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Notes -
I've never done it myself (and would be terrified to) but it's quite interesting to read these and then connect it to some of the research that's been coming out. Psilocybin AFAIK disrupts functional connectivity in the brain quite aggressively and basically causes different brain networks to become less segregated and bleed together, and it does so most severely in the default mode network, which basically creates your sense of time, space and self. So you get ego death.
It also helps to suspend depressive symptoms by disrupting the connections between networks, specifically the hippocampus and default mode system, which are associated with that. Your thought patterns are quite literally spilling into each other on the fly in a way that can completely disassemble your entire perceptual and affective world temporarily, and it offers the possibility of your mental circuitry settling into a subtly changed baseline for better or for worse. It's basically very imprecise, very ghetto biohacking.
I honestly don't think it's all bad and has some possible transhumanisty applications, but as it currently stands the drug is like a sledgehammer where the effects aren't fully understood or controllable. If not I would be all in to be honest.
I agree with you. That's my understanding of my the mechanics, though note that there's also a general increase in neuroplasticity as well as evidence of some neurogenesis.
In predictive processing terms: psychedelics relax your priors, which helps unstick the stuck ones (like depression).
For what it's worth, I was always fascinated by psychedelics even as a teen, and wanted to try them recreationally. But I avoided them for a decade, because I was too afraid of the risk. Then my depression got really bad, and I felt the clinical trial was a good shout before I resorted to IV ketamine and ECT (very annoying to get in my parts of Scotland). It worked wonders, and gave me more confidence that I could push things.
Uh.. Turns out there's a limit to how far I wanted to push things. I might try LSD again, but never at this dose. I've had my fun. I like my sanity. If you do specifically want a treatment for depression, the evidence for psilocybin is much more robust. You've probably read my blog post, but if you haven't, it's in my posts.
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