shit like this:

It emails out some instructions to one of those labs that'll synthesize DNA and synthesize proteins from the DNA and get some proteins mailed to a hapless human somewhere who gets paid a bunch of money to mix together some stuff they got in the mail in a file. Like, smart people will not do this for any sum of money. Many people are not smart. Builds the ribosome, but the ribosome that builds things out of covalently bonded diamondoid instead of proteins folding up and held together by Van der Waals forces, builds tiny diamondoid bacteria. The diamondoid bacteria replicate using atmospheric carbon, hydrogen, oxygen, nitrogen, and sunlight. And a couple of days later, everybody on earth falls over dead in the same second.

I've lost the exact podcast link, but Tyler Cowen has a schtick where he digs into what exactly 10% YOY GDP growth would mean given the breakdown by sector of US GDP. Will it boost manufacturing? Frankly, I'm not interested in consooming more stuff. I don't want more healthcare or services, and I enjoy working. Most of what I do want is effectively zero-sum; real estate (large, more land, closer to the city, good school district) and a membership at the local country club might be nice, but how can AI growing GDP move the needle on goods that are valuable because of their exclusivity?

Are there measures of progress beyond GDP that are qualitative rather than quantifying dollars flowing around? I can imagine meaningful advances in healthcare (but see above) and self-driving cars (already on the way, seems unrelated to the eschaton) would be great. Don't see how you can replicate competitive school districts - I guess the AI hype man will say AI tutors will make school obsolete? Or choice property - I'd guess the AI hype man would say that self-driving officecars will enable people to live tens of miles outside the city center and/or make commuting obsolete?

I can believe that AI will wreak changes on the order of the industrial revolution in the medium-long term. I'm skeptical that you're building God, and that either paperclipping or immortality are in the cards in our lifetimes. I'd be willing to bet you that 5 and even 10 years from now I'll still be running and/or managing people who run experiments, with the largest threat to that future coming from 996 Chinese working for slave wages at government-subsidized companies wrecking the American biotech sector rather than oracular AI.

I've attached a reply from Gemini 2.5

Consider this a warning; keep posting AI slop and I'll have to put on my mod hat and punish you.

It uses patsies or useful idiots to assemble a novel pathogen with high virulence, high lethality, and minimal predromal symptoms with a lengthy incubation time. Maybe it find an existing pathogen in a Wuhan Immunology Lab closet, who knows. It arranges for this to be spread simultaneously from multiple sites...This doesn't require superhuman intelligence that's godlike. It just has to be very smart, very determined, patient, and willing to take risks. At no point does any technology that doesn't exist or plausibly can exist in the near future come into play.

Do you really think you can do that with existing technology? I'm not confident we've seriously tried to make a pathogen that can eradicate a species (mosquito gene drives? COVID expressing human prions, engineered so that they can't just drop the useless genes?) so it's difficult to estimate your odds of success. I can tell you the technology to make something 'with a lengthy incubation time and minimal predromal symptoms' does not exist today. You can't just take the 'lengthy incubation time gene' out of HIV and Frankenstein it together with the 'high virulence gene' from ebola and the 'high infectivity' gene from COVID. Ebola fatality rate is only 50%, and it's not like you can make it airborne, so...

Without spreading speculation about the best way to destroy humanity, I would guess that your odds of success with such an approach are fairly low. Your best bet is probably just releasing existing pathogens, maybe with some minimal modifications. I'm skeptical of your ability to make more than a blip in the world population. And now we're talking about something on par with what a really motivated and misanthropic terrorist could conceivably do if they were well-resourced.

I'm still voting against bombing the GPU clusters, and I'm still having children. We'll see in 20 years whether my paltry gentile IQ was a match for the big Yud, or whether he'll get to say I told you so for all eternity as the AI tortures us. I hope I at least get to be the well-endowed chimpanzee-man.

I am but a humble biologist, and know little of warfare, politics and economics. But I'm surprised to see nobody has mentioned that the majority of US aid to Ukraine was spent with US arms manufacturers. Many Trump supporters (or at least democrat-haters) bemoaned the atrophied state of US/European arms production when Russia was producing more shells than NATO per month. China can kick our ass in drone production. Setting aside all questions of morality (which I obviously find more compelling than your median Trump supporter), why not use the conflict in Ukraine as an opportunity to re-arm? So to answer your question...pretty much anything and everything that we can make that wouldn't enable Ukraine to steamroll the Russian army and march on Moscow. No NATO troops, no air support (just intel), no nuclear umbrella (for now).

As an aside, isn't domestic spending to onshore manufacturing a key goal of the Trump administration? Why the monomaniacal focus on tariffs and not industrial policy more broadly? And particularly tariffs on our allies...but I suppose that's a different discussion.

while the conversation about the current state has certainly been productive, it seems to me that rationalization on either side is always a failure mode, and the cure is predictions:

Indeed. I've seen you post half a dozen times here something along the lines of (and feel free to correct my paraphrasing): 'My model of the world is that the ingroup will consistently choose to harm the outgroup as much as possible. In 2020, protesters burned down billions of dollars worth of homes/businesses to harm the outgroup. When Red-tribe Kyle Rittenhouse tried to defend innocents he was attacked and then tried by the Blue-tribe Justice system that refused to prosecute the crimes of the rioters.

When the pandemic happened, Blue tribe health officials instituted draconian lockdowns that minimally impacted the white-collar laptop-class but wrecked Red tribe laborers and Red tribe parents.

My model of the world predicts these events perfectly! Do you have a better model, and if so, does it accurately predict the world?'

To which I would say, would your model predict:

  1. Trump wouldn't prosecute Hilary in 2016?
  2. The lack of major civil unrest, stochastic terrorism, or any major backlash to the repeal of Roe v. Wade aside from some Democratic electoral wins in 2022?
  3. The end of vaccine mandates in public and private spheres and the end of lockdowns?
  4. The utter lack of any major protests, civil unrest, or loss of faith in the electoral system after Trump beat Harris? (you want comments that aged like milk - look at the people who were claiming election fraud the morning of November 5th and even through that evening)
  5. The utter defeat of abolish the police and any of the George Floyd era movements?
  6. The lack of significant stochastic terrorism (remember the breathless doomposting about how easy it would be for disaffected lone wolf Red Tribers to blow power substations and other critical infrastructure?) through a year of electoral campaigning and the actual election?

To be clear, I doubt I could have predicted these events with any accuracy. But my observation is that you couldn't have done that either. If you want to prove me wrong, make some concrete predictions about the next four years. Will Trump incarcerate Biden or some other major democrat? Trump assassinated by an activist? Significant uptick in lone wolf attacks? World War III?

The only thing your model has going for it is that nobody pays attention to things that don't happen, even when that's the critical evidence against your argument. But whenever something controversial happens, you pop up and point towards the big flashing sign saying 'EVERYTHING SUCKS.' It's the same sensationalism that governs journalists, wrapped in a Bayesian/rationalist worldview.

Biden family's alleged corruption has evolved over time, here and in the broader public, and the specific events and disclosures that have shaped that conversation. My perception is that many of the arguments made to defend Biden, his family, and the conduct of the investigations into their activities have aged exceedingly poorly.

I admit to being disappointed in Biden, the pardon is deplorable and shouldn't have happened. I remain unconvinced that Joe Biden is particularly corrupt (...pardon notwithstanding), and I'm skeptical that Hunter is particularly corrupt by the standards of DC.

In particular, it seems to me that this saga has been an excellent example of a common pattern of group behavior wherein the facts, as they emerge, consistently break against the tribal narrative. This pattern seems to me to be a good indicator of entrenched tribalism attempting to deny reality, and likewise a good demonstration of the limits and shortcomings of that tribalism, which should guide us to a better understanding of how the Culture War is likely to play out.

One tribal narrative was that Biden was corrupt and abused his office to get rich. The other tribal narrative is...well, that the Bidens aren't particularly corrupt. Setting aside which direction the facts are consistently breaking, one tribal narrative has to be false in order for the other to be true. In your model, since you clearly believe Red Tribers are correct, are entrenched Red Tribalists denying reality?

edit: well, OP changed substantially after I hit post.

Dropping a literal biblical plague of retards on your political opponents should be classified as a war crime. We need a new Hague.

I've been saying the same thing for years, but Anime Con keeps happening and nobody puts the organizers on trial for crimes against humanity.

Watch your tone or I'll ban you too.

The joke is that I'm not a mod. He is.

It's interesting that the cuts are occurring to the "next generation" of incoming talent, although it somewhat makes sense - Penn PhDs are funded, with very nice stipends.

Penn PhDs make about 30k a year, or 24k after taxes. Entry level at costco, maybe 1.5-2x minimum wage. Entry-level for someone with a bachelor's of science in a biotech company in Boston or SF is like 55-70k. 'Generous' is not a word I would use considering that they aren't sitting in class all day, they're spending 8-12 hours a day grinding out experiments so Penn professors (and grad students, to be fair) can publish papers. It's closer to an apprenticeship than what you typically think of as a college degree.

The whole point of the Ivy, I mean, Ivory Tower is to strengthen their own prestige and little robots, so rescinding feels weird. There's also the ability to dip into the endowment, but I know that gets complicated fast.

May be true at Penn, but isn't true at all of the state schools and smaller liberal arts college where the majority of people go. There's also complications around turf wars - the faculty of medicine can't just dip into the endowment when they feel like it. It's also easier to just turn on the taps in a few years if the administration changes than try to keep a constant enrollment.

Are any international future students getting the boot?

Contrary to popular belief, international students at the PhD level are either self-funded or intensely meritocratic. Most of the NIH training grants and PhD student grants that fund a lot of students are unavailable to international students, so most schools cap it at 0-1 international students per year as their costs are harder to cover. Excepting cases like students from Singapore (and China in the past) coming over with a full ride from their government.

Or will academia, particularly STEM, turn to embrace private funding more thoroughly? Private influence in STEM academic research could increase innovation and development, and solve the "funding crisis" presented from the withdrawal of government funds.

If you think private funding is going to increase innovation and development in STEM research, I've got a cancer drug that's going to increase your median lifespan by four months to sell you for 10,000$ a month. This drug was viewed as such a success (see figure 2) that it kicked off an enormous gold rush for radiopharm sweeping the entire biotech industry. None of those drugs are likely to be anything more than incremental improvements.

Philanthropic funding is different, but also harder to solicit. People with funding from HHMI, CZI, Gates foundation, Broad institute, etc. all do great work. Biotech research is just inherently too risky and capital-intensive to be worth it to VCs unless you're coming to them with something that's been pretty well worked out in academic labs already or the modality is already established to work on the market and you're just churning out a new drug for a different target.

There's plenty of reform in the life sciences that could be worthwhile. I agree that it doesn't make a whole lot of sense to let Harvard skim a bunch of money for overhead costs, but as I mentioned, many of the scientists out there are working at places with much smaller/no endowments who need the overhead. Or if they had said we're capping overhead costs at X% and compensating by increasing the size of the grants by the same amount, then great. There's a real possibility that Tsinghua and Peking university are the global STEM centers for the next generation. Ten years ago Chinese universities were paper mills shilling unoriginal research in garbage journals, today I'd guess about 1/3rd-1/2 of Cell/Nature/Science papers are from entirely Chinese labs situated on the mainland. A popular new business model in the USA is just licensing drugs that were developed in China; it's hard to see this as anything other than outsourcing domestic talent and expertise the same way we did in so many other industries.

Cutting NIH funding isn't going to bring back manufacturing or balance the budget. It's just going to cripple the next generation of scientists and hand China a win.

Here's to hoping that the next four years do indeed make America great again, again. And we manage to dredge some unity and goodwill out of our desiccated corpse.

For all that we complain, I always ask people: if not the United States, where would you go? And where would you invest? Whatever my family and friends say, they're still investing in American securities. They're mostly still working in the USA. The opportunity here in most fields is unrivaled.

And to paraphrase Curtis Yarvin, I'll bet you 50$ that if you look around your neighborhood, you'll notice 0 changes over the next 4 years attributable to Donald Trump.

Except you haven’t shown me any of these things.

Do you want papers?

I can't and am not trying to tell you that everyone on SickTok is sick. All I'm saying is that EDS is almost certainly a real disease, and not even as ambiguous a diagnosis as some other things that are less controversial.

They only way for them to make more money is to let the cost of everything skyrocket, raise premiums sky high, and then keep 20% of a much larger pot. Which is more or less what has happened the last 15 years since the ACA was passed.

Do you have any data to support that argument? I'm not an expert, but 5 minutes on google makes it look like premiums have been increasing in a straight line since at least the late 90s.

See figure 1.12 and also this reference.

I'll note that the euthanized woman was described as having Ehlers Danlos. Anyone that has casually explored "SickTok" in the past few years will have surely heard of this condition. While I'm sure it's a real disease in some cases, there is undeniably a trend among young women sharing this concept with each other. I actually first encountered this disease when exploring the twitter of a porn model (so sue me) at least a dozen or more years ago. It struck me at the time as an obviously invented attention-seeking condition that allowed her to post hospital selfies every few weeks and be continually weak and bedridden with no obvious externally visible symptoms.

Ehlers-Danlos syndrome is absolutely real, and monogenic in many cases which provides a clear, objective diagnosis. Then there is a bucket of patients with hypermobile joints, issues with their digestive tract and random pain/other things. That being said, seeing someone flex their pinky backwards past 90 degrees, or their thumb way down to their wrist is profoundly disconcerting and also somewhat objective.

The daily podcast yesterday laid out what they expected would have happened. Senate democrats would have asked Gaetz if he had ever paid women for sex (illegal in Florida and most of the US), whereupon he could have:

  1. Deny ever having done it. The leaked documents combined with the alleged testimony of the women already show that the vast majority of people would see that as perjury.
  2. Admit it, in which case you have a candidate for AG admitting to committing a crime just prior to being sworn in.
  3. Plead the fifth, which would also be remarkable and apparently a bridge too far even for Trump.

Perhaps I'm being overly cynical, but I'm surprised democrats wouldn't hold onto this until Gaetz had been confirmed so they could use it as a cudgel against the Trump administration. Maybe they genuinely think he'll wreck the DoJ in a way that his substitute may not.

I expect you'll dismiss what I say as just another smug American chauvinist...but watching you express with great confidence that the geniuses at the US state department were about to crush the Chinese upstarts a few years ago, to joining the ranks of the resident Chinamaxxers should be enough to give anyone whiplash. If anything, it should make readers update their priors about trusting anyone with grand geopolitical narratives.

The US State department isn't staffed by geniuses who can shape the world to their liking. Nor is the CCP. And even if you took US IMO team and forced them to study geopolitics rather than theoretical physicists finance, their ability to influence the world would be minimal. The NWO-deep state-Masonic brotherhood conspiracy theorists believe manipulate world events to their benefit doesn't exist, simply because the world is too hideously complex a system for someone of any intellect or means to meaningfully manipulate. I don't seriously believe that anyone can predict what will happen or who the paper tiger is.

Is China an unstoppable manufacturing behemoth about to steamroll the US navy on their way to Taiwan, or an aging and shrinking nation who imploded their property sector with loads of debt? Is America the global hegemon with the best military, largest concentration of talent and strongest economy in the world, or a sclerotic, internally-divided shitshow? Probably...all of the above? Who can say whether China's population bomb represents a hard cap to their ascension, or whether they can dominate every STEM and manufacturing field to a degree that dwarfs the rest of the world before they lose their dynamism? Or whether China does a Pearl Harbor next October and Americans of all stripes rally around the flag, erasing the problem of partisanship?

The uncertainty is part of the fun, I suppose. But I'm fairly confident that nobody can make meaningful predictions about what will happen consistently. And I'm certain that whatever happens, some asshole on TheMotte will write a novella about how fucking stupid Trump/Xi Jinping were for doing X when any retard could see that Y was the obvious course of action. Hindsight bias is a helluva drug.

It seems Americans simply cannot conceive of having a serious or superior enemy...They feel like Main Characters of history, who are destined to win for narrative reasons and therefore can afford arbitrary foolishness in the midgame – at it will amount to is a few extra lines in the moral takeaway in the epilogue. Karl Rove's famous quote is quite apt.

All of these criticisms can be leveled at the Chinese as well - you've never heard them rant about 5,000 years of civilization? The century of humiliation making them temporarily embarrassed hegemons, from which they will inevitably recover? And you think that a world where China is hegemon won't see shit like Trump's exploitative trade war on the regular? Look at how they act in the SCS, or fish the hell out of South American countries EEZ. Look at where the Thomas and Sabina shoals are on a map and tell me what business they have ramming Filipino ships. Look at the wolf warrior diplomacy bullshit they pulled before realizing how ugly pulling back the veil made them look. Now scale that up to hegemon-level.

Not to mention I'm fairly confident I've seen you mock Americans hyping the 'Chinese threat' and making them out to be more competent than they actually are as a motivation for more defense spending.

Were you living in reality, you'd feel more incensed at nonsensical, low-IQ-racist boomer copes that keep undermining your side's negotiating position.

I've burned plenty of incense. It hasn't gotten me anywhere, and I've seen how miserable the people are who walk far enough down that path. Boomers gonna boom boom boom my friend.

Because 0.00001% of their endowment amounts to 5,000$.

If you see someone on tiktok who never shows you concrete evidence of any of the symptoms above and claims to have EDS, be skeptical and say social contagion.

If I can show you that loss-of-function mutations in collagen or collagen-related genes lead to a syndrome characterized by defects in collagen (i.e. joint hypermobility, esophageal issues, frequent dislocations, weaker blood vessels and organ tearing) with a very high penetrance and that tracks in families, if I can compare mutant and wild-type forms of those proteins in in vitro functional assays and show a difference, if I can either knock those genes out or induce the same mutations in various animal models and show the same syndrome and you're still skeptical of the existence of EDS I'd say you're an [expletive redacted].

If I can't show you a genetic mutation for a subset of patients that still have many of the symptoms above, well, sure, some people may be lying. But...you understand this is true of many diseases, right? Like, do you not believe in lupus? Clinical depression? Rheumatoid arthritis? Many (possibly the majority, or all) diseases have extreme monogenic forms and milder polygenic (we assume) forms. Similar to Alzheimer's patients with mutations in PSEN, APP, etc. who get an aggressive, familial form of the disease in their 30s versus most Alzheimer's patients who show up ~60-75.