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naraburns  nihil supernum  1yr ago (text post)   31758 thread views

Culture War Roundup for the week of January 2, 2023

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Although as an aside, this really is something I'd love to find out more about: has there been any testing of dose-response curves? If we could have gotten half the breakthroughs for 5% more side effects with a higher dose, or half the side effects for 0.5% more breakthroughs, but what we did instead was just run with the first educated guess that someone got into trials, just because the FDA doesn't like to see things vary without restarting long expensive trials from scratch, that could belong pretty high on the long list of things the FDA ought to be criticized for.

They did it for the children dose I think. They still came out with more death on the injection side than what covid gives to children, but somehow that was not a concern.

The fact that there is a standard dose is somewhat concerning, or is it not?

According to this article, there is a standard dose.

Now let's ponder what it means that Moderna/Pfizer had to create a dose that would work just as well for the finest 300 lbs American citizen and the diminutive 150 lbs one.

Is the material just as likely to reach the key immune components necessary for whatever immune response is expected by the merchants in a much bigger body?

Would a bigger body necessitate a larger amount of material to reach the same response due to some unknown logistics?

Are the less-boldly-bodied people getting a larger dose than they would actually need? An excessive dose perhaps, that would perhaps concentrate the material into some cells, say the heart or some other critical tissue?

Now let's ponder what it means that Moderna/Pfizer had to create a dose that would work just as well for the finest 300 lbs American citizen and the diminutive 150 lbs one.

Is the material just as likely to reach the key immune components necessary for whatever immune response is expected by the merchants in a much bigger body?

Yes.

You're asking these questions like this is the first vaccine ever proposed. We know the answers from several decades of experience developing vaccines. Dosage of vaccines is tiny and not weight-dependent because the immune system doesn't work that way. Dosage is smaller for children not because they are smaller but because their immune systems are less developed.

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