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This is a first-person account from a psychiatry resident (me) enrolling in a clinical trial of psilocybin. Somewhere between a trip report, an overview of the pharmacology of psilocybin, and a review of the clinical evidence suggesting pronounced benefits for depression.
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Notes -
I care about weirdness because its a sign were missing something. This kind of weirdness is not about violating how we expect things to work, you could substitute most properties for "recreational" and it would still be weird. So I dont think it matters whether the body is intutive. By analogy, the current best proof of the four colour theorem works by proving all graphs countain one of 633 possible configurations, and brute-force checking that each of them is reducible in a certain sense, which they all are. You dont need to know anything about mathematics to see that there might be more going on there.
Thats certainly interesting. Even after years of reading Scott, I still had the impression that after the SSRIs, its maybe MAOIs and then nothing. Its still interesting that its only recreational drugs so far. I think cerebrolysin was supposed to be that, but it doesnt seem like that went anywhere.
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