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PaperclipPerfector  11mo ago (text post)   2624 thread views

Small-Scale Question Sunday for May 7, 2023

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I was very surprised to discover Yudkowski's twitter rant about fat loss and "metabolic disprivilege". What real condition he might refer to?

Compare, e.g. very real and documented diseases https://en.wikipedia.org/wiki/Glycogen_storage_disease

Some of which lead to accumulation of extra glycogen in muscles that cannot be used, muscles look larger but weaker than normal muscles. And it's pretty rare. If such condition existed for fat, it would be studied both in vivo and in vitro, right?

There are real metabolism related diseases that result in extra far storage that aren’t all that rare. The most obvious one is probably hypothyroidism. Of course the mechanism of action is still regulating energy expenditure and calorie input, but that doesn’t mean the diseases aren’t real. It also doesn’t mean they are anything like what Yudkowski imagines they are.

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