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Notes -
Of course. I just read and wondered if some patients had an innate susceptibility to side effects while others never did. Would be interesting if so.
As a lay person, it’s always complicated looking at lists of side effects. Take a side effect of:
Very rare: stroke.
Does that mean that every time you take it, you are rolling a 1:10,000 chance of stroke. Or is it 1e-9 for a young healthy person and 1:10 for a very elderly person who’s already had one stroke? And so on.
The BNF provides a way to convert from intuitive explanations of risk to quantifiable forms. Common is like >10%. Very rare is like 1:10,000. That's not in terms of every time you take the pill, it's what you'd see in a patient who is taking the pill for prolonged periods of time.
And yes, patient demographics do change things. The elderly are particularly annoying, they'll collapse if things aren't dosed just right.
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