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Notes -
Inspired by another poster who wrote about misadventures with Tylenol, I just want to provide a brief commentary on medications.
More medication is not necessarily more better.
Many medications essentially work by targeting a receptor of interest or receptors of interest.
If you double the dose you might go from 95% of the effect you want to 98% of the effect you want, while also saturating other receptors that cause side effects.
For ones that are more receptor specific (like Ibuprofen (Advil)) we find that things like doubling the dose from 400 to 800 has little impact on pain, more of an impact on anti-inflammatory properties, and a massively increased risk of side effects.
Don't just take a handful of pills expecting more to do more of what you want!
Here's everyone's daily reminder that the standard melatonin dose sold (10mg) is literally 100x too strong. 0.1mg is much more effective.
Welllllll no.
I know Scott's article makes a case but it's way more complicated than that.
Sleep medicine, Psychiatry, and PCPs all have wildly different views about Melatonin all of which can be simplified as "sure, fine, it's safe" but a lot is happening under the hood there.
Some evidence it does absolutely nothing.
Research is complicated because anxious college students, the elderly, someone in a Psychiatric inpatient unit recovering from an episode of something, and a 40 year old man with a bowel perf in the hospital all have wildly different sleep needs and problems. Makes research very hard.
Then you add in the stuff like spaced dosing being more effective...
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