JhanicManifold
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User ID: 135
JhanicManifold
11mo ago
The recommended dosing has you slowly ramp up the dose over like 2 months until you get to the truly effective amounts. I suspect that you would get very large gastro-intestinal side-effects if you just went from 0 to the effective dose. Semaglutide also has a very long half-life of a week, so if you're injecting 1.0mg/week steadily, to get the same blood concentration with a single injection you'd need 2.0mg. I think it would be a fairly bad idea, there's a good chance that the diarrhea and vomiting you'd get would wipe out any mental benefits from the lack of hunger.
JhanicManifold
11mo ago
I've had the same "I can do it myself" mentality for years, and I did have intermittent successes before starting semaglutide. I can stick to a diet perfectly for roughly a month at a time and lose 10 lbs, the problem always comes when life gets stressful and suddenly my mental energy assigned to the diet starts to decline, if It's crunch time and I have an important presentation tomorrow, I can't also be really fucking hungry because I'm in a 1000cal/day deficit, I'll just throw the diet out the window for the stressful time period.
Semaglutide takes care of all that, and I don't need to have zero stress in order for me to stick to the diet, that now happens more or less effortlessly. I still need to have enough mental space to prep my diet foods at regular intervals so I don't eat out instead of eating my home-cooked stuff, but that's a much lower bar than tolerating hunger.
JhanicManifold
11mo ago
I mean, if you want large costs for the same benefits, there are plenty of effective weight loss drugs with a shit ton of unhealthy side effects, DNP and trenbolone will make you lose weight, they just might also kill you lol, their side effects are not subtle at all. Free lunches are rare in the world, but there's certainly lunches that are more expensive than others.
JhanicManifold
11mo ago
Do you think the COVID vaccine will literally take 5 years off most people's lives? There have been semaglutide studies going up to like 24 months without adverse effects for weight loss, and weaker stuff in the same GLP-1 class like liraglutide has been used for years. We might find negative effects later on, but In general, stuff that doesn't have massive negative effects in the medium term won't suddenly get massive negative effects in the long term.
And regardless of this, if any negative effects happen in 30 years, I fully expect future AI medicine to make them completely trivial.
Semaglutide works really, really fucking well.
JhanicManifold
11mo ago
Eh, looks fine to me, I don't see the exterior of my house that often, and especially not from a drone's point of view, if building it that way made the interior more suited to my needs by a small margin, the tradeoff would've been worth it.
JhanicManifold
11mo ago
Nah his current risk model is more like "AI discovers fundamental new principles of science, and exploits phenomena we don't know about to kill everyone", that's what the "send an air-conditioner blueprint to the past" example he keeps talking about is meant to illustrate. The nanotech/biotech distinction doesn't seem especially sharp or important to me, it's just different ways of getting at fine-grained control of very small things.
And in the typical FOOM scenario (which is admittedly probably unlikely), you might get an AI that can do like 100 years of intellectual work of an entire civilization made of Geniuses every single second, at which point it seems like it could solve nanotech trivially.
JhanicManifold
11mo ago
Here's gpt-4's answer, which isn't bad all things considered, not especially out-of-the-box necessarily, but it seems fairly competent to me. Though of course the implementation details are where the real problem lies.
JhanicManifold
11mo ago
Ross comes close to understanding what the real risks are in his top-right "unforeseen consequences" node, but then he somehow links that with free will and consciousness, which is just a moronic misunderstanding of the AI-risk position. Unfortunately he doesn't seem to have found a convincing argument against AI doom.
JhanicManifold
11mo ago
aah I don't know, I've had a few obscure papers from 2013 and 2014 come up that basically implemented aspects of a few of my projects. And at one point it pointed out that what I thought was a shiny new idea was in fact called "Optimal Importance Sampling", and linked me a paper from 1991 that explained it. So it's still pretty useful unless you're doing stuff that is basically the next obvious thing to try conditional on current research, and as such are worried about people scooping you.
JhanicManifold
11mo ago
I'm barely half into the first chapter, but man, I already fucking love this! I can sense that this story is going to scratch an ungodly number of literary itches for me...
JhanicManifold
11mo ago
I haven't had much luck at making gpt-4 come up with genuinely novel ideas for the fields I'm interesting in (Machine Learning, Deep Learning, Reinforcement Learning), the most it can do is serve as a sort of litterature review, where I describe an idea I have, ask it if it exists, and if it does to link me the papers. Sometimes it hallucinates papers that don't exist in this way because it thinks that generating positive answers is more useful than negative ones, but I've gotten real value out of this procedure a few times, where it spit out fairly obscure results that I would've never found on my own.
And don't forget the brothels... they're called "studios" there, and there was a truly surprising number of them when I went last summer.
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