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That is not information conveyed in the article you linked. The primary protection is against Y. Pestis, I went to the trouble of looking and I find no evidence of significant protection from other pathogens, at least for the ERAP2 variant in question.
As the article confirms:
Yeah. It's a tradeoff. What would you rather have, a genetic resistance to Y. Pestis that is far from perfect, and obsolete with the age of antibiotics, or elevated risk of Crohn's disease, which is chronic and lifelong?
They were doing just fine before being exposed to alien pathogens. And the Europeans probably picked up syphilis in the process. I don't see how this improved things for anyone.
That is much more likely to be a consequence of improved nutrition and sanitation. The wealthy also had the luxury of flight in the face of the plague. They also, yes, probably have better genes for physical and mental health overall, but probably not to that drastic an extent.
That's fine.
Yes, and you need to justify that assumption better. North African Berber populations are not the same as the people further south, the Sahara Desert is remarkably inconvenient. There has been a great deal of population admixture over 1.5 thousand years, so a naive extrapolation from current IQ figures is fraught.
It is a very good thing we have options these days, like gene therapy as I've mentioned previously. We do not need war and disease to trim the herd, it's a horribly crude solution at best.
Even in the absence of civilizational collapse, selection pressures were still present. In the absence of modern medicine, disease was rampant. Wars still killed people, albeit at a lower background rate. I wouldn't accept the trade of setting back living standards and tech levels so hard it took a thousand years to recover, during the late Enlightenment or early Industrial Revolution.
The question is what would I have preferred my ancestor to have had who was actually living in that time and place? Obviously I'm still here, meaning all my ancestors survived all that war and disease to reproduce. If they did not have that variant there's a higher likelihood I am not here.
They were doing just fine until.... they met other people. That's a great evolutionary strategy. They didn't have to survive those apocalyptic diseases like Europeans did, and they melted on first contact with the outside world.
Yes they did, and I am saying that was a selection pressure, as ugly as it is to say. The overall quality of the survivors is higher than the population before the event. That is the definition of eugenic.
I feel like you are refusing to understand what I am trying to say. I am not trying to say "war and apocalyptic diseases are good options today to improve society." I'm saying very real selection effects from these high-mortality events lend credence to the "hard times create strong men" meme and "good times create weak men" adage, but do not guarantee that a people living in a miserable situation will always become better for it. "Hard times" are often, but not always, associated with major historical genetic changes. In the case with Rome the genetic changes follow the cycle well from end-to-end: Latin tribal upstarts raise hell on the Italian peninsula, create strong imperial genetic stock and Civilization. Civilizational success leads to decadence: importing slaves from all over the world, population replacement, decay of Noble status and lineage. Decadence creates stagnation and decline. Decline creates a genetic cleansing event that creates the modern European/Italian and progresses to the Middle Ages, where these cycles of pressure continue until we are here today.
I understand what you're trying to say. I've noted the points of agreement and disagreement. The most specific is the claim that the change in population after the collapse of Rome was dysgenic, and that the specific adaptation to the Plague was a net positive after the plague subsided. That might be true, but definitely needs more evidence to be more than a possibility. The selection pressure wasn't so high that the protective allele became predominant, and that's despite Bubonic plague being a recurring problem.
My gripe is with the claim made (by others) that the cultural consequences of "hard times" are positive on net. It is also true that selection pressure strong enough to overcome genetic drift will produce adaptations that might be eugenic, depending on the context. For example, the protection provided by the mutant ERPA2 is probably dysgenic now, since we don't really have to worry about the plague but can't cure Crohn's.
More importantly, the advocates for the Hard Times thesis often want to intentionally cause suffering and hardship, because they think that's good. Even if it's debatably eugenic, the juice is clearly not worth the squeeze.
I do not lightly agree with SecureSignals about anything, but I think he has a point that you'd misunderstood his claim: while it may be true that some advocates for the meme want to intentionally cause Hard Times, Signals had bee fairly clear that he wasn't making that point, merely the retrospective claim that historically, as a matter of fact, Hard Times have produced Strong Men via eugenics - whether or no that was "worth it" and whether or not that would or should still work today.
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You have that backwards.
Latin warlords conquer Italian Peninsula: "Hard Times" that create good men (From frame A towards B, essentially genetic replacement of Early European Farmers with Indo European colonizers).
Genetic Changes during Imperial Rome: "Good times" that create weak men (From From B to Frame C). Decadence, dysgenic cultural practices enabled by prosperity: fertility decline, population replacement, decay of noble status and lineage. Huge genetic shift in the population.
Late Antiquity: "Weak mean create hard times" - From Frame C to D and onwards, imperial Rome collapsing and being genetically cleansed by the barbarians.
Medieval and Early Modern: "Hard times create good men": Genetic changes from Imperial Rome are reversed, genetic foundation for the next phases of European culture.
I apologize. I misread:
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