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We've been doing detailed studies for 80 years!
And we still have this deep confusion about whats going on. Citing an old SSC post:
This confusion is kind of my point. The lipostat hypothesis is still a bit controversial after 80+ years. If a "set point" for weight truly exists somewhere in the system, it's still not clear what raises this set point, and why lowering it again seems extremely difficult.
There's plenty of studies that indicate that once the set point has been raised, it can't be easily lowered again. This is, funnily enough, contradictory to your 1965 study (unless the 400 lbs -> 200 lbs guy was short, and 200 lbs was still obese). Or maybe only more modern food additives raise the set point permanently? I don't think we know, and almost nobody (relative to how important those questions are) seems to actually test things on large groups of people.
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Some other Scott quotes. From "Book Review: Good Calories, Bad Calories":
And from "Contra Hallquist On Scientific Rationality":
Reading those Scott quotes makes me wonder if the idea of a "set point" has just been tainted by association with low-status people, much like his observation on how Alex Jones latched onto a real environmental effect and turned "they're turning the frogs gay" into a national joke because people think he's lame.
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