Inflamed_Heart_Liberal
No bio...
User ID: 648
Inflamed_Heart_Liberal
1yr ago
Also - don't forget that development of inactivated vaccines seems to have been halted in its tracks, and Covaxin rejected by the FDA because "we have vaccines already."
Of course, the market would prefer a vaccine that is 100 times safer than mRNA style, but the FDA helped embargo any protein vaccines.
I literally think the FDA blocked conventional vaccines, to make sure no "anti-vaxxer" could score a win by being hesitant until a better vaccine is available - a total cluster for people trying to paint anti-vax as anti science, if they line up to accept a conventional vaccine. Will they now? Probably not.
Inflamed_Heart_Liberal
1yr ago
Fair, and yet here we are, 1/11/2023, and somehow there is disinterest in important Covaxin to increase the vaccination rate. All because they can't say "we have the real ones now."
Have you seen booster update? pitiful. This is the future for mRNA when held in a free and open market next to protein-adjuvanted vaccines.
I am going to do my best to write a post to follow up on last week's mRNA vaccine hypothetical. Last week, the idea of 25% of the population "dying" from the vaccine would have social consequences, and people discussed. I noticed a lot of in-the-weeds back and forth on the vaccines, and luckily, a paper came out today to establish a non-hypothetical.
https://www.sciencedirect.com/science/article/pii/S0264410X22014931
I am having a lot of trouble with this. The pfizer vaccine is associated with an increase in Pulmonary Embolism, which is a blood clot in the lungs. There is severe disinterest in classifying these types of blood clots. I noticed that the scientific establishment went very far to profile "microclots" of the COVID-19 disease, but noticed that clotting incidences during Flu were never really elucidated or investigated. Science is a man made, bumbling golem. Blood clots in the lungs, according to my traditional reading of Physiology, would generally mean you can have blood clotting disorder anywhere you have blood. The Heart, The Brain, and the Lungs just have the worst, smallest pipes for these clots to be detected in.
A note about Covid being a clotty disease - covid blood clots are "amyloids" that cause "long covid" - then what are blood clots that appear during a flu sequalae? These probably have never been investigated or characterized. Covid is more clotty than flu - but are we considering that Covid causes severe sleepiness and lethargy? Do activity levels while infected affect blood clotting patterns during respiratory illness? (admittedly speculation - but have you ever taken a 16 hour plane flight? Look at this article about flu vaccines preventing blood clots, from 2008. They probably do - because all respiratory viruses increase chance of clotting? Well, that's fine, but I bet vaccines aren't supposed to cause clotting.
https://www.sciencedaily.com/releases/2008/11/081109193332.htm
That's all I found. Can you help me with information on clotting from the Flu?
There has been some debate about the "naturalistic fallacy" in arguing that a Covid-19 infection can be characterized as less risky than receiving a Covid-19 vaccination. I keep encountering ostensibly "pro-vax" individuals who are claiming that getting myocarditis from the vaccine is a no brainer, if you are protected against myocarditis from Coronavirus. However, we have no clear mechanisms here, except we saw autopsy results in Germany that prove there can be sudden death after vaccination from the myocarditis related arryhthmia/dysrhythmia. This type of myocarditis is not proving to be common at all with Covid-19 reinfections - I understand that for your first encounter with the virus, your odds profile is completely different. If you already had Covid-19, you have natural immunity. Any further mRNA vaccination is offering a risk without a benefit, now that your immune naivety is broken. If we had more traditional vaccines, perhaps an increased rate of myocarditis or blood clots near the lungs will be decreased, for a similar benefit. Why can't this be broached? Covaxin exists but was rejected by the FDA. The public health monolith seemed to block the chance to be "anti-vax" and win by scoring protection from the virus without being subject to a genetic-based biotechnology
We keep getting dragged down by considering every SARS-2 infection as potentially lethal, when this was really never true. I believe this has created a pervasive "magical model" of viruses where the virus touches one of your cells, and suddenly has a key to every organ in your body (please rebut me). This becomes true when infection reaches a tipping point and moves further than your lungs, but Omicron, combined with the fact that so many people have Natural and Artificial (oh sorry 2019 term - vaccine induced) Immunity, the virus is being kept very mild, and I am highly suspicious of anyone who presents a sequalae based on unique characteristics of SARS-2, when it infects your upper respiratory tract, like the hundreds and thousands of respiratory virus strains that were ostensibly new, and passed through us dozens of times. The true nature of the human ecology and it's interaction with reparatory viruses, since the group Mammalia existed, suddenly seems like a especially dangerous aberration in our times (edit note - typo and word change for group).
It seems "pro-vax" are using some type of time fallacy that hasn't updated. What human is encountering SARS-2 with a naïve immune system in 2023? Why would you take a vaccine that can be compared to the risk getting your first exposure to a new group of coronaviruses in 2023? Then arguments can hit "we didn't know at the time," but this is extremely unsatisfying to people who had these exact suspicions during the vaccine drive, and got sick very early during the "it's just a flu" media push of Feb. 2020 (I was of course, masking in Feb. 2020, sigh).
Am I outing myself as a desperate Mottian by being so befuddled by the seeming lack of interest in a new type of vaccine that can cause heart damage at comparable rates to a novel coronavirus infection. Imagine updated IFRs if you include the recirculating infections going around now.
Please come debate. I noticed more "pro-vax" on this board than usual - I'm ready for you. Let's be clear.
mRNA seems to be the problem. Check the wikipedia article for "solid lipid nanoparticle." Kind of short. A few years of science (okay, I know the line was "decades," which is not impressive compared to centuries of other vaccines). mRNA spreads throughout your body via your blood stream, and this is a technology flaw in the mRNA platform.
J&J, while still newer, did not show any concerning safety signals, and was eventually pulled because it cannot be updated efficiently, and humans become tolerant to the vectors. Or, J&J caused blood clots, killed people, and was pulled/discouraged to direct people to 'safer' mRNA vaccines. I would get more viral vectors, but probably only if I was going somewhere exotic and expected an encounter with a pathogen of special interest to me. J&J platform was also a human virus and will be treated by your immune system as a virus. You, and your mammalian ancestors have naturalistically encountered viruses since the beginning. This is not a fallacy!
Novavax - this one does not rely on stable lipid nanoparticles, but involves a novel nanoparticle that helps arrange spike protein to look more like a "virus." This is important.
Covaxin - the FDA rejected this vaccine because the one's we had were so safe. This was the exact moment I sunk permenantly into my rabbit hole. The FDA and other public health stakeholders created some type of technology embargo against a traditional Covid vaccination methods. The reasons could be many, and I think are becoming deeply cultural, and I'm excited for the conversation we're about to have. Based on centuries old concepts of presenting antigens 'as they are' (insert latin term) rather than conjuring them at the ribosome in the cell, which has been of interest for less than a median human lifetime in the USA.
So in essence, rather than ask you what you think a 54% increase in Pulmonary Embolism incidence after Pfizer vaccination, I am broaching a large anti-mRNA topic, and throwing down. I have placed plenty claims that I expect to be rebutted. If I have seemed at all to sneer or to be uncharitable, I apologize, and would be happy to reword. I wanted to put forward a spirited defense of "anti-mRNA vaxxery", not denigrate anyone on the other side.
I work at a very left wing college - you get inundated with messages supporting exclusively democratic positions. I agree with some, disagree with others, but overall abhor the general tone from my employer, as anyone should.
I'm wondering what the message will be if AA is overturned. They will need to comment AND change practices, which is very different from low-hanging fruit of virtue signaling (aside - I have to refrain from using the term "low-hanging fruit" at this institution).
I think their justification for race-based admission and discrimination against certain groups will be heavily weighted with critical theory - the "disadvantaging whites & Asians is equitable" approach.
At the end of the day, potential ending of AA opens a huge breach in the DEI. Will they circumvent it? Will there be 'sanctuary colleges' where admissions is allowed to be race-based?
My guess is yes, this will heat the culture war. We will be shown unequal outcome statistics, and hear discussion about the 'racism' of this Supreme Court decision, and resulting 'inequity' that comes from the boost in technical 'equality'. I do not believe I am being uncharitable in this description.
Inflamed_Heart_Liberal
1yr ago
This is a strong candidate for a contributing factor to deaths. For example, I'd argue that loss of job due to a vaccine mandate will carry worse outcomes than actually receiving a vaccine, or getting Covid unvaccinated. So in a way, our own public health response could be responsible for causing harm to people
Inflamed_Heart_Liberal
1yr ago
Among the 35 cases of the University of Heidelberg, autopsies revealed other causes of death (due to pre-existing illnesses) in 10 patients (Supplementary Table 1). Hence, these were excluded from further analysis. Cardiac autopsy findings consistent with (epi-)myocarditis were found in five cases of the remaining 25 bodies found unexpectedly dead at home within 20 days following SARS-CoV-2 vaccination.
5/25
Well, this is not the statistical smoking gun I want per say.
So of 35 sudden deaths, 10 were other causes. And then of 25 sudden deaths, 5 were found to have thee abnormality. They were looking for sudden deaths from myocarditis and they found it.
Who knows. We basically agree in a bunch of domains, I just think it's still not possible to say this is a disproportionally unimportant issue.
Inflamed_Heart_Liberal
1yr ago
Fair, I'm not going to rip off my wallpaper over elderly and at risk people receiving bivalent vaccines - precisely because I have a calculation of their quality life years remaining, that is very different from younger healthy people.
The exact people who benefit from a covid vaccine have less quality life years to live than those who do not.
The vaccine has a novel, not totally understood method of mRNA translation, and then goes through another not completely understood process of protein folding, and then enters the immune system (not completely understood). The pharmacokinetics of the nano lipid particle are not characterized or understood. And there is a concerning signal of a blood clot appearing in patient's brains.
I am not scare mongering, I am being highly critical, since I'm not the one defending the novel RNA transfection vaccines.
When they run trials for new vaccines, they will compare them to the harms that the RNA transfection vaccines caused, and the new vaccines are going to look amazing. My guess is they will use protein-adjuvanted methods.
Inflamed_Heart_Liberal
1yr ago
Why? This seems to me like you picked "an order of magnitude safer than what it allegedly is" and if the alleged rate of danger were different, you would have picked a different goal.
https://www.nature.com/articles/s41467-022-35653-z
Here's one estimate. I would never base policy on one study, usually that's something the CDC would do.
I find these numbers to be particularly confusing in light of how dangerous COVID itself is. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02867-1/fulltext#seccestitle140 says that at age 65, the IFR for COVID is about 1.7%
This is data from a year ago. We are talking about how the bivalent booster is associated with ischemic strokes, especially held against the risk of omicron.
And according to https://www.cdc.gov/stroke/facts.htm, the baseline rate of ischemic stroke in the US is slightly over 2 per 1,000 people, again much higher than the alleged risk of the vaccine.
Let's stick to relative risk? This is not useful.
Driving is dangerous.
Agreed. But we have to go places, like schools, small business, and our places of worship. So no one proposes stopping driving. I'm proposing stopping the EUA novel biotechnology vaccination campaign.
Inflamed_Heart_Liberal
1yr ago
CDC has released a report today finding preliminary association between the Pfizer vaccine and stroke for those over 65 years of age.
Another drop in the bucket - or is the bucket spilling out the top now?
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/bivalent-boosters.html
Following the availability and use of the updated (bivalent) COVID-19 vaccines, CDC’s Vaccine Safety Datalink (VSD), a near real-time surveillance system, met the statistical criteria to prompt additional investigation into whether there was a safety concern for ischemic stroke in people ages 65 and older who received the Pfizer-BioNTech COVID-19 Vaccine, Bivalent.
Pfizer is associated significantly with strokes - CDC is keeping us in the dark about the exact data.
This preliminary signal has not been identified with the Moderna COVID-19 Vaccine, Bivalent. There also may be other confounding factors contributing to the signal identified in the VSD that merit further investigation. Furthermore, it is important to note that, to date, no other safety systems have shown a similar signal and multiple subsequent analyses have not validated this signal:
They then list multiple studies that did not replicate this finding for the BIVALENT vaccine - well of course, this vaccine was testing on mice, and then deployed without long term testing. Do they have monovalent data they are not mentioning?
EDIT: Is it possible monovalent risk benefit analysis is simply using a different pathogen, and now with the advent of Omicron, this is a medical update saying this level of strokes is no longer worth the benefit vs the current pathogen? Food for thought.
No change in vaccination practice is recommended.
This contradicts what Paul Offit's opinion is, which was posted in the NEJM. Paul Offit believes we should not give bivalent boosters to young healthy patients.
https://www.nejm.org/doi/full/10.1056/NEJMp2215780
It would be much more shocking to announce a chance to the vaccine campaign, than to keep the current inertia the same. I think we are seeing a communication strategy developing to deliver the population into accepting yearly mRNA vaccines - instead, they will be directed to other worthwhile candidates for vaccination - IF pharma companies can even deliver those.
In my eyes: mRNA vaccines are dangerous, so you need to determine how dangerous the pathogen presenting is. I see a great use case for mRNA developing for Airborne Ebola Zaire strains (90% mortality) or other disease of similar magnitude. Simply put: your vaccine should not significantly increase cardiovascular risk. It should be absolutely negligible. 1 in a million, whereas these vaccines might be 1 in 100,000.
Inflamed_Heart_Liberal
1yr ago
Also, we have tons and tons of data on "coronaviruses", and SARS 2 is one of those. mRNA nanolipid particle injections? Less experience, to say the least.
Inflamed_Heart_Liberal
1yr ago
No there's a meaningful legal, judicial, and regulatory framework surrounding those vials. And the public health vaccination campaign.
Inflamed_Heart_Liberal
1yr ago
https://youtube.com/watch?v=j_DdSMn55cA&ab_channel=Dr.JohnCampbell
Here's Mr. Campbells exploration. If you're looking for more.
Inflamed_Heart_Liberal
1yr ago
I'm not so sure there's no way to enforce - couldn't non-compliance end up in lawsuits? I agree, but there will be SOME ability to prevent it after a decision against AA.
Inflamed_Heart_Liberal
1yr ago
An induction stove can affect some pacemakers if someone is COMPLETELY up against the stove and the pot is not covering the pad completely. Touching the pot creates a circuit (a long touch), and the pace maker will switch modes.
Interesting share.
Inflamed_Heart_Liberal
1yr ago
Most of my vitriol came from my education. I've been wear of mRNA since summer 2020 when it was announced as a candidate. I've taken undergraduate STEM, but most importantly, I worked with "science and technology studies," where we looked into a century of scientific ethical dilemmas.
So many people got the vaccine when they were told it would stop transmission - I had read the original clinical paper, and saw this was a messy conclusion. Then data from Israel came out that protection was waning, then the censorship began, and later on the mandating piggy backed on the censorship of waning efficacy.
Inflamed_Heart_Liberal
1yr ago
Well yes. But those last hold outs were the hardest to get. They resisted the "the vaccine protects you from other people" misconceptions of herd immunity being pushed. It's an important percentage, and without mandates, the data gaps would have been ammo for the "dissenters" of public health.
Inflamed_Heart_Liberal
1yr ago
Agreed. I personally have a high esteem for many people on both sides of the issue - that's what makes this query so incisive and important.
Inflamed_Heart_Liberal
1yr ago
Yes, they say it's unlikely - but it's possible. SO now that we've established, it is unlikely, but possible that the vaccine can cause harm (which is occult and being undetected in other countries - if this possibility fleshes out).
No change in vaccination practice is recommended
The vaccination process will still be based heavily on a paradigm that humans MUST avoid circulating respiratory pathogens, yet if they must get infect, their best course of action is to take EUA vaccine (of which options are limited and you still cannot acquire an FDA approved and labelled vial of vaccine), at any age. They have said, the possibly the vaccine has a problem is not worth their time changing their public health campaign goal.
The evidence they cite is:
They do not submit any evidence regarding the monovalent vaccine. Yet the bivalent has the same synthetic mRNA transcripts as monovalent. Do we even know if bivalent mRNA is transcribed as a single strand, or seperated into two seperate mRNA molecules?
Not seeing any reason to get vaccinated for omicron, at almost any age or health, with an mRNA vaccine. We need a diversity of vaccines in this country, since efficacy is going to eventually drop for each mRNA boost.
Inflamed_Heart_Liberal
1yr ago
Fair. But during a period of intense censorship, a diffuse cloth of similar anecdotes and experiences actually ended up with some evidence and studies to confirm. Take the myocarditis risk, as well as possible sudden death from myocarditis, being proved experimentally. (check my post history if you interested in link)
Inflamed_Heart_Liberal
1yr ago
https://pubmed.ncbi.nlm.nih.gov/36436002/
Check out this study - you can do an autopsy and link sudden death to mRNA myocarditis. This should help you understand a bit more why such a rare risk is worth your time.
Inflamed_Heart_Liberal
1yr ago
If I tell one student they have stumbled upon "low hanging fruit" when they have a decent response, but I do not say the same to another student, I have created an inequality in speech, a possible microaggression. If they are different races - which race should I be using "picking fruit off tree" metaphors, and which ones would that be offensive towards? I cannot remember where this was presented to me, maybe just a twitter hot take.
This is what microaggressions are purported to be from what I understand. They can be very flexible, which I think we all know..
Inflamed_Heart_Liberal
10mo ago
Inflammation from widely distributed nanoparticles. Look up inflammation, its complicated.
Inflamed_Heart_Liberal
1yr ago
I guess that was part of the show. Vaccines were already so safe and bullet proof, people cannot notice when one that's 10x dangerous is released, and information censored online, and physicians told to be disinterested.
Inflamed_Heart_Liberal
1yr ago
Novavax is a novel virus-like particle. I personally would much prefer Novavax over mRNA, and probably over adenovirus vectors.
I just don't like the threat of heart problems that mRNA presents. Such a large, dark downside to the products, to remodel your heart.
Didn't the Speaker of the House say there should be "uprisings all over." That means when a police station in Fort Green Brooklyn was overrun by a mob, and their vehicles torched with molotovs, it was a violent overthrow of the normal functioning of the judicial branch.
I just think leftists only apply this histrionic analysis in service of their own political goals, you are a great example.
More options
Context Copy link