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PaperclipPerfector  2d ago (text post)   1717 thread views

Small-Scale Question Sunday for July 20, 2025

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so the liver only has to do about half of the work, comparatively speaking.

HFCS is usually also about half glucose (by dry weight).

The most common forms of HFCS used for food and beverage manufacturing contain fructose in either 42% ("HFCS 42") or 55% ("HFCS 55") by dry weight, as described in the U.S. Code of Federal Regulations (21 CFR 184.1866).[5]

HFCS is IIRC pretty darn similar to honey in terms of sugar composition. And if you think fructose is the enemy specifically, there are "healthy, natural" options advertised with higher fructose content.

I ran into this a couple years back reading up on DIY endurance nutrition: the quick, cheap recommendation is usually a mix of maltodextrin (long-chain glucose polymers, used in home brewing fairly often) and something high in fructose (typically agave nectar) because the two metabolic pathways are largely orthogonal. That said, those results are largely applicable to specific circumstances resembling "how many calories can I usefully consume while running in warm weather", not general nutrition advice.

You're right! I had to refresh my own memory on this some more and the additional detail that my brain was fuzzy on in the intervening years is the whole disaccharide vs. monosaccharide bit, meaning that because regular sugar is a disaccharide, the bond between glucose and fructose has to be broken, whereas HFCS contains free monosaccharides. I kinda remembered that sucrose took a bit more work by the body to digest, but I was misattributing that to the balance of sugars, which as you're pointing out, isn't really much different than regular table sugar. So to be clear, it's not the amount of glucose vs. fructose itself, the idea is that the free monosaccharides of fructose in HFCS are uniquely taxing to the liver in a way that regular sugar is not because the bonds on sucrose have to be broken before the fructose in regular sugar can be processed by the liver. That's... even more hair-splitting than I remembered it to be!

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