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I am glad that you and others replied with something to this effect. My mom and my aunt are both on Wegovy, and neither of them seem to be losing weight. Mom gets horrible nausea from it a few days after each shot, so she'll sometimes skip injections. I expected a lot more out of them from what I was reading self_made_human claim about them.
Well, "miracle cures" aren't, by and large (except maybe in the early years of antibiotics when it was the Silver Bullet that cured damn near everything, and then eventually we got drug-resistant strains).
For some people, it will work fantastically. Cuts down hunger, makes you feel satiated, weight comes off, general boost to willpower, even claims that it's an addiction cure for smoking, drinking, lack of moral fibre, and so forth. For most people, it'll help. For some people, we'll be there looking at all the "no excuse to be fat now that GLP-1 drugs are there" posts and wanting to drop a flowerpot on poster's head. Definitely it's helping with my blood sugar levels, and since I got prescribed it for Type 2 diabetes that's the main concern. But the main weight loss is from the initial "this will have you running to the bathroom every five minutes until your digestive system adjusts", for me at least. Nausea and diarrhoea mean no eating, and naturally no eating means water weight loss, which shows up on the scales. As for your mother skipping injections, either try and keep on a regular injection schedule even with the nausea until it passes (and that will take a few weeks), or if it doesn't pass, ask to be put on something else.
The major effects are supposed to be "this slows down digestion, that means food passes more slowly, that means you feel fuller for longer and so won't eat as much". It's had a very weird affect on my appetite. Yes, when I sit down to eat a meal, I don't eat as much as I used to before (I will leave food on the plate instead of eating every scrap). But then half an hour to an hour later, I'm hungry again. And I'm constantly grazing. Small bits here and there (a bowl of cereal, two slices of toast, some cheese, some sweets, so forth) but small bits add up.
Mainly I'm maintaining my current weight, so not packing on more pounds is good, but not seeing the magic weight loss yet. Though I'm on Ozempic and not at the maximum 2mg dose yet. Maybe when my doctor moves me up to that, there will be a visible result? Or maybe not. I'm not holding my breath hoping for a miracle.
As ever, the only thing that works is cut out all junk and snacks, cut down on carbs, eat much fewer calories in total, and exercise for muscle toning and retention.
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Ideally, perhaps this enables long-term research to separate out multiple causes of weight gain / aberrant appetite by analysing differences between those who respond to GLP agonists and those who doesn't.
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