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Small-Scale Question Sunday for January 29, 2023

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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Is this like most interesting topics on earth, something where humanity has pathologically, systematically stopped the depth of the discourse at the introductory level, or has this author or any human on earth cared enough to specify a semblance of a roadmap towards the stated hedonistic goal via bioengineering?

Where can I find a e.g. an exhaustive list of pharmacological pathways that promote positive valence qualias and of pharmacological pathways that downregulate or dampen negative-valence qualias?