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naraburns  nihil supernum  1yr ago (text post)   5440 thread views

Small-Scale Question Sunday for January 22, 2023

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

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Thanks Cafe, that is a great comment, exactly the kind of informatively rich comments the motte desperately lacks.

I will give you a proper answer tomorrow but when I said that tryptophan cross the BBB, I actually meant about 5 hydroxy tryptophan (5htp), which has good bioavailability, cross the BBB and bypass the rate limiting enzyme conversion of L-tryptophan to 5htp (which itself downstream will again be converted to serotonin in a rate limited manner)

1998:

https://pubmed.ncbi.nlm.nih.gov/9727088/

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