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Culture War Roundup for the week of January 9, 2023

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CDC has released a report today finding preliminary association between the Pfizer vaccine and stroke for those over 65 years of age.

Another drop in the bucket - or is the bucket spilling out the top now?

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/bivalent-boosters.html

Following the availability and use of the updated (bivalent) COVID-19 vaccines, CDC’s Vaccine Safety Datalink (VSD), a near real-time surveillance system, met the statistical criteria to prompt additional investigation into whether there was a safety concern for ischemic stroke in people ages 65 and older who received the Pfizer-BioNTech COVID-19 Vaccine, Bivalent.

Pfizer is associated significantly with strokes - CDC is keeping us in the dark about the exact data.

This preliminary signal has not been identified with the Moderna COVID-19 Vaccine, Bivalent. There also may be other confounding factors contributing to the signal identified in the VSD that merit further investigation. Furthermore, it is important to note that, to date, no other safety systems have shown a similar signal and multiple subsequent analyses have not validated this signal:

They then list multiple studies that did not replicate this finding for the BIVALENT vaccine - well of course, this vaccine was testing on mice, and then deployed without long term testing. Do they have monovalent data they are not mentioning?

EDIT: Is it possible monovalent risk benefit analysis is simply using a different pathogen, and now with the advent of Omicron, this is a medical update saying this level of strokes is no longer worth the benefit vs the current pathogen? Food for thought.

No change in vaccination practice is recommended.

This contradicts what Paul Offit's opinion is, which was posted in the NEJM. Paul Offit believes we should not give bivalent boosters to young healthy patients.

https://www.nejm.org/doi/full/10.1056/NEJMp2215780

It would be much more shocking to announce a chance to the vaccine campaign, than to keep the current inertia the same. I think we are seeing a communication strategy developing to deliver the population into accepting yearly mRNA vaccines - instead, they will be directed to other worthwhile candidates for vaccination - IF pharma companies can even deliver those.

In my eyes: mRNA vaccines are dangerous, so you need to determine how dangerous the pathogen presenting is. I see a great use case for mRNA developing for Airborne Ebola Zaire strains (90% mortality) or other disease of similar magnitude. Simply put: your vaccine should not significantly increase cardiovascular risk. It should be absolutely negligible. 1 in a million, whereas these vaccines might be 1 in 100,000.

The vaccine debate has to be the least productive of any topic. has anyone on either side ever had their minds changed on this issue despite all the ink spilled? Given how many people have taken the vaccines (billions worldwide) if there was even a small uptick in deaths and other complications, it would be a huge deal and unavoidable. You would not need to comb through huge troves of data to find maybe a tiny uptick in deaths for some small cohort

As an observer of the vaccine debates, its not useful to me on the specifics of the vaccine. I didn't take it and probably wont have to ever, had covid, its over.

But the meta-debate does allow me to calibrate my opinion of who to trust. Whose predictions panned out, who lied, who was okay with lying for the "greater good", etc. Im predicting in the coming years, a lot of people will be vindicated and a lot of people will have pies on their faces. The rhetorical stakes are too high for it to be any other way now.

If anything, atleast now I know who (almost everyone) is totally okay with me being a second class citizen on the premise of refusing certain medication. Some masks are off permanently. Them denying this in the future wont change my opinion of them.

Agreed. I personally have a high esteem for many people on both sides of the issue - that's what makes this query so incisive and important.