This is a first-person account from a psychiatry resident (me) enrolling in a clinical trial of psilocybin. Somewhere between a trip report, an overview of the pharmacology of psilocybin, and a review of the clinical evidence suggesting pronounced benefits for depression.
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It’s possible that the THC was the principal culprit. I have witnessed THC inducing acute psychotic episodes on other occasions before. Bit counterintuitive since most people would think of THC as being less “intense” than psilocybin but I suppose the whole thing is under-studied. I’m surprised that the risks of THC haven’t really permeated cultural consciousness.
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