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Small-Scale Question Sunday for September 3, 2023

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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yes you got it right but as usual, nothing is poison, everything is poison, it is the dose (and frequency) that makes the poison. Also hormesis can be a thing https://en.wikipedia.org/wiki/Hormesis Anyway my speculation is that taking frequent weed before the age of 18 (or maybe up to the twenties) is a scary risk factor to permanent brain damage/altered development

The legalization or de-demonization of thc might accelerate the reversal of the flynn effect https://en.wikipedia.org/wiki/Flynn_effect and accelerate the downfall of society. Or maybe not? Anyway I don't believe that infrequent use at adult age is a big deal, especially when concomittant with e.g. skq1 But the greater point is that we are very lucky to have drugs that have in large parts, observable toxicity.

We could very well live in a world where people take drug X and the toxicity is only revealed by e.g. a sudden death rate of 70%, 30 years later. Many kinds of toxicities are non-observable (except in a lab) or low observable, which are so called, subchronic toxicities. Neuron death, dysregulation, oxidative stress and teratogeny (mutations) are in large parts non-observable. In addition to those, the popular drugs just so happen to have observable toxicities too.

Given that we live in a era of contingent extreme ignorance (no standard database to correlate human's diseases rates with the prescriptions and drugs they take in their lifetimes) It is a fact that some horryfing quality of life reductions are happening silently for many people because of subchronic toxicities. E.g. IIRC chronic coffee use leads to white matter shrinkage (but conversely considerably reduce the rate of neurodegenerative diseases)