To what extent are humans optimized? Compared to the most efficient method of land mobility (that still retains all the same functionality e.g. ability to climb stairs) how efficient are human legs? Compared to the most efficient way to take in their respective types of data, how efficient are human eyes, ears, etc?
Most importantly, compared to the most efficient way to do the types of calculations it does, how efficient are human brains/neurons etc.? Obviously, digital computers are much more efficient at the types of computations they do. With semiconductors as an obvious counterexample, we can be fairly certain that any digital computation human brains do is not even close to the theoretical maximum efficiency it could have. But I've heard some say that human brains might use certain types of analog computation at least in part. Is it possible that the analog parts of human brains are even e.g. 10 percent as efficient as a maximally efficient version of computational substrate designed for a similar purpose?
Obviously, all the answers to this will probably be well within the realm of conjecture. Unless, that is, anyone actually does have some sort of publication going into detail about this type of thing, but I doubt it. I'd still like to see what this community cares to predict about this subject/offer as conjecture.

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Notes -
The left recurrent laryngeal nerve and the vas deferens are classic examples of suboptimal anatomical features. One might imagine there are structures in the brain that are suboptimal in a way that is analogous to the left recurrent laryngeal nerve and the vas deferens. Perhaps there are some we have yet to recognize as such because we don't understand how the brain works.
This is the mechanism for why the body isn't fully optimized: it has to be backwards compatible and build iteratively off of previous DNA. That tech debt is exactly what an artificial engineered brain/body could re-design.
That makes sense, direct editing is going to cause a lot of indirect problems. Similar to immune system or dietary supplements.
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