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self_made_human  amaratvaṃ prāpnuhi, athavā yatamāno mṛtyum āpnuhi  6mo ago (open.substack.com)   1590 thread views

A Depressed Shrink Tries Shrooms

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This is a first-person account from a psychiatry resident (me) enrolling in a clinical trial of psilocybin. Somewhere between a trip report, an overview of the pharmacology of psilocybin, and a review of the clinical evidence suggesting pronounced benefits for depression.

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I think the study does a reasonable job at providing ongoing therapeutic support, but I, idiosyncratically, have never found that therapy worked well for me. I did the bare minimum to keep them content, and didn't notice much of a change. The doses caused immediate and lasting changes in mood, before any followup therapy.

I’m interested in how the results between 10 mg and 25 mg will vary in the trial. I suspect that the higher dose benefits would be more noticeable and would last longer.

Hopefully, once the results are out, we'll have a proper understanding of the dose response curve at play here.

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