site banner
greyenlightenment  investments: META/FBL, TSLA, TQQQ, TECL, MSFT ...  11mo ago (npr.org)   2339 thread views

Eli Lilly releases data for a new weight-loss drug to tackle obesity : Shots - Health News : NPR

npr.org

This drug is a true gamechanger

In the SURMOUNT-1 study, people who took the highest dose of tirzepatide, most of whom had a BMI of about 30 or higher but did not have diabetes, lost about 21% of their body weight during the 72 week study. As researchers point out, for people who have bariatric surgery, typical weight loss is about 25% to 30% of their weight, one or two years after the surgery. In the tirzepatide study, 36% of people taking the highest dose lost 25% or more of their body weight.

this is comparable to bariatric surgery

11
Top Bottom Old Controversial Comments
Jump in the discussion.

No email address required.

This is what I was afraid of. As more evidence mounts that the obesity epidemic is caused by something environmental (either a change in dietary composition or a toxin of some sort), a "cure" has arrived just before the root cause has been proven. Instead of targeting the root cause and removing whatever is causing obesity from the environment, slimness will now be sold to those who can afford it. I think even if researchers identified the cause of obesity, there would be a lot of incentive to keep the obesity train rolling, to everyone's detriment.

And obesity is just the most visible symptom of metabolic disease. Could we still be at increased risk of cancer, heart disease, etc even with these miracle drugs?

In any event, someone's paying for them. It's a huge inefficiency. We're paying somewhere for food or a toxin that makes us metabolically diseased, then paying someone else for a drug to get rid of one of the symptoms. Besides that, obesity is becoming a problem even in poorer countries, countries where the government cannot afford to pay for medication for each of their citizens.

It also worries me from a health perspective that we are treating it as an overeating problem, and solving it by making people less hungry, instead of addressing the fact that our basal metabolic rate has decreased a significant amount in the past century.

Can the decline in BEE be explained by us just being unfit skinnyfats?

They say that it has been adjusted for body composition and age. Also, look at this comparison. Female athletes in 1986 had a lower BEE than the average woman in 1919.

What is this place?

This website is a place for people who want to move past shady thinking and test their ideas in a court of people who don't all share the same biases. Our goal is to optimize for light, not heat; this is a group effort, and all commentators are asked to do their part.

The weekly Culture War threads host the most controversial topics and are the most visible aspect of The Motte. However, many other topics are appropriate here. We encourage people to post anything related to science, politics, or philosophy; if in doubt, post!

Check out The Vault for an archive of old quality posts. You are encouraged to crosspost these elsewhere.


Why are you called The Motte?

A motte is a stone keep on a raised earthwork common in early medieval fortifications. More pertinently, it's an element in a rhetorical move called a "Motte-and-Bailey", originally identified by philosopher Nicholas Shackel. It describes the tendency in discourse for people to move from a controversial but high value claim to a defensible but less exciting one upon any resistance to the former. He likens this to the medieval fortification, where a desirable land (the bailey) is abandoned when in danger for the more easily defended motte. In Shackel's words, "The Motte represents the defensible but undesired propositions to which one retreats when hard pressed."

On The Motte, always attempt to remain inside your defensible territory, even if you are not being pressed.


New post guidelines

If you're posting something that isn't related to the culture war, we encourage you to post a thread for it. A submission statement is highly appreciated, but isn't necessary for text posts or links to largely-text posts such as blogs or news articles; if we're unsure of the value of your post, we might remove it until you add a submission statement. A submission statement is required for non-text sources (videos, podcasts, images).

Culture war posts go in the culture war thread; all links must either include a submission statement or significant commentary. Bare links without those will be removed.

If in doubt, please post it!


Rules


Recommended Posts And Communities

Recommended Realtime Chats