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PaperclipPerfector  1mo ago (text post)   1218 thread views

Wellness Wednesday for April 2, 2025

The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:

  • Requests for advice and / or encouragement. On basically any topic and for any scale of problem.

  • Updates to let us know how you are doing. This provides valuable feedback on past advice / encouragement and will hopefully make people feel a little more motivated to follow through. If you want to be reminded to post your update, see the post titled 'update reminders', below.

  • Advice. This can be in response to a request for advice or just something that you think could be generally useful for many people here.

  • Encouragement. Probably best directed at specific users, but if you feel like just encouraging people in general I don't think anyone is going to object. I don't think I really need to say this, but just to be clear; encouragement should have a generally positive tone and not shame people (if people feel that shame might be an effective tool for motivating people, please discuss this so we can form a group consensus on how to use it rather than just trying it).

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Aren't off-label prescriptions ~25% of all prescriptions? And doesn't applying for FDA approval de facto require a positive return to be expected before the patent expires? And NICE and other meta-analyses came to the same conclusion as Cochrane. And CBT-I isn't FDA approved, either.

CBT-I is cheap and found to be effective in a variety of studies

But what proportion of studies finding positive result is sufficient and what control problems are acceptable? If only a borderline majority of studies are positive and better controlled studies are less likely to have positive results, shouldn't we assign a low probability to a treatment being effective, rather than a high probability?

Yes there are a lot of considerations, that was my point.

I'm really not sure where you are going for this.

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