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Notes -
HIV was discovered in the early 1980s, a few years after AIDS was recognized as a disease. The first drug was AZT 4 years later (6-7 years after the pandemic started), and that was a stroke of luck in that they repurposed an oncology drug that just happened to have activity against HIV. The first protease inhibitor (something designed specifically to target an HIV protein) was mid 90s, or ~15 years later.
Contrast that to COVID-19, where we had a bajillion genome sequences within months of the virus spreading, RNA-Seq datasets from infected patient lungs which led to a number of therapeutic trials (unfortunately didn't pan out, but still good shots on goal). We had paxlovid (a COVID-19 specific protease inhibitor) within a year. We had mRNA vaccines in a similar timeframe, which were more effective than anything we'd seen prior and outperformed anything the Chinese could do - how many other American institutions can say the same? That's about a 10x compression in timelines for identifying, characterizing and developing drugs to an emerging virus.
All of this, pearls before swine. Hundreds of thousands? Millions? of man hours by people like me all so some retard on twitter can go viral (no pun intended) for writing some hysterical slop about how the mRNA vaccines are going to cause mass infertility/blood clots/insta-death (how did all those predictions pan out?). The public has no idea how much effort is expended on things you would never think of - pharmacology, every manufacturing/storage/distribution step, toxicology and safety, in vitro and preclinical models. The public is ignorant of how far we've come, and the oceans of sweat and tears and grinding in the lab that have built this edifice to improve their lives.
Half the country saying the FDA moved too quickly, mRNA vaccines are dangerous, blah blah blah. Other half saying they have the blood of hundreds of thousands on their hands. Half the country saying lockdowns are ineffective (as if China didn't exist), the other half that the government doesn't care about their safety and people are dying. Maybe in addition to the internet, the other thing that's changed is everyone with a twitter account feels entitled to weigh in on every issue.
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