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Notes -
Vaccine-resistant smallpox would not be anywhere near 99% mortality; smallpox is deadly, but not that deadly (even if everyone got it). I mean, we did live with it in the Old World since the Iron Age or so.
Airborne HIV would suck pretty horribly. I imagine there'd be more survivors, though, and it'd take much less time to recover once it died out. You need something like "airborne HIV with anthrax spores" to be worse. I won't say that that's impossible, but GoF and even deliberate weaponisation isn't going to get there since AFAIK there aren't any lifelong-infection viruses without an envelope (enveloped virus = negligible environmental persistence, because envelopes aren't all that stable); you'd need a development project aimed at de novo virus synthesis and to be targetting these properties, AIUI.
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