VoiceOfLogic
I happen to be, unfortunately, the first human super-intelligence.
What a sad tragedy to see what others can't see.
User ID: 1999
VoiceOfLogic
1yr ago
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synthetic antioxidants can be more potent than the endogenous ones
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many popular polyphenols not only act as direct antioxidants but upregulate the production of some of the endogenous ones.
Hi TIRM,
I believe most "incurable" diseases have their best treatment (not necessarily a complete cure but better than existing) already found 30 years ago but since then completely ignored.
It is fascinating how self victimizing (sorry for the offense but it morally needs to be said) victims of chronic disease are. They just simply believe it is a fatality and trust so called "experts" practitioners that are pubmed illiterate and don't actually give a fuck about your condition.
A victim of a chronic disease should for him and for others systematically try most of the treatment candidates and especially all the treatment that have a negligible rate of serious non-transient side effects.
A disease being considered incurable generally simply means epistemologically that nobody has yet attempted said systematic experimentation.
In many cases nobody will for the centuries to come.
So IIRC from my meta research, for tinnitus the best thing to do is indeed to prevent it, e.g. by taking NAC.
Once the damage is done, NAC does not help. However if your tinnitus is degenerative, NAC will probably reduce the long term worsening.
Now about treatments for someone that already has a (stable) chronic tinnitus:
Firstly about the palliatives:
People use benzos/gabaergics for tinnitus AKA gaba-A subtypes.
I would consider experimenting with Etifoxine (+TUDCA and look at CYP interactions) instead as an alternative with apparently less tolerance building.
Note that a benzo addiction reversal can be accelerated with (Imidazenil or flumazenil? Don't recall) but that process is possibly neurotoxic and ironically ototoxic.
Now about the real treatments:
Unfortunately for you I have forgotten about many things regarding this condition.
Tinnitus is in essence of special form of excitotoxicity.
Therefore the use or gabaergics is probably not only palliative but also to some extent therapeutic as the excitotoxicity possibility drive a worsening over time.
Unfortunately gaba A and B are subject to relatively quick tolerance.
As I said optimality in tolerance reversal and in tolerance building is to fine tune, e.g. Etifoxine.
One could also alternate between gaba A and B or between A subtypes via biased agonism. This might however not necessarily work well and induce cross tolerances although I do believe alternating A and B is not absurd.
GABA also has other receptors which is the point of Etifoxine since it target the mitochondria gaba receptor (although its upregulation of neurosteroids do agonise gaba A and (B?) IIRC)
As said playing with the half life might alter the speed of tolerance building.
There exist other GABA receptors, IIRC tofisopam partially potentiate GABA Y and without tolerance but how useful that is is an unknown.
Tofisopam while having questionable effectivenes as a gabaergic has studies showing it as useful being a potentiator, an augmentation to benzos effectiveness while allowing to reduce tolerance increase.
Also there are alternative ways to induce gabaergy, e.g releasing agent, reuptake agent, prodrug, catabolize inhibitor, etc
However the main salient thing is to look at other beyond gabaergy is the other complementary ways to reduce excitotoxicity.
The #1 to try IMHO (not by potenty but by likelyhood of being useful) would be an NMDA antagonist such as Memantine.
Then maybe concomitantly a calcium blocker.
I have no knowledge in AMPA blockers/negative allosteric modulators.
Kainate and glurs would probably be toxic.
I haven't looked into it but Glycine 4g sounds helpful since it is inhibitory.
You could also play with the secondary messenger inositol at megadoses (unsure about side effect profile), that is an atypical effective anxyolitic and possibility an atypical promising tinnitus treatment.
You could play with vasodilation e.g. Cialis.
Finally you could play with synaptotrophics such as magnesium l threonate.
However of all of that, except for GABAERGY, NMDA antagonism and maybe vasodilation, I don't know empirical studies about those on tinnitus. I conjecture those would be useful based on my expertise. Especially curious about inositol or maybe sigmaergics like opipramol or lthreonate or Etifoxine.
Synaptotrophics are the only really potentially dangerous class, which they are usually not but tinnitus is special so..
The japaneses have however beyond conjectures, empirically found ones that apparently works.
Wether those results reproduce is something you should confirm us.
I would try first Bifemelane
https://www.jstage.jst.go.jp/article/jibirin1925/86/12/86_12_1799/_article
This drug is very interesting, it is a RIMA so the best class of antidepressants, with very minor side effects contrary to MAOIs, see e.g moclobemide or pirazidol.
I don't know any online seller of it.
So you best chance is a trip to Japan for a month or to convince Vanuatu international pharma to get it (good luck..) or to find a cooperative Japanese guy or to ask a japan e-pharma to get it, e.g. contact
I think it is the most interesting tinnitus treatment candidate.
I don't think that another RIMA would work though, there is probably something special about bifemelane. But maybe you could try if you have nothing else to try, moclobemide.
Then we have very ironically tofisopam, with a very high efficacy score
https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_133/_article
You should definitely try it. I doubt it reproduce but I mean the efficacy score is record high, the side effect profile and cost negligible and the action mechanism (special PDE inhibition and GABA Y) is actually unique in the world.
Titrate dose slowly up to the study dose and if no results above up to the max dose (300 IIRC?)
Wait for 5 weeks before concluding about no efficacy.
And then report back.
I would recommend getting the official brand OTC e.g. on rupharma dot com
Then after trying tofisopam I would try the many other compounds that have positive efficacy results albeit milders
E.g. IIRC pge1
https://www.jstage.jst.go.jp/result/global/-char/en?globalSearchKey=Treatment+of+Tinnitus
And also not just pharmacology but behaviours such as
https://www.jstage.jst.go.jp/article/audiology1968/44/3/44_3_163/_article/-char/en
Edit:
There's also atypical non drug based pharmacological actions,
Such as tVNS
And
tDCS
https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-018-0467-3
BTW not a treatment but an underused palliative for sleep would be ASMR
Then if nothing of all tolerable treatments that have been empirically found over the last decades does bot work for you then I would consider actively joining clinical trials or preclinical trials or to ask for the
https://en.wikipedia.org/wiki/Right-to-try_law
You could also become an expert and conjecture yourself an priori optimal polypharmacology like I did but better than I did since I haven't studied the precise nature of the excitotoxicity/long term potentiation.
E.g if it was epigenetic then one would consider e.g. HDAC inhibitors
EDIT
this action mechanism seems potent
https://pubmed.ncbi.nlm.nih.gov/17221143/
EDIT additional treatments:
for pge1
"Misoprostol"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136369/#::text=treatments%20(217).-,Misoprostol,-Misoprostol%20(Cytotec%C2%AE)%20is
"However, the combination of sulpiride plus melatonin, which interacts with dopamine receptors, reduced tinnitus visual analog scale scores significantly more than placebo (275–277). In a single-blind, placebo-controlled study, sulpiride plus hydroxyzine, an antihistamine and anxiolytic, was significantly more effective in reducing tinnitus visual analog scale and tinnitus perception scores than placebo or sulpiride alone (278)."
Edit:
Potassium channel modulators looks interesting
Vigabatrin too despite possibly permanent side effect profile
Gacyclidine could be better than Memantine
Same for neramexane and AM-101
I guess one should try all tolerable nmda antagonists to find the one that works best on him
It's possible that nmda antagonists take time to show effectiveness
See e.g this atypical one
Acamprosate had no beneficial effects after 30 days of treatment, a modest benefit at 60 days and a significant effect at 90 days.
Nice resource btw
https://github.com/aioue/tinnitus-treatments/blob/master/to-be-sorted.md
"2.2.5. Primidone"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#::text=day%20%5B33%5D.-,2.2.5.%20Primidone,-Primidone%20is%20an
"Furosemide"
"Intratympanic Steroid Injection"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#::text=2.12.9.%20Steroids%3A-,Intratympanic%20Steroid%20Injection,-Intratympanically%20injected%20steroids
With so many treatments and the obvious potent synergies between them, I strongly believe you can strongly reduce your tinnitus.
TL;DR
Start with tofisopam, Etifoxine and pge1.
Etifoxine must be taken with TUDCA and ideally liver enzymes should be monitored although optional.
Verify about the cyp interaction iirc tofisopam and Etifoxine inhibit the
women rate him less attractive than men
Interesting, sauce?
VoiceOfLogic
1yr ago
Maybe unrelated to your needs but I believe people waste too much human resources on niche low level languages like C/C++/rust (I've extensively learnt both BTW) and could get much more proficient and expert in their job language instead, such as Kotlin which is the sweet spot IMHO.
VoiceOfLogic
1yr ago
Nobody can ever define what "understanding" means
This is an appeal to ignorance.
Understanding something is having a causal model of it.
It allows to analyze such system and reliably predicts it and its consequences.
A system with a reliable understanding should be able to output argumentative text/syllogisms showing said understanding, free of logical fallacies and with source to the truth values of the premises.
To mysticize what understanding is really shows once again the truism that epistemology should be taught in schools.
The point is, it does not matter whether you think it is really really deeply understanding, as long as it is capable of accomplishing goals and having real impact.
At the end of the day, the result is what matter indeed, but without understanding a system is non-reliable and cannot be trusted for many serious needs.
VoiceOfLogic
6mo ago
Tendons.. nobody knows shit about how to fix them
Well the thing is simply that doctors are scientifically illiterate, unlike me. The most potent drug at repairing tendons is BPC-157 which is a peptide endogenously produced in the body. It is available OTC for a short term injections cycle, the most reputable website but a bit pricey is peptidesciences .com https://pubmed.ncbi.nlm.nih.gov/14554208/ BPC is quite popular on /r/peptides and has "saved" many, however it is a serious medication that shouldn't be taken without studying its tradeoffs (short term anhedonia risk, amphetamine blunting and increased angiogenesis (therefore increased lifespan if young, increased risk of metastasis if old)
As usual men are doomed as they are in large amounts, simps or to some extent, endoctrinated self-hating misandrists. Note however that biologically speaking there are reasons for the shorter lifespan of men though, the biggest one probably being height. height is one of the strongest predictor of low life expectancy. Basically anabolism has costs, including some immuno deficits in terms of resource allocation, possibly increased oxdative stress and cancer risk. It might be that short and non-high bmi men live longer than the average woman though? But mens body also has advantages, for example increased brain volume means men are less prone to neurodegenerative diseases, especially for example, 2 times less chance of developing multiple sclerosis (although the specific reason here being that testosterone increase myelin production)
Now as a reminder, you can increase significantly your lifespan via skq1.
However the biggest omission in your blog, and the question that leaves me most curious, is a comparison of women/men not lifespan but healthspan I already talked about dementia but what about sarcopenia (should advantage men too) and what about chronic hospitalizations rate per age? I suppose the gap of ill men (especially cancer) is even bigger than the gap of prematurely dead men.
Also a question no ones asked before, are baby boys more often victims of baby shaken syndrome by their parents?
VoiceOfLogic
10mo ago
what's the point of this versus reddit truerateme and similar? (to be fair true rate me has a cringe craniometric notation scheme but there are other subreddits)
VoiceOfLogic
1yr ago
Only ukrainerussiareport will show the true Ukrainian military hardware losses which is necessary to have predictive power and when/if its defense capabilities will break down.
Ukrainerussiareport is mostly not propaganda btw, much less so than are the other subs, especially since many commenters are pro-ukrainian which give a certain rare balance.
VoiceOfLogic
1yr ago
Sorry what does HBD mean?
VoiceOfLogic
1yr ago
Just saying:
installing software dependencies to run it is very simple you can learn it in 15 minutes.
It depends on the environment but e.g. for the popular Javascript command line applications you need to install the Javascript virtual machine (NodeJs), it will install for you Npm, the node package manager which allow you to install dependencies.
You git clone a JS repository you find cool.
you run npm install
and to run the app it depends, could be npx run or npm run/serve, but that detail is described in the Readme file of the github repository see section how to install/run
For other programming languages, the steps are very similar and straigthforward.
VoiceOfLogic
1yr ago
It's be really nice to have an online collaborative website where we can highlight sentences in books per thematic/criterion of highlight.
We have so much content in this world and the signal to noise ratio is so low, that's the usual ineptia I guess
VoiceOfLogic
1yr ago
I find the health aspects of radiations through induction charging worrying in principle, I have no idea how the potency compare to WIFI/5G radiation though but I would'nt risk it without studying the topic, it is absolutely not reasonable to trust our broken civilization on health topics, especially hypothetical oxidative and mutagenic long term only observable accelerated ageing.
I'm not certain to understand what your goal is with that question,
a pharmacological causative model is heuristically useful to make predictions, about effectiveness for condition X and to establish a safety, tolerance, toxicity and interaction profile.
All those things are useful but mostly unecessary for the layman.
If there is a non-negligible community that takes plant X since years in quantity Y and that doesn't report huge terrifying side effects and that they report potent effectiveness then its probably worth a try for acute use although for long term use there will always be a toxicity/accelerated ageing question but in many cases we never know for certain however in most cases we do know reasonably somewhat the safety profiles.
It has actually become very rare to find phytochemicals that have not been extensively studied regarding their pharmacology and hence the causative model is often well established assuming you take time to research the research.
But beyond annecdtotal evidence, doing a blind test scientific trial about wether X is effective for Y, e.g. depression is very cheap and therefore even without said causative model we often know wether X has elicited a potent response for Y in N people empirically following precise protocol.
Empiricisms as always trumps a priori reasoning regarding effort efficiency and indeed people should considering the mostly safe profile of phytochemicals (generalization see e.g. cyclopamide https://en.wikipedia.org/wiki/Cyclopamine#/media/File:Cyclopelamb2.jpg) play much more the lab rats, this would drive very significantly the speed of empirical scientific research and therefore discovery of treatments for ineptly considered incurable diseases.
edit:
only recently did we learn that tryptophan will selectively unbind with albumin at the blood brain barrier
What does that imply? We already knew tryptophan cross the BBB. You mean the competition with tyrosine?
only recently has the consensus shifted to serotonin deficiency lacking a role in depression (although I have my own views on this).
What?
Serotonergics are euphorisant see e.g. MDMA, MDAI, 5MAPB, shrooms, etc
The effect of SSRIs is less intuitive (reduction of sert receptors density) but still sert driven.
VoiceOfLogic
1yr ago
Right although some glasses have nice to have distortions such as a loop effect that makes your eyes appear larger than they are.
You can always wear contact lenses if that annoys you and optionally change the color of your eyes or make them appears reptile or feline like :)
VoiceOfLogic
1yr ago
No, of course, I didn't litterally mean that there isn't a smartest human on earth (although here I specifically mean maximal debiasing, not about other heterogeneous cognitive abilities), there is one by design, however my point was that human being is sadly not significantly above the other ones in the top. In fact they're quite mediocre and most must reach a deceiving plateau.
VoiceOfLogic
1yr ago
What is the legal identity criterion of textual copyright?
E.g. Let's say you wrote a book.
I take it and change one word.
Is it still your book or is it now mine or public domain?
2 words?
100 words?
Is there a percentage?
Does the location matter?
If i change words mostly at the start of the book or throughout it?
Does semantics matters? Can i via a software replace some words by identical synonyms or do i need to change semantics?
I have no clue how the legal system solves this major problem.
I would probably enforce the use of
the sota in https://paperswithcode.com/sota/semantic-textual-similarity-on-sts-benchmark and set a magic number percentage. Although it can be gamed that's probably much more accurate than whatever is being used now.
VoiceOfLogic
1yr ago
It is important to understand that it is trivial to cure COVID since day 1, the rationalist diaspora, like the medical diaspora are simply extremely illiterate in pharmacology. In retrospect, it seems people litterate in pharmacology are extremely rare.
You can either solve age induced immunosuppression/thymus involution via thymalin OR potently block viroporins OR potently downregulate/block ACE2 receptors OR block/downregulate any other related necessary component in the virus reproduction/action chain.
As a bonus you can also block the toxicity including cytokine storm.
That's 3 independently sufficent class of action mechanisms which all have existing pharmaceuticals.
VoiceOfLogic
1yr ago
I don't think there is any possible kind/good faith interpretation to your question.
It just doesn't make sense and yet it was upvoted by 5 readers..
It should be painfully obvious that economic power is mostly hortogonal to military power, while there is some correlation it is obviously contingent.
It should be universally known and was explicited by one of my comments that China like the rest of the non western world was late regarding the industrial revolution, the design of war/killing machines and the use of powder/guns (which is ironic since Europeans originally imported that tech from China)
I didn't think it was useful to explain those things and why the west was able to militarily dominate the rest of the world.
Also the wars on china were a worldwide coalition of coercive powers, including Russia, the British empire, the French, and the U.S
VoiceOfLogic
1yr ago
I believe there would be many maybe surprising consequences, such as an explosion in social anxiety.
However the no filter effect would have interesting consequences on the group thinks/culture wars.
BTW one of the strangest things of this timeline is that apparently a huge chunk of the population is not able to think or at least they believe themselves they can't think.
Think as in subvocalize words.
I have extreme skepticism on this phenomenon but if true it has many implication for AI research and philosophy.
In other words it might be that for a chunk of the population there is not thoughts to read at all.
However, one could talk about telepathy for the intermediate subsymbolic representation but that's not what your original comment was about and is definitely much less well defined, by definition since it is ineffable.
Excellent find, I wish there was a subreddit for obscure quality rabbit holes like this.
or ya.ru
I appreciate the mention of yandex, it is something that is easy to forget but google only shows a chunk of the internet, unfortunately I don't speak russian but yet I was able to find a unique find, inexistent on google, the roadmap towards the VVER supracritical nuclear reactor, coming this decade (IIRC) and that will disrupt nuclear fission economics.
BTW
how did you find this website?
Did you notice the main page?
https://hwlabadiejr.tripod.com/ENIGMAS.HTM#TOC
The author has made a whole book apparently
here's his (was?) email address hlabadJr@aol.com
I wonder what Horace W. LaBadie, Jr. is doing nowadays, would love to see him go on substack :)
Also one might be interested in using a "website auto explorer", a tool which automatically find sub-URLs on a website.
Hi, thanks for the heads up.
I agree I said the claim of racism with a bit too much insistance and that I shouldn't have used a universal quantifier "no one"
In case it wasn't clear, it was a figure of speech, I'm obviously not claiming at all litterally that no one knows about the slavic genocide but it is an emphasis to make people realize how strikingly underknown, undertaught and undertalked it is.
Context is key, did I say straight out of nowhere that the person I'm answering to did not know about the slavic genocide? No,
My initial comment was a question:
I invite the reader, for example, to ask himself if he knows what was the biggest genocide during WW2.
Then the person answering mostly failed the test as there was no mention of the slavic ethnicity being twice as big as the jewish ethnicity, which is the salient and useful fact.
They have mixed up the term holocaust (jew only genocide) with other ethnicity which hide the salient fact and defeat the purpose of the question.
Although my two salients statements, that china were induced extreme suffering because of the west especially fertilizer ban and unfair treaties, and that the biggest genocide concern the slavic ethnicity, are example of an asymetry in what matters to people from the west, the differentiating factor between slavic and jewish is none except the possibility of differential racism.
Therefore this asymetry of reporting and of caring of human suffering and of responsibility is an evidence based example of racism mechanisms or at best ethnicity selective apathy.
It would be hypocrisy to not admit to the asymetry of public commemoration between the two genocides. Shoah is a worlwide topic that is a basic fact.
Another piece of evidence is that I was mostly not taught those facts in my standard school (France) or they were mentionned for a minute.
The litteral title of the scholar paper research I linked on the slavic genocide is "The forgotten Holocaust"
I'm sure that make much more evidence than needed to get the point and have a civil discussion about it. But alas, people are polarized.
Yes some people in this community knows about those historic events contrary to my lazy claim however it is very likely that for the rest of people it should make them question their information feeds and their opinons about worlwide justice. Hence a rare and useful contribution.
Again I will avoid needless universal quantifiers in the future.
I wish people would come with intellectual curiosity and good faith.
pedantic note:
you're taking an unpopular ideological position
I am not doing any ideology here and I have stated no defense or approval for the PRC.
I am stating facts that can hurt beliefs in the anti-sino tribe. That does not make me a part of the pro-sino tribe.
I'm interested in reality, not ideological sects.
VoiceOfLogic
1yr ago
This is false and a cheap trick for gaining attentional emphasis.
Of course it is a truism to understand that medias often use omissions and quantifier alteration.
It might be more frequent than straight lies however the media do lies often about basic facts and as such it is not rare let alone very rare.
A common straight lie for example is to claim that there is no scientific evidence about something or to claim there is a single and consensual scientific voice about something.
Those straights lies (just one example among many) are very frequent and potent.
VoiceOfLogic
1yr ago
Until you run in a situation you never encountered before as the world is highly variadic and then the system pathetically fail.
America is diseased, rotten to the core.
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