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Viruses replicate, in a way that the mRNA vaccine...doesn't? And goes into your bloodstream? And the receptor implicated in viral entry in COVID is expressed throughout the body.
Conversely, you get less systemic action (though still some) with the jab, because much of it stays pretty local to the injection site.
Most likely not very much, because:
Viral integrases are particular about what sequences they integrate, and...
A cell that is that actively translating viral reverse transcriptase is a cell that's...dying to the virus (if it wasn't being transcribed+translated and instead is in a provirus state, then there would be no issue), while a cell that is actively translating human reverse transcriptase is probably a cancer (or you're quite old, or it's differentiating, etc), and...
The mRNA vaccine might not even be readable, given that it isn't made with normal RNA nucleosides, and...
Even if it gets integrated it likely wouldn't do very much!
This is all talking about viral RTs; we humans have reverse transcriptase sequences in our genomes as well, from ancient retroviral infections (as you allude to). COVID itself possibly could be reverse transcribed into a small number of cell lines post-infection in a much less controlled manner, producing chimeric human-viral proteins. This would likely affect a small minority of people, and the actual health effects are pretty unclear.
Based on this, I would be much more worried about sequence integration post-infection compared to post-vaccine. At least you can engineer synthetic RNA-like molecules to be less recognisable by LINE1 retrotransposon RTs, and even if it happened, you can control the sequence being inserted.
It wouldn't just spontaneously turn into DNA. Reverse transcription is not a modification of the RNA sequence, it is a synthesis of new DNA strands based on the old one. Good luck doing that without an enzyme turning ATP into energy for that synthesis.
Have fun with that, biology is messy, and proving a negative is....well.
The spike protein could be produced if its sequence integrates into DNA.
What if there is so much RNA floating around that they just act in a more non-specific way?
Maybe. This is all about chemical logistics.
The assumption is that the mRNA is safe from integrating DNA because there is no reverse transcriptase packaged with it
turns out there could be cells containing reverse transcriptase but then the cells are probably dying so them getting spike DNA wouldn't matter
so we're assuming that the event won't happen because the enzyme and the RNA would not be together in the same cell
or that cell would not be producing spike protein for long
So it seems unlikely that we would have spike protein or some other type of foreign protein continuously produced after the injection. But then who knows what actually happens, until this is actually studied?
Did anybody test the same thing for injected people? That's what I'm asking for, before 'fact-checkers' assert that 'it's impossible'. Actually test it, then tell me whether it's possible or not. If one study finds no evidence of such a thing occurring in a large sample, it's better than a couple people hand-waving the issue away.
That seems correct. It seems that reverse transcriptase would be necessary for integration into DNA.
Not even making an attempt at providing evidence while simultaneously claiming something to be impossible is even worse. If it's impossible, at least produce evidence that you could not see it happen when you looked for it.
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