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Recently on LessWrong: Estrogen: A trip report
(Yes, he's treating estrogen HRT as the type of psychedelic drug that might necessitate a "trip report".)
There's a lot to sift through here, but the most interesting part of the post to me was being introduced to the concept of the schizotypy spectrum, a related-but-distinct counterpart to the autism spectrum. Autistic traits and schizotypal traits both have similar outward manifestations (e.g. introversion and difficulties with social interaction), but they have different root causes and different internal subjective manifestations (principally, autistic types are higher in detail-orientation, and schizotypes are more prone to disorganized and delusional thinking):
The author of the post then goes on to claim that, subjectively, estrogen caused him to experience a shift away from autistic traits and towards schizotypal traits:
Obviously this all has to be taken with a grain of salt, because the risk of confounding factors and psychosomatic/placebo effects in this case is high. Nonetheless, I'm curious whether pre-existing schizotypal traits in an individual (contrary to the author's experience in which HRT induced these traits) might play a causal role in explaining the abnormally high incidence rate of MTF transsexuality among so-called "terminally online" young men. By "terminally online" I mean the prototypical image of this demographic: likely to be in a STEM field, likely to have had little romantic success with women, likely to have obsessive "nerdy" interests like anime and video games, etc. This demographic is often stereotyped as "autistic", although that label may potentially conflict with the fact that MTF transsexuals are disproportionately drawn from this demographic as well, since it's not clear a priori why a disorder that allegedly gives you a "hyper male brain" would also make you more likely to want to be a woman. But if some of these "autistic" men actually belong to other personality clusters that have a tendency to masquerade as autism, it could help us build a higher resolution mapping of this region of cognitive space and provide more accurate explanations of the trajectories of different individuals (especially because one of the schizotypal traits is, as mentioned previously, a predisposition towards delusional thinking).
Regardless of which theory ultimately turns out to be correct, I think the biological basis of LGBT traits (or at least, which intrinsic traits increase one's predisposition towards being LGBT) is a subject that deserves further study. In my experience, anti-wokes are more likely to entertain the possibility of race and sex differences being biologically intrinsic, but they shy away from applying biological explanations to LGBT, preferring instead to endorse social constructivist theories (and in particular, the "social contagion" theory for transsexuality). Wokes are the opposite, heavily opposing biological explanations for race and sex differences but somewhat warmer towards biological explanations for LGBT (although they may not allow themselves to present it in exactly those terms). I prefer the simple, consistent position: it's all (at least partially) biological! Social contagion is undoubtedly a part of why the incidence rate of transsexuality has skyrocketed in the last several decades, although I think it's clear that only some people are susceptible to "catching" the contagion in the first place, and one's individual susceptibility is biologically mediated.
I think that this "estrogen cures autism" analysis is false, for the simple reason that this reads like confirmation bias and (ironically) an attempt to systematize the effects of estrogen in a way directly counter to any notion of the author becoming less autistic. That being said, I'd assign something like a 1-5% chance that they're onto something, and that something would be really interesting if it was true, so for a bit I'm going to be arguing from that perspective.
Before anything else, let me establish that the "problem" with autism is difficulty communicating .That predictably leads to social deficits and-- guess what-- trans people report high levels of social isolation and loneliness (This figure includes FTM trans people too, which aren't what I'm talking about with autism, but I'll get to that later). Meanwhile, estrogen increases oxytocin and oxytocin reducing autism symptoms and oxytocin decreases the felt impact of social isolation. So immediately, there's a pretty compelling link between autism->feeling lonely->taking estrogen->feeling better that explains the "success" of the trans phenomenon, including the high rates of treatment satisfaction. This blog post goes one level deeper, and proposes an autism-schizoid axis that underlies the taking estrogen-feeling better link... and additionally, explains why trans people feel better even without taking hormones. Namely, if their problem is an excess of autistic traits, even just adopting the cultural behavior of a more schizoid culture is enough to make up for part of their social deficits-- and joining a dedicated community focused on doing the same thing reinforces that effect even further.
FTM trans people don't really make sense if you assume that autism compensation is the mechanism of action for transsexualism, but with the autism-schizoid axis they start to make more sense... being schizoid causes it's own form of social deficits that presumably testosterene helps compensate for. We know that testosterone encourages altruistic behavior under certain circumstances... I'm not sure how that would help it counter schizoid personalities, but it's certainly suggestive of something going on.
Put all that together with the fact that transexualism has increased pretty much in tandem with the simultaneous rise of autism/ADHD diagnoses and hormone disruptors like phthalates, microplastics, high fructose corn syrup, etc. and you can put together a comprehensive, self-consistent explanation for why this entire social movement in happening.
Again, I don't actually believe the article. Even if the author is right, I think their methodology is so wrong as to be useless. But it is interesting, and for that I have to respect it.
A high number of FTMs I've known have at least stated they're autistic. While autism among the female sex is controversial, I suspect they're correct. I have no data for this, but I think the two greatest risk factors for FTM transitioning are 1) autism and 2) PCOS. I have a friend with PCOS who is a huge fan of Abigail Shirer, and believes that a great number of FTM transitioners are women with the same syndrome -- which is caused by abnormally and dangerously high levels of testosterone in women -- who feel like the symptoms of the condition like male-pattern hair growth and irregular periods make them less of a woman and therefore seek to embrace them as part of their "true self."
This is perhaps analogous in some ways to AGPs and transwomen more generally who are bullied or ostracized for femininity and come to believe that they really are a sissy loser who can't be a man and might as well embrace the only gendered path that seems possible for them.
Actual bona-fide gender dysphoria obviously plays its role, although I wonder sometimes if much of it isn't so much active identification with the preferred sex and more a feeling of alienation and incapability to be accepted as a member of their birth sex that emerges into body image issues. That would make it something that social contagion can affect, much as anorexia can take even subtle (or not so subtle) social cues towards physical fitness and thinness and transmute them like a witch into an inability (Edit: originally there was a typo here that was "anability", which is an uncomfortably good phrase to describe the perception problems of anorexia) to accurately perceive the body's actual thinness. Obviously not all cases, but I think transgenderism is a multi-factor phenomenon and this might be one of the factors.
People sometimes conceptualize transitioners as villains or attention-seekers, and sometimes they can be like that, but I strongly believe there's a wellspring of intense suffering that motivates it in many cases, even if we don't have to affirm every decision that someone who is suffering makes or even agree with their interpretation of their experience.
Yeah, that's part of the reason why I'm only assigning a 1-5% probability of this being true. I could come up with an argument along the lines of, "autistic women do better with men than schizoid women" but that has its own problems.
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