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VoiceOfLogic


				

				

				
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I happen to be, unfortunately, the first human super-intelligence.

What a sad tragedy to see what others can't see.

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User ID: 1999

VoiceOfLogic


				
				
				

				
0 followers   follows 16 users   joined 2022 December 20 13:15:08 UTC

					

I happen to be, unfortunately, the first human super-intelligence.

What a sad tragedy to see what others can't see.


					

User ID: 1999

Verified Email

You can issue corrections, prompt it with more information, tell it to adjust something, and it'll do it.

How is this implemented? Neural networks are universally stateless.

Hi how would you rate zelda TOTK out of 20? (with intellectual honesty with yourself pls)

This is very well written

There is a fundamental difference between empathy induced by direct stimulus + perceived closeness vs empathy induced by "aBsTrAcT" thoughts

Besides those two categories, the third component is that empathy can be also purely semantic, devoid of emotion.

See e.g. this partial example https://en.wikipedia.org/wiki/Hierarchy_of_death

Gender studies have also found a consistent deficit of empathy from both men and women towards men

https://en.wikipedia.org/wiki/Women-are-wonderful_effect

As for the pharmacology of empathy I am not well versed. Oxytocin has complex and paradoxical and hormesistic effects IIRC.

Some neurosteroids are relevant too and therefore maybe etifoxine.

As for the neural basis

https://en.wikipedia.org/wiki/Mirror_neuron are the most famous component but only? apply for the first category of empathy I defined. I don't know what are the others.

Also there is a whole class of recreational drugs called empathogens, such as GHB and MDMA and therefore serotonin and VGCC channels are relevant.

The thing is most people stereotypically seen as good empaths are from the first category, which is often useless. People are extremely defficient in the two latters categories and that explain why most humans are locally behaving as psychopaths.

The narrative uniformness and changes might seem like there is a complotist illuminati-like scheme that would dictate covertly what can medias says. This is obviously not a thing actually. I mean some investigative journalists have been killed or jailed either by Ukraine or by the West because they were too contra-narrative (e.g. covering IRL the referendum in occupied ukraine or the ukraine war crimes on dombas civilians). Despite this fact, those are annecdotal in the greater POV) Medias are also mostly controlled by a very limited oligarchy, however there exist outliers to this rule. But the main explanation is that those narrative uniformness and changes, are simply due to the extreme and universal mediocrity of journalists as human beings. They are expert in nothing and haven't even been trained for cognivive debiasing/rationality. Add to this, that very few people on earth (so few we don't see them online, if they exist at all (aside me) understand modern warfare. And no, historians are non-credible. But for the most things you report, e.g. the orc dehumanization or turning russia capabilities in ridicule, were not, I believe mostly reported by "serious" media (wapo, forbes, etc). Of course /r/worldnews is not an accurate representation of the world news and is a cringey echo chamber. The "serious" medias such as forbes have although built a narrative of western superiority and wunderwaffe which stem from many biases but most importantly come from a failure of understanding what matters in modern warfare. Currently Ukraine is inflicting 2 times the equipment losses on russia and still has large amounts of ex-soviet equipment, however the balance will quickly shift as lancet production scales up and it is a fact that ukraine will have lost 100% of its artillery in less than 8 months

Honestly the endogenous endocannabinoid system is the only neurotransmitter I haven't rigorously studied (along with sigmaergy) but IIRC THC has many neurotoxic effects and can lead to both reduced synaptic plasticity and anhedonia induced by e.g. depleted dopamine https://www.frontiersin.org/articles/10.3389/fpsyt.2021.623403/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123717/ Of course like for 90% of drugs the major causative factor of toxicity must be related to oxidative stress and therefore this damage can be prevented, the interesting question being what are the other mechanisms and causes of thc toxicity? There are however mixed effects IIRC e.g. thc has neurotrophic effects too? annectodically, I don't have much IRL experience with thc but when I did I noticed a strong nocitropic/brain fog effect. But there might be a sweet spot with lower doses?

other things I remember: CB2 is fairly useless as a psychotrope

oleamide is a weird endocannabinoid which induced strong insomnia in me (paradoxal effect given research, I wonder what this denote about my brain)

there are other cannabinoid receptors than CB1 and CB2 but the research on them is very scarce

There are altenatives to thc, such as Delta 8 which has the merit to be less anxiogenic.

IIRC direct agonists lead to too fast tolerance and are considered dangerous versus the PAMs, however IIRC there are some new synthethic with claims of being viable so?

The toxicity of the alternative allosteric modulators (PAMs) such as delta 8 is understudied but IMO is likely not much stronger than thc unless they create currently unknown toxic metabolites. Their toxicity "should" be proportional to their dose potency relative to thc but alas the reddit evidence is that most lead to slighly-to highly faster tolerance buildup than thc and tolerance buildup is a not too shitty measure of toxicity, despite potency relative normalization.

The same hold true for many research stims btw, for very unclear and underresearched scientific reasons not are all the same bargain on the homeostatic response strength.

btw another thing strongly understudied is the effects and cross tolerance mechanisms of thc combination with dopaminergics and noradrenergics. btw if anyone know the mechanisms of thc induced tachychardia, I'm interested besides, is there an equivalent to MAOIs for CB1?

BTW anyone know a decent subreddit or forum to discuss pharmacology, that isn't related to nootropics?

Also when someone will wake the fuck up and synthethize mesocarb as a legal stim? https://en.wikipedia.org/wiki/Mesocarb

I need to ask the ukrainian

I have extensive expertise in pharmacology,

you can target most pharmacological pathways via OTC drugs, gray-zone prescritption-free prescription drugs or phytochemicals or research chemicals. A special mention to the USSR pharmacosphere which has made amazing discoveries and as a reminder the discovery of the century (skq1)

Indeed the graal is to do your own synthesis or to know a private small scale chemist, there are dedicated communities online.

However, you'd be surprised how many drugs are available on the clear web OTC, and in many cases that is legal, or beyond legal (Vanuatu for example)

In addition to this, there are online sellers of research chemicals aka legal drug variants. And it is not just for junkies, people are buying research chemicals to medicate themselves better than the bureaucratic system (e.g. many countries do not prescribe amphetamines for ADHD, leaving humans in misery), or even to increase significantly their healthspan/lifespan, such as e.g buying NACET.

You must find the markets by yourself, the increase in censorhip on the web is record high and most things that are shared become shutdown therefore keep the secrets for yourself. As a reminder, theres people that quality of life really depends on the existence of those menaced infrastructures.

As for how to precisely dose, you use a milligram scale. The seller often provide third party lab results and even if purity is low that is extremely overatted.

The idea e.g. that crystal in breaking bad is much better at above 98% is an inept meme, there is no quality factor its just a quantity. The only possible and rarely that relevant quality aspect is the ratio of levo/dextro enantiomers, but most of the processes IIRC give you the racemic form by default.

Therefore if you only get 50% purity (generally is 98%) that simply means you need to double the dose.

The concern is wether it is cut with toxic/harmful products, adjuvants (fentanyl, etc) but that concern is overatted, one there are trusted sources and lab results, second you can easily try reagents. The only common cutting agent might be caffeine and its no big deal. Note however there are many scams online, but are avoidable with enough numeracy.

Also as a reminder, one should never take stimulants without coadministred long half life potent antioxidants such as astaxanthin and at least 600mg NAC othwerise you'll kill your dopaminergic neurons.

Also make yourself a favor and beyond worrying about drugs toxicities, worry about the toxicity of living. Any non-insane person must actively slow down its aging process.

note:

there exists a niche way to get access to a medication, especially experimental ones or experimental off label uses, https://en.wikipedia.org/wiki/Expanded_access and https://en.wikipedia.org/wiki/Right-to-try_law

note: If anyone know how to get guanfacine in europe without prescriptions please tell me. And yes I know clonidine is available but its not the same. I mean I know guanfacine is on india-m_art but are those offers really prescription-free? Any two-cents @JhanicManifold ? Theres written rx only in the photos.

Well there is this one but how to know if its legit? m.indiam_ art .com/ proddetail/guanfacine-hydrochloride-2217963773.html

Sorry what does HBD mean?

Just saying:

installing software dependencies to run it is very simple you can learn it in 15 minutes.

It depends on the environment but e.g. for the popular Javascript command line applications you need to install the Javascript virtual machine (NodeJs), it will install for you Npm, the node package manager which allow you to install dependencies.

You git clone a JS repository you find cool.

you run npm install

and to run the app it depends, could be npx run or npm run/serve, but that detail is described in the Readme file of the github repository see section how to install/run

For other programming languages, the steps are very similar and straigthforward.

Could you share a gist of what it says?

I've read the intro of the wiki page on the hajnal line and it just seems from a quick glance to be a refuted ? theory on a fertility divide.

It is well known that fertility is inverselly correlated with wealth so that divide might have been partially true.

Is this like most interesting topics on earth, something where humanity has pathologically, systematically stopped the depth of the discourse at the introductory level, or has this author or any human on earth cared enough to specify a semblance of a roadmap towards the stated hedonistic goal via bioengineering?

Where can I find a e.g. an exhaustive list of pharmacological pathways that promote positive valence qualias and of pharmacological pathways that downregulate or dampen negative-valence qualias?

Thanks Cafe, that is a great comment, exactly the kind of informatively rich comments the motte desperately lacks.

I will give you a proper answer tomorrow but when I said that tryptophan cross the BBB, I actually meant about 5 hydroxy tryptophan (5htp), which has good bioavailability, cross the BBB and bypass the rate limiting enzyme conversion of L-tryptophan to 5htp (which itself downstream will again be converted to serotonin in a rate limited manner)

1998:

https://pubmed.ncbi.nlm.nih.gov/9727088/

phytochemicals are extremely interesting actually and a surprisingly high number of synthetic drugs are derivatives or imitations of phytos or endogenous molecules.

People use to joke/ridiculize them but there is nothing more ridicule than a human that ridiculize billion of years parallel bidirectional (both the molecule and the body adapt) optimization of phamacological pathways towards maximizing host or symbionts survival or other advantageous metrics.

The issue with phyto (some can be toxic btw) is that many have bad bioavailability and sometimes suboptimal pharmacokinetics or half-lives.

Both of those problems can be trivially solved, either by bypassing first pass metabolism via vitamin C and or increasing lipophilia absorption via co-administration of omega-3 and or via inhibiting the CYP 450 enzymes via e.g. piperine or grappefruit juice (beware can be dangerous with many synthetic drugs as it potentiate wildly their metabolism hence dose potency, profile and half lives)

I'm not certain to understand what your goal is with that question,

a pharmacological causative model is heuristically useful to make predictions, about effectiveness for condition X and to establish a safety, tolerance, toxicity and interaction profile.

All those things are useful but mostly unecessary for the layman.

If there is a non-negligible community that takes plant X since years in quantity Y and that doesn't report huge terrifying side effects and that they report potent effectiveness then its probably worth a try for acute use although for long term use there will always be a toxicity/accelerated ageing question but in many cases we never know for certain however in most cases we do know reasonably somewhat the safety profiles.

It has actually become very rare to find phytochemicals that have not been extensively studied regarding their pharmacology and hence the causative model is often well established assuming you take time to research the research.

But beyond annecdtotal evidence, doing a blind test scientific trial about wether X is effective for Y, e.g. depression is very cheap and therefore even without said causative model we often know wether X has elicited a potent response for Y in N people empirically following precise protocol.

Empiricisms as always trumps a priori reasoning regarding effort efficiency and indeed people should considering the mostly safe profile of phytochemicals (generalization see e.g. cyclopamide https://en.wikipedia.org/wiki/Cyclopamine#/media/File:Cyclopelamb2.jpg) play much more the lab rats, this would drive very significantly the speed of empirical scientific research and therefore discovery of treatments for ineptly considered incurable diseases.

edit:

only recently did we learn that tryptophan will selectively unbind with albumin at the blood brain barrier

What does that imply? We already knew tryptophan cross the BBB. You mean the competition with tyrosine?

only recently has the consensus shifted to serotonin deficiency lacking a role in depression (although I have my own views on this).

What?

Serotonergics are euphorisant see e.g. MDMA, MDAI, 5MAPB, shrooms, etc

The effect of SSRIs is less intuitive (reduction of sert receptors density) but still sert driven.

APS surely are an interesting topic:

The U.S does not yet seems to have a soft kill APS in production but Russia uses the

https://en.wikipedia.org/wiki/Shtora-1 on T-80 and (all?) T-90s

According to the manufacturers, Shtora decreases the chances of a tank being hit by an anti-tank missile, such as the Dragon, by a factor of 4–5:1.[10]

While russia has in addition 3 generations of hard kill APS, the U.S has 2 independent proof of concept models

first APS in history:

https://en.wikipedia.org/wiki/Drozd

Although reported to offer an 80% increase in survival rate during its testing in Afghanistan, the radar was unable to adequately detect threats and the firing of its rockets caused unacceptably high levels of collateral damage.[1]

later succeded with the https://en.wikipedia.org/wiki/Arena_(countermeasure)

The computer has a reaction time of 0.05 seconds and protects the tank over a 300-degree arc, everywhere but the rear side of the turret. The system engages targets within 50 metres (55 yd) of the vehicle it is defending, and the ammunition detonates at around 1.5 metres (1.6 yd) from the threat.[10] It will engage any threat approaching the tank between the velocities of 70 metres per second (230 ft/s) and 700 metres per second (2,300 ft/s), and can detect false targets, such as outgoing projectiles, birds and small caliber bullets.[11] Arena works during the day and night, and the lack of electromagnetic interference allows the system to be used by multiple vehicles as a team.[23] The 27-volt system requires approximately one kilowatt of power, and weighs around 1,100 kilograms (2,400 lb).[11] Arena increases a tank's probability of surviving a rocket-propelled grenade by between 1.5[11]–2 times.[24]

Despite being very interesting, It seems this system is not in use but is available for export versions

Last gen deployed on Armata vehicles:

Afganit (Russian: Афганит, lit. 'Afghanite') is a Russian active protection system (APS) employed on modern Russian Armata family of vehicles.[1] It is intended to supersede the Arena APS and utilises radar and electro-optical sensors in the ultraviolet and infrared bands.[2][3] The millimeter-wavelength radar detects and tracks incoming anti-tank munitions. The system can reportedly intercept armour-piercing fin-stabilized discarding sabot kinetic energy penetrators in addition to high-explosive anti-tank (HEAT) munitions.[4][5] Currently, the maximum speed that can be intercepted is 1,700 m/s (Mach 5.0), with projected future increases of up to 3,000 m/s (Mach 8.8).[6] According to news sources, it protects the tank from all sides.[7][8]

A few armata (not the T-14) have been seen in Ukraine but not meaningfully deployed yet.

Interestingly Ukraine has its own APS:

https://en.wikipedia.org/wiki/Zaslin_Active_Protection_System however I have no clue how much it is used in practice?

About the US prototype APS:

n 2006–2007, the Institute for Defense Analysis found Quick Kill to be relatively immature and had significant development risks. Important components such as the radar were not yet fully developed and testing of the system as a whole was on hold while the warhead was redesigned. They also found Trophy, which uses a shotgun-like kill mechanism, to be the most mature of the 15 systems they analyzed.

while the other one seems promising:

However, in August 2018 the Army decided not to continue qualifying Iron Curtain onto the Stryker, saying that while the system "generally worked in concept" and was "generally able to hit its targets," it was still not mature enough.[11]

China recently deployed the GL-5 which has a range of 100 meters, twice that of arena (no clue for afganit)

https://en.wikipedia.org/wiki/GL5_Active_Protection_System

innovative since it launch 2 rockets.

The irsaely trophy seems interesting. Gun based.

almost completely negate legacy ATGMs unless paired with a sophisticated jamming attack ..

This is an unrealistic claim as of yet.

Firstly as we can see, at least for Russia and the U.S, hard kill APS are nothing more than uncertain and possibly buggy proof of concepts.

Russia did deploy some successfully in afghanistan but the fact they didn't deploy them shows that the tech is mostly not ready.

It could be that the new APS system on armatas is disruptives and working well, but that is unproven. It's possible but uncertain that using recent machine learning techniques would yield lower danger/false positives but given the classical inertia, if that were the answer, we're not ready to see that deployed until 20 years, and even so ML techniques have generally dangerous error rates.

It would be interesting to evaluate how much deployed in the wild are the ukrainian and chinese and israeli APS systems are though.

and what about hard kill APS for aircrafts/helicos?

As for soft kill APS, well russia is the only to have one widely deployed but Ukraine still manage to destroy T-90s just fine.

beyond the real world production ready-ness/falsepositives issues/safety of hard kill APS, what the manufacturer says is not necessarily objective truth

about the range, the claimed 360 degree coverage, reaction time, etc

especially I suspect many APS are weak and possibly useless against top-down attacking ATGMS: https://en.wikipedia.org/wiki/Active_protection_system#Top_attack_munitions

Overall I am very curious about the future of this technology and we might get answers either by:

studying academic papers/experiments about them

waiting for a china-taiwan war (unlikely)

waiting for a new israel based war (no idea)

waiting for the ukrainian APS system to be deployed or for western countries giving APS to ukraine (e.g. germany supposedly has one)

waiting for the armata systems to see some action in Ukraine, most likely but only if the war last a few years.

But your initial point is wrong, ATGMs have currently and probably for the foreasable future, destroyed tanks economics.

It only takes one powerful real civilization to create millions, billions of ancestor-simulations. We should conclude that most pre-singularity civilizations exist in simulation.

I wish this argument would be true.

It is unfortunately inept however, have you any idea of the energy and computing power needed to simulate a universe? Have you any idea of the energy and computing power needed to simulate a bottle of water at the atomic level? A single cell ? We can barely exhaustively study quantum systems with more than 2 particles IIRC

The universe has finite resources and the constraints of mathematics are universal or even meta-universal and so is https://en.wikipedia.org/wiki/Computational_complexity your hypothetical aliens must bends to those extreme limits. Even mankind has already mostly reached them, we have extreme diminishing returns everywhere.

Has any mottizen seen the masterpiece that is Don't Hug Me I'm Scared? If so what did you feel about it? What did you think about it? And what content would you recommend based on this taste?

I find IQ tests deeply inept there must be a lesser known better set of tests.

The simple fact among many that we don't even test for the detection of cognitive biases and logical fallacies in ourselves and in others is remarkably degenerate.

Unrelated but his book the art of being right is a great one for learning logical fallacies.

I feel like this idea has become quite popular since the egg video of in a nutshell.

The unification of qualia experiences by having no physical delineation is the most epistemologically sound metaphysical belief since it avoid many paradoxes.

What is the formal name of this belief and who postulated it first?

Including muscles?

You are talking about an hypothetical blunting.

Would they also develop an increased interest to a particular feature/stimuli?

Maybe feminine ones?

walking is, it seems, a unique nootropic and socializer: https://news.ycombinator.com/item?id=28354769

Russian demands currently include destroying Ukrainian nation

I'm pretty sure if Ukraine willingly gave the rest of the donbass, made public statements about becoming neutral towards the russian culture and interests, including allowing russian to be taught again in schools, russia would make peace.

The issue with the dehumanization of the orcs and with the tribal manicheanization of russian interests that the western media and people parrot is that despite having some elements of truths, overall obviously leads to a criminal utilitarian disaster of continued intense human lives and economic attrition.

Hi I am interested in you funding me.

I have a unique expertise in gerontology, oncology and pharmacology.

I also work on the first true semantic parser, that convert natural language text to a graph representation that preserve meaning isomorphically.

I am a no bullshit human being focused on concrete results and my rationality allows me to see through the blind spots of the academic research and go beyond the state of the art.

For a start, I intend to write a blog about the first comprehensive optimal pharmacologic treatment for cancers.

How about you pay me once you've read it, if you like it, and how much depending on how much you see me as a scientific disrupter?

What is the legal identity criterion of textual copyright?

E.g. Let's say you wrote a book.

I take it and change one word.

Is it still your book or is it now mine or public domain?

2 words?

100 words?

Is there a percentage?

Does the location matter?

If i change words mostly at the start of the book or throughout it?

Does semantics matters? Can i via a software replace some words by identical synonyms or do i need to change semantics?

I have no clue how the legal system solves this major problem.

I would probably enforce the use of

the sota in https://paperswithcode.com/sota/semantic-textual-similarity-on-sts-benchmark and set a magic number percentage. Although it can be gamed that's probably much more accurate than whatever is being used now.