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Eli Lilly releases data for a new weight-loss drug to tackle obesity : Shots - Health News : NPR

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This drug is a true gamechanger

In the SURMOUNT-1 study, people who took the highest dose of tirzepatide, most of whom had a BMI of about 30 or higher but did not have diabetes, lost about 21% of their body weight during the 72 week study. As researchers point out, for people who have bariatric surgery, typical weight loss is about 25% to 30% of their weight, one or two years after the surgery. In the tirzepatide study, 36% of people taking the highest dose lost 25% or more of their body weight.

this is comparable to bariatric surgery

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Neither of those is a particularly good comparison. Down Syndrome is not something you can "fix" anyway, there's never going to be a miracle drug for it. Type 2 diabetes is not immediately visible (conditions like obesity that are visible make it more likely, but being obese does not guarantee you have diabetes and having diabetes does not necessarily mean you are obese).

What I mean here is that I suspect that simply having more obese people all around us has made us more tolerant of obesity in general (personally or in others) than we would be otherwise, or society would have been some decades past when obesity was less common, and having actually effective weight loss drugs available would then mean less obese people around us and the pre-00s greater-than-current disdain for obese persons returning.

I don't think this will change anything. Trans people, for example, are just 1% of population yet trans rights/inclusion has exploded