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PaperclipPerfector  3mo ago (text post)   2515 thread views

Small-Scale Question Sunday for January 28, 2024

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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Anyone has any experience taking dopamine precursors like L-Tyrosine or Mucuna Pruriens ?

I've tried DL-Phenylalanine alone and didn't get much of an effect at 500mg.

However, when taken before Kanna it did seem to give a small mood + focus boost to the Kanna effects. Kanna itself upregulates VMAT-2, which causes more monoamines (including dopamine) to be released. Kanna also does many other things, so it is hard to exactly say what mechanism caused the subjective effects.

I've also tried Oroxylin A which has a Dopamine Reuptake Inhibitor component. This felt much stronger than the dopamine precursor. I would say it felt somewhat like caffeine, but more noticeable and clean. It also synergized well with Kanna and enhanced the mood + focus effects.

I've had really mixed results with Kanna and I've used it less than 10 times. These combinational anecdotes may just be a coincidence. Sometimes I barely notice the Kanna and then when I take the same dose again the mood and focus boost is much more noticeable.

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