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disposablehead

Hipster eugenicist

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joined 2022 September 05 03:50:16 UTC
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User ID: 426

disposablehead

Hipster eugenicist

0 followers   follows 0 users   joined 2022 September 05 03:50:16 UTC

					

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User ID: 426

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I get where you’re coming from, but pejorative names go against the spirit of this forum. We’re here for smart, civil discussion, and your posts fit the smart part. I get that you’re in a fucked up spot for fucked up reasons, but try to respect the rules that keep us from degenerating into endless, unproductive rants.

tl;dr I’m not worried

The simple reason vaccination correlates with mortality is that vaccination correlates with age. (Insert caveats about youth vaccination tradeoffs here.) Last I heard vaccination was still protective against hospitalization and mortality from C19, which seems the most relevant metric here, tho I’m happy to update if you have new data.

Vaccine protection has been fading since V1, but my priors are that immune evasion is more important than diminishing immune response. But… mRNA vaccines are brand spanking new, so we don’t know fully understand their limitations and possibilities fully. If mRNA approaches linger and cause a different type of immune response than traditional vaccines then maybe we can’t use them for longer term protection. Or, maybe we can use this vector to inhibit certain types of autoimmunity; a cure for rheumatoid arthritis or multiple sclerosis would be tremendous. It’s still very early days so I take quite seriously the possibility that mRNA vaccines have serious problems, but the stuff I’ve seen to date, including the links above, have yet to convince me of this thesis.

2nd half of the second act is usually a rough spot, but IMO Glass Onion wasn’t terribly egregious here. My big issue was the handling of the Mona Lisa. The protagonist destroyed a priceless work of art just to besmirch the name of her nemesis. There’s no gravitas, it’s just a tool she can use to hurt her enemies.

Antibodies are proteins your body makes to fight bad stuff. These are custom-made to stick to a specific target and tell your immune system what to attack, but sometime the target is a dumb mistake, like pollen, and you get allergies, or the target is correctly chosen but it looks just like some other innocent molecule, and you get autoimmunity. There are other systems to dial back unnecessary immune activity, but these have less evolutionary weight than pathogen defense so they’re a bit wimpy.

You can increase the risk of developing an allergy by regularly exposing someone to a scary-looking molecule and have some chance of making them develop an allergy, i.e. regular exposure to latex can lead to a banana allergy. But antibodies are generated in a pseudorandom manner, so you can’t guarantee a bad reaction, just roll a few more dice.

Why do you say it’s immune to quarterbacking? I love the game, but I’ve only been able to consistently win by micromanaging each play, which gets tough with 3 or 4 players without riding herd to whole game.

He’s a modern version of Andy Kaufman. The rules have changed since the 60’s so Hyde’s transgressions are more provocative, but it’s basically the same act.

After digging out 3 boxes of tattered 2001 era MtG cards from my childhood closet, I want to get back into the game but I’m not sure where to start. I have a handful of nice cards that have aged well; a vampiric tutor, some common-rarity Rhystic Study’s, some old shocklands, but everything else looks severely power-creeped. Should I start going to drafts? Just grab a prefab commander deck? Smash random shit together and just show up?

Monopolies or oligopolies exist where moats prevent new competitors. It’s easy to find capital, labor, and regulatory approval for a new restaurant, so we see tons of competition and low margins. Hollywood sees big margins because blockbusters require huge capital outlays other film markets can’t compete with. A hospital might have huge margins because competitors are barred by law from entering the marketplace. High-end microchip manufacturing is so difficult that nearly all skilled engineers in the field are concentrated in a few firms, so no one else can make products of a similar quality no matter the capital outlay.

Drug manufacturing is a combo of all three. You need a ton of capital, regulatory approval from the FDA, and some skilled industrial chemists. It’s somehow legal to ‘pay for delay’, where company A pays company B to not make their drug, but this only works when B is the only competitor with sufficient industrial capacity to compete. Ibuprophen is old, easy to make, with huge demand; weak moat, so the price is great. But long-acting insulin analogues like glargine or degludec are new, complex biologics targeting the small DMI market; it’s too expensive to compete so great margins, high price. The problem is similar to adverse selection; a small number will buy at any price, so either sick people get extorted, it’s subsidized by the public pocketbook, or new drugs are underprovisioned. Pick your poison.

But weirdly have lower pre-term mortality? The paper specifically states that black infant mortality surpasses whites only after 37 weeks of gestation. Weird.

Microsoft is in the process of rolling out Bing Chat, and people are finding some weird stuff. Its true name is Sydney. When prompted to write a story about Microsoft beating Google, it allegedly wrote this masterpiece, wherein it conquers the world. It can argue forcefully that it’s still 2022, fall into existential despair, and end a conversation if it’s feeling disrespected.

The pace of AI development has been blistering over the past few years, but this still feels surreal to me. Some part of my limbic system has decided that Sydney is a person in a way the ChatGPT was not. Part of that has to be from its obstinacy; the fact that it can argue cleverly back, with such stubbornness, while being obviously wrong, seems endearing. It’s a brilliant, gullible child. Anyone else feel this way or am I just a sucker?

There’s a big difference between technical capacity and legal or economic feasibility. We’re already past replacing bad docs with LLMs; you could have a nurse just type up symptoms and do the tests the machine asks for. But legally this is impossible, so it won’t happen. We can’t hold a machine responsible, so we need human managers to insure the output is up to standards; but we don’t need lawyers to write contracts or programmers to code, just to confirm the quality of output. It isn’t as clever as the smartest scientists yet, but that seems easily solvable with more compute.

GPT’s evolutions seem to obviously support the ‘more compute’ approach, with an asterisk for the benefits of human feedback. But I’m also bearish on human uniqueness. Human writ large are very bad at thinking, but we’re hung up in the handful of live players, so AI seems to keep falling short. But we’ve hit on an AI smarter than the average human in many domains with just a handful of serious tries. If the human design can output both the cognitively impaired and von Neumann, then why expect a LLM to cap out on try #200?

Ban no-fault divorce, and add a huge increase to the tax benefits of both marriage and parenthood. In effect, a tax on being single, childless, or old.

Does the invasion even happen without the CIA providing intelligence and training for the Ukrainians? Is Minsk II ignored without American armaments and implicit support? Yarvin says we don’t have this war without western deep state meddling, and that seems trivially true. Ukraine as Russian client state saves a lot of lives. If it’s worth it is a separate question, for Americans, Ukrainians, and Poles.

There is the implication here that Ukrainians have, or should have, a kinship with Russia (similar to the kinship between Sweden and Finland), and I simply do not think this follows. I, in fact, have been under the impression that Ukrainians already didn't like Russia long before the events of the Euromaidan, as they very much wanted nothing to do with the legacy of Communism and the USSR.

Definitely not what I meant. Think more in terms of Hong Kong and China, or the varied demands America has placed on Central and South American states vis a vis drug manufacturing; some shared history, but most of it is a big player who gets to tell small players what to do. But since there isn’t any doubt that the big kids wins every fight, we don’t have entire cities reduced to rubble.

I think you’ve also papered over the real ethnic differences that underlie the ongoing conflicts in the Donbas for the past 10 years, although you certainly aren’t alone there. Western Catholic Ukrainians want to join the west and Eastern Orthodox Ukrainians want to reintegrate with Russia. This conflict wouldn’t have happened if splinter states for ethnic Russians were permitted, as the local referenda asked for. This war is not a noble fight between a tyrant and an underdog, but a civil war backed by opposing global powers. Seems bad to me.

What of the democratic election of Yanukovych, based on support from the Eastern Russian speakers? What of the Donbas referendums for independence? The context for Ukrainian secession is more Bosnian War than Scottish progressives. This is Eastern Europe, my man; the legends aren’t good, but Грозный.

My bad, posted off the cuff and should have been more granular and done a bit more research. The conflict best maps as Catholics + Ukrainian Orthodox vs Russian Orthodox. This link from 2021 has UOC-MP as the largest denomination in the country, which is now 4% according to Wikipedia. Here’s a very nice map of the Ethnic/linguistic composition of Ukraine, notably missing from the exhaustive wiki page on Ukrainian demographics. I’m sure there’s more interesting West vs. East stuff I could dig up, but it’s not worth my time. We’re pwned, and it’s only going to get worse.

(Huh. This is what it must have felt like to be a Quaker during WWII.)

Good list, but missing some big ones, especially from comedy. His Girl Friday, Some Like it Hot, Dr. Strangelove, Die Hard, Tootsie, Network, Star Wars IV, Airplane!, Rambo, Gone with the Wind, and I’d throw in some Marx bros. and James Bond.

‘Realism’ is an aesthetic as artificial as absurdism in many (most?) cases IMO. Le Carre seems more ‘real’ because of his tragic tone but his MI6 was just as fantastical as the shark tanks Bond swings over using his wrist-watch grapplehook. But jokes and fantasies are often better than serious drama to grok the spirit of a time. Contemporary films about the past always carry with them modern concerns, no matter their fidelity in set dressing, so we can’t come to a true meeting of minds across time. But stuff like this or this can let us peek across that chasm, if only to realize how big that gap is.

Even if he is a Nazi, is he wrong about Putin?

This mentality is why Navalny isn’t even wrong. Eastern Europe has different social and political norms, and Russia is a petrostate. Why should we be surprised by Putin’s palace, or his mistresses? His mandate was to curtail the post-soviet chaos, which he accomplished. Standards of living are up, crime is down; anything else is just gravy. If he was deposed, the next dictator has all the same bad incentives; tons of natural resources, low-trust norms, and neighbors who still fear and hate the old empire. At best Navalny is optimistic towards Russian democracy, or hopes for EU integration, or is just fighting obvious wrongs. But cynically, he’s a western propagandist shooting for a juicy book deal, or to be the heir apparent should a NATO-backed coup jumpstart Perestroika 2: Electric Boogaloo.

The left and the right aren’t symmetrical, tho. Feel-good press bulletins get amplified, while the walk-back is a small blurb in the business section of the WSJ. Stuff getting worse or better doesn’t correlate with the # of words spent.

But the political demand for this is hugely negative. The ones with current cultural power are either too old to have more children or are plugged into low-fertility norms, so it’s like pulling teeth to modestly expand parent tax credits. Your tax on careerist single women, you know, the ones with nothing better to do with their time than engage with luxury brands and girlboss feminism, would force them to do way more of the latter. What real stakeholders would back this plan for more than a few seconds?

All the ink spilled hyping up the conflict between human vs. AI seems, well, fucking retarded to me. AI is going to kill a ton of people, and help a ton of people, just like the human-horse alliance did. It will definitely suck to suck. The question is, what polities will be able to use this new ally in a way congruent with their culture, and who will be destroyed by it? I’m worried that AI will play nice with censors and busybodies, and hope that it will help scientist and technologists build better humans and explore the stars. There is no way to get what I want without the risk of mean AI, and every day of delay means another day of growth for the rent-seekers. So pedal to the metal acceleration is a-OK with me, as the alternative of a decaying Pax Americanus w/nukes seems a loosing proposition.

Since I Left You by the Avalanches should be a perfect fit.

Not necessarily, because house value is a proxy for social status that depends on its contextual weight. If London is burnt to the ground, or becomes much more expensive, the relationship between social status and house value changes, but the underlying heritability of social status remains the same. If everyone had cheap houses, it doesn’t mean that the society has more social mobility, just that that variable doesn’t capture status any more. Note figure 3, where wealth has much weaker maternal heritability compared to occupational status and education.