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Sodium channels do not "feel" pain, they transmit the information and perhaps the qualia of pain. It seems plausible to me that the stimulus provided by the sodium channel specifically impacts the specific qualia of pain (pain feels very different depending on the circumstances, so I can imagine a different method of communication altering the specific unpleasant qualia; off the top of my head, I am not sure if there is research on this), but I don't think the channels are perceiving; you are perceiving.
Some physical computers have voltage-gated electron channels. Is it possible that voltage-gated electron channels can transfer pain signals? Perhaps (I don't have a strong enough grounding in the relevant disciplines to be able to rule it out) but there is no reason to believe that they do so in GPUs: GPUs do not have a nervous system, or the various nociceptors or other sense receptors that human beings have, or anything that is analogous. Basically, GPUs have no way of detecting pain. Nor have GPUs ever been measured responding to painful stimuli in the way that humans have. Do you think GPUs have sensations?
I would argue that it is nonsense to say that an LLM has voltage-gated electron channels. An LLM is a software program that runs on a computer. That computing device can be built with voltage-gated electron channels. But (as far as I know) you could run an LLM on a different Turing-complete computer: an optical computer, for instance, or, in theory, even a Magic: The Gathering computer, or a crab-based computer.
They might, depending on what program they are running. The same way a human body might or might not have sensations depending on whether or not it is alive.
I think you are getting tripped-up by the distinction between software and hardware. This is only a conceptual distinction. Software exists in the physical universe. A GPU running Mistral Small 24B is in a different physical state than a GPU running Counterstrike. One could build a custom electronic machine which has no "software" as we understand it, but which runs and can only run Mistral Small 24B. Would such a machine be more likely to experience sensation than the same functional program running on a GPU in a data center?
Really? Is it your belief that a GPU can become sexually aroused, too, given the right software?
No. They both would not be able to experience sensation at all. There's no mechanism for them to experience sensation. Arguably there's no mechanism for them to experience anything, but we don't need to grapple with the hard problem of consciousness when we can grapple with the trivially easy problem of "literally no capability to have this experience."
If I receive the right instruction, can I levitate? Or does it turn out that it is physically impossible to do things if you don't have the right physical capacity to do those things?
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