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Culture War Roundup for the week of June 22, 2026

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So, I mean, Alzheimer's is a specific condition, it's associated with elevated amyloid-beta levels, and aducanumab reduces amyloid-beta levels. We should rush out and give all the Alzheimer's patients aducanumab, right? No need for testing!

Except, wait, they did the testing and it shows that aducanumab doesn't actually slow cognitive decline, which is the outcome we actually care about. Turns out that having an explanation for how something could work doesn't necessarily mean that that explanation is correct or that it does work.

Incongruous genitalia or secondary sexual characteristics aren't associated with gender dysphoria, they are gender dysphoria. Gender dysphoria is the symptom to be treated, unlike in Alzheimer's, where dementia is the symptom to be treated, and it was thought that targeting amyloid-beta would treat it.

The statistics on transsexuals that transition are awful. It is possible that they're slightly less awful than the statistics for would-be transsexuals that are prevented from transitioning.

It's not realistic to expect trans people to be as happy as cis people on average. Trans women generally don't want to be trans women, they want to be cis women, they want to pass and have functioning reproductive systems, etc. But this is the best we can do with current technology. It is perfectly reasonable for someone to be unhappy about this. Ugly or infertile cis women are often unhappy, too.

I dunno, because TTBOMK nobody's actually done the RCT. Doing the RCT would be really hard due to trans activists sabotaging the control group, sure. That doesn't make not having it done less of a problem.

IIRC the Cass Review suggested an RCT on puberty blockers. Not sure what's going on with that, or what their stance is on proper HRT, or if any of this is relevant to adult patients.

I will note that I had full phantom-limb gender dysphoria and (mostly) grew out of it; it's not obvious to me that the "would benefit from transition" group can actually be distinguished from the "would be harmed by transition" group.

Again, many anecdotal reports of people who tried ignoring their dysphoria and it never went away.

Incongruous genitalia or secondary sexual characteristics aren't associated with gender dysphoria, they are gender dysphoria.

Gender dysphoria is the feeling that they're incongruous, which is not quite the same thing. There are two ways to fix gender dysphoria: make the self-concept fit the physical body, or make the physical body fit the self-concept. Which works better? Well, I dunno. RCTs are the way to find out.

(Note that body dysmorphia doesn't respond well to surgery.)

Trans women generally don't want to be trans women, they want to be cis women, they want to pass and have functioning reproductive systems, etc.

You don't need to tell me that; I arguably was one.

We are doing transitions with transition therapy as it really exists, not Culture Cycle clarketech. If transition therapy as it really exists doesn't help actual life outcomes, then it shouldn't be the standard of care (with obvious knock-on effects regarding public funding for it, regarding medical advice to dysphoria sufferers, regarding letting minors do it, and regarding family-court judgements).

Again, many anecdotal reports of people who tried ignoring their dysphoria and it never went away.

Define "never". Took over a decade for me.

Maybe for some people gender dysphoria goes away, but for many it never does. "John 50" is a meme for a reason. I mean, the claim that it will go away eventually is unfalsifiable, but at some point you can be reasonably confident. Do you think there's some kind of fancy psychotherapy, or maybe medication of some kind, that could free more people of dysphoria, that is being slept on?

You don't need to tell me that; I arguably was one.

Define "never". Took over a decade for me.

I'm going to need you to clarify what exactly your condition was, because "phantom-limb gender dysphoria" doesn't mean anything. In any case, I can provide anecdotes of people "repping" (repressing) for over a decade until they gave in.

We are doing transitions with transition therapy as it really exists, not Culture Cycle clarketech. If transition therapy as it really exists doesn't help actual life outcomes, then it shouldn't be the standard of care (with obvious knock-on effects regarding public funding for it, regarding medical advice to dysphoria sufferers, regarding letting minors do it, and regarding family-court judgements).

It's imperfect now, but it's going to improve as technology advances, and it's only going to improve if we keep doing it. The fact that it's imperfect now and doesn't work for everyone is no reason to give up, otherwise we wouldn't have most of modern medicine.