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vorpa-glavo


				

				

				
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vorpa-glavo


				
				
				

				
2 followers   follows 0 users   joined 2022 September 05 18:36:07 UTC

					

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User ID: 674

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Well, the final report of the Cass Review just dropped. It's getting coverage in mainstream publications like the BBC. Surprising no one who paid attention to the interim report, it concludes that there is insufficient evidence in the realm of trans healthcare for children:

Cass told BBC Radio 4's Today programme that clinicians had been worried about having "no guidance, no evidence, no training".

She said "we don't have good evidence" that puberty blockers are safe to use to "arrest puberty", adding that what started out as a clinical trial had been expanded to a wider group of young people before the results of that trial were available.

"It is unusual for us to give a potentially life-changing treatment to young people and not know what happens to them in adulthood, and that's been a particular problem that we haven't had the follow-up into adulthood to know what the results of this are," she said.

Critics are already jumping on the fact that the report used the GRADE approach to categorize evidence, which only allows randomized control studies to be classified as "high quality of evidence" and which can drop non-blinded studies one level in assessed quality, thus preventing many non-blinded studies from qualifying as high quality evidence. (Bold is edit added later. See ArjinFerman's response below, and my response - original GRADE standards can be found here.) The critics point out that double-blinded randomized control studies just aren't possible in some areas of medicine. For a simple example, if the intervention is something like "cosmetic breast augmentation", then there's logically no sensible control group - since there's no placebo that can make people believe they got bigger breasts when they didn't. (It's worth pointing out that this criticism of GRADE isn't unique to trans activists. The Wikipedia page for GRADE mentions it is criticized in general when it comes to slowly progressing diseases like atherosclerosis, where observational studies are easier to perform than RCTs.)

As a result of the GRADE approach, we read things like this in the report:

Understanding intended benefits and risks of puberty blockers

[...]

There was one high quality study, 25 moderate quality studies and 24 low quality studies. The low quality studies were excluded from the synthesis of results.

My own opinion is that I can partially agree with Cass that I want to see higher quality studies around trans healthcare for children in general, but I think that her methodology (using GRADE) is of the sort that will always say we "don't have enough high quality studies", and so her arguments don't have legs to stand on. A problem I see a lot in studies is using some "industry standard" for investigating a topic, and coming to a result of some kind, but failing to justify why the "industry standard" was the best thing to use here. In a better version of the Cass Review, I would have liked to see a few paragraphs justifying the use of GRADE, and explaining why they used this standard and not some other standard.

I mean, isn't that a thing good scientific reports in general do at all steps of the process? Think of what a critic would claim about your model and methodology, and then explain why your model or methodology is the best one to use in this particular instance. Show that your findings are robust even if you used some slightly different model or methodology, and explain what conditions are necessary for your model or methodology to fail. A quick search through the Cass Review shows that it doesn't seem to have done this. It just used GRADE, didn't really justify the decision, and didn't discuss alternatives or why its arguments are robust under alternative assumptions about the data.

It's a bit circular to arbitrarily use a standard that will say, "there are basically no high quality studies in this medical field" no matter what, and then to conclude in your recommendations to the government, "We need more high quality studies before we do anything more in this medical field!"

Utilitarianism is a stance for reaching moral conclusions, not conclusions of cause and effect. I do not believe economists or political scientists make are in much the business of making assertions of this sort in their academic work -- though you can prove me wrong by citing cases where they do.

I think there's arguably a "descriptive" version of utilitarianism, and a "prescriptive" one.

For an analogy, look at medicine. Medicine as a field of investigation concerns itself with health, and to complete that investigation it tries to find causal relationships between various activities and bodily states of health. There's a descriptive and a prescriptive component to medicine. We pour money into medicine because, broadly speaking, the aggregate demands of humans for health are enough to fund the investigations, but many of the descriptive discoveries could be used to make people healthy or unhealthy.

In the same way, economics as a field of the social sciences is "merely" the descriptive study of how economies work, but the reason we study economies is because we want stable, functioning economies that do a good job of allocating resources and have positive effects on well-being.

As I see it, the "descriptive" part of utilitarianism is the aggregate conclusions of the "descriptive" parts of other fields like medicine, economics, sociology, and psychology, that allow us to answer questions like "If we take action X, what effect will that have on QALY's/preference fulfillment/etc." Those questions are in theory "value neutral" questions, but the reason we are asking the question, and the reason we care about the answer is because enough people think that it is worthwhile field of inquiry. That's the implicit "prescriptive" part - it is derived from the fact that we ask the questions to make a larger policy decision.

I prefer Diogenes the Cynic to C.S. Lewis on this count:

[While masturbating] in public, he wished "it were as easy to banish hunger by rubbing the belly."

While Diogenes is a little intense as an example, I think it's much healthier to think of the sex drive as something natural which needs attention from time to time, rather than making it the central focus of your life, or something shameful. I prefer moderate indulgence to sanctimony.

If you ask me how many billion people I would rather die than my cat, my emotional response is I’m okay losing the three billion+ people in Africa and China and India and such. I don’t know those people. My cat loves me.

Logically though, there’s gotta be a better way to strike a balance between partiality and self-interest, alongside recognizing it’s pretty hard to justify a moral system that values my cat so much. If you recognize that other moral agents exist and that you should seek fair compromises as much as possible, then that seems better than any alternative I’m aware of.

Yeah, as someone who has long been roughly aligned with utilitarianism as an ethical philosophy, I've wondered if it's not better to think of it as one answer to what can happen when a lot of people with policy-making power come together, and want to justify their policy goals in a way that most people would consider "fair."

Basically, if a politician wants to build a road, and they're going to have to tear down your house to do it, it's easier to swallow if they justify their decision by saying they took everyone in the country's well-being into account, and they think the new road is going to do more good than your house in its current location is doing. (It is also easier to swallow if they try to be fair to you by giving you enough money to relocate, so you can reap the benefits of the new road as well.)

I've long wondered if "discounted utilitarianism" or "reflective equilibrium hedonism" would be a better philosophy for individuals to adopt instead. Basically, acknowledging that you don't value the life of 1 foreigner the same as 1 person from the same city, and you don't value that person as much as you do a family member or friend. So you just discount each circle of concern by the amount you don't care about them. You might say, "Well a person from China might make my phone, and that has some value to me, so I value their life at 0.001 times that of one my friends." And then you can do the utilitarian calculus with those decisions in mind. Let the 1-to-1 values be in the hands of politicians and diplomats who have to work out fair policies and justify them to their constituents.

Addressing the other parts of your post:

That demand seems arbitrary to me, and "that's what we use for everything" is a perfectly fine justification.

I agree it's "fine" from a CYOA point of view, as in, no one will be able to blame you for using a standard tool used across the industry. But from the perspective of trying to perform a Bayesian update based on the final report, I'm not sure I agree.

A lot of the scientific method in general is a heuristic crystallization of Bayesian approaches, and so I have no doubt that a lot of what is present in GRADE is justifiable across a wide swath of evidence, and comes to largely the same answer as a Bayesian approach would. But I think that if GRADE systematically downgrades some kinds of evidence from being "high quality", which in a proper Bayesian approach wouldn't require any serious adjustment, that can lead to certain evidence being ignored or de-emphasized compared to where it should.

My opinion is that trans activists and researchers wildly oversold the scientific basis for the interventions they were promoting, and sometimes they were outright lying ("puberty blockers are reversible"). They could have just not done that, and tried to gradually accumulate stronger evidence. But the way things are, gender medicine should have never seen such widespread adoption, and people who allowed it should probably be punished.

I think absent any other evidence, just the existence of the Replication Crisis is enough to call a lot of medicine into doubt, and I see no reason why this wouldn't apply to trans healthcare. That the evidence is weaker than often claimed, is almost certainly true. (I'm not sure that that isn't the case for a wide variety of healthcare fields as well though - is trans healthcare uniquely bad, or is it just as bad as medicine as a whole, and do we need to adopt a whole swath of reforms to deal with things like p-hacking, the file drawer effect, small sample sizes, etc.)

I agree with Cass' conclusion, even if I question her methodologies, because I want to see higher quality medical evidence around trans issues, and especially trans kids. I want the medical research to be beyond reproach, whatever conclusions it comes to.

The basic problem with medicine, across the board, is that we're routinely doing barbaric things to be people, and the only justification we can have is that the evidence shows it will have a better outcome for the patient. Chemotherapy involves poisoning a patient with the hope that the poison will kill the cancer faster than it kills the patient. Amputating a limb might be a tough decision sometimes, but it is most justified if a patient would likely die if you didn't do it.

I want the evidence we use in all instances, especially trans healthcare to be airtight so that no one can say we're poisoning people or removing functional limbs or organs for no reason. It'll still be "barbaric", but if it can be justified as much as chemotherapy, then I think trans healthcare will be in a good place.

And the critics are wrong. If you give a treatment to one group, and not give it to another to another, that's still an RCT. Or you can offer an alternative treatment to the control group. It's a plus when you can blind a patient to what they're getting, but it's not a strict necessity. In this case it's probably just as important to blind the researchers when they're assessing results as to blind the patients themselves.

You're right of course. I think the concerns are more nuanced in some areas of medicine.

I doubt it applies to trans medicine, but I have heard of cases where medicine has such obvious positive effects for the sample group early on, that it then becomes unconscionable to not provide it to the control group (mostly in cases involving terminal diseases with quick turn arounds.) This would be one instance where a study initially meant to be a RCT trial for a terminal disease, might turn into an observational study instead.

And I was clearly thinking of double-blinded RCTs being nearly impossible in some cases, which I believe is true in some areas of medicine, but I can admit that GRADE only requires RCTs period for evidence to be considered high quality. That said, reading through the actual GRADE hand book it does seem like Lack of Blinding is considered a risk for study bias, which can drop a piece of evidence one level:

Example 3: High Risk of Bias due to lack of blinding (Downgraded by One Level)

RCTs of the effects of Intervention A on acute spinal injury measured both all-cause mortality and, based on a detailed physical examination, motor function. The outcome assessors were not blinded for any outcomes. Blinding of outcome assessors is less important for the assessment of all-cause mortality, but crucial for motor function. The quality of the evidence for the mortality outcome may not be downgraded. However, the quality may be downgraded for the motor function outcome.

I'm going to edit my original post to reflect this information, but I'll make clear what I'm adding. Basically, it appears to be the case that non-double-blinded RCTs cannot easily be high quality evidence according to GRADE.

Where did you get the idea that the decision was arbitrary?

I tried to search through the report, and they just used GRADE without really explaining why. I suppose "arbitrary" isn't quite the right word, but "unjustified within the report" is probably defensible.

As I dive deeper into Ayn Rand’s minarchism, I see how little the government has the moral right to be doing in our lives.

I've read widely in the libertarian, minarchist and anarcho-capitalist traditions, and while I think they are often good at identifying certain problems of government, and I'm convinced by the arguments of Huemer's The Problem of Political Authority and Ellickson's Order without Law that these forms of government could potentially work in the real world, I still find myself more attracted to social democracy as a set of principles for organizing society, especially since it's actually been tried in the real world and seems to work reasonably well.

Don't get me wrong, I'm very sympathetic to the view of government that it is just the largest and most successful gang of thugs in an area, and that there is actually little moral grounding for the idea of political authority. But I'm a pragmatist and a consequentialist, and I'm more willing to shrug and say, "if the big bullies take care of the little bullies and make people more free, that's better than the alternative." I tend to agree with Noah Smith's argument in The Liberty of Local Bullies that there are many "intermediate" groups between the government and the individual that often have just as much power to reduce your liberty as the government does.

Imagine a devout Jehovah's Witness in high school refusing to stand for the Pledge of Allegiance because oaths are against their faith, and constantly being punished by their overzealous home room teacher for it. The only way to resolve the issue in a way that preserves the liberty of the Jehovah's Witness to not say the Pledge is to go over the teacher's head, via school administrators. But what if the school administrators support the teacher over the student? The only way to force the teacher to respect the student's religious freedom is to go a level higher to the government, and hope that they will force fines or other coercive measures in order to protect the student's rights.

I think for freedom to be meaningfully maximized you need a centralized government with enough state capacity to force the local bullies to respect freedom. Obviously, it would be foolish to claim that centralized governments with high state capacity always results in increased liberty, but most of the countries I can think of that are good places to live in are some form of liberal representative democracy with free markets and a government with enough state capacity to secure people's rights, and create money transfers and social safety nets (even the United States.)

It's not like Jeremy Bentham was pulling ideas out of thin air at random, he was trying to formalize something that was already informally present in the zeitgeist.

While there might be some truth to that, Jeremy Bentham and John Stuart Mill both came to conclusions that were very unpopular in their day. Jeremy Bentham's idea of decriminalizing gay sex was way ahead of its time, but a very natural consequence of utilitarian reasoning. And John Stuart Mill's arguments for the political equality of women and men was a natural enough idea coming from utilitarianism's universality, but had not yet found widespread acceptance in society. (Reading "The Subjection of Women" is an interesting exercise, because the positions John Stuart Mill has to argue against are often things that basically no one today believes. I think it's hard for a modern person to truly put themselves in the mindset of the kind of positions Mill was arguing against.)

I think we swim in fairly utilitarian waters, and much language around things like victimless crimes and harm reduction come originally from Mill and Bentham.

But I think it's unlikely that they truly feel a spontaneous, pre-reflective love for all of humanity.

As someone with consequentialist/utilitarian leanings, I cultivated my utilitarianism as a set of demanding ethical duties that correct the problems of humanity's natural inclinations. I basically think that emotional empathy is "flawed." I don't feel 100 times worse about 1000 strangers dying than I do about 10 strangers dying. And the fact that my emotional empathy is activated more by seeing a video of someone suffering, than reading about that same suffering feels like a flaw of human sociality.

One of the maxims I've tried to live by is to "act as I would if my emotions could accurately reflect differences in scale of suffering to the minute degree required by utilitarianism." It's not perfect by any means - I effectively have to have a set of rules or heuristics that will broadly lead to that result, because I don't have the ability to cognitively process all of the different ways society will go, and I'm still using flawed human hardware and interacting with humans and animals with flawed hardware, but I think it informs my Effective Altruism, and my larger political goals.

But I agree with you, that I don't actually feel a love for all of humanity. I just try to make my actions indistinguishable from the actions of someone who has a spontaneous, pre-reflective love for all of humanity.