Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?
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Notes -
True to my word, I recently acquired oral semaglutide. I've been aware of the drug since initial weight loss trials, and the moment it was available, I got my diabetic and overweight mom to begin it. She had a rough start, the nausea and GI upset was unpleasant to say the least, but it settled down and she's fine now, probably lost 5kg. My current goal is to convince her to increase her dose from 7mg to the next step up, which is long overdue.
I gained about 5-6 kilos over about 4 months, both because of starting an antidepressant that increases appetite, and because a change in workplace made me far more sedentary.
This, alongside a recent breakup, jogged me into gear. I've begun working out, aiming for muscular hypertrophy rather than strength. No point being able to lift a boulder if you don't look it. However, the semaglutide works, and has drastically slashed my appetite. My body only wants about half what I'd normally eat, and I have to force myself to eat more despite feeling full.
My question is, to what extent can I achieve both significant weight loss as well as some muscle gain? Due to recent weight gain, I believe I could manage a mild to moderate caloric deficit (~10%) without overly compromising my gains, as long as I consume enough protein. To the more experienced gym goers here, does that sound correct? Any tips or tricks?
(I'll buy some creatine soon enough, stuff works)
Exercise.
That's it.
Both I and my brother are on semaglutide, and we're both consistently working out, and I've not noticed any loss in muscle mass.
If anything, I now have much more energy, allowing myself to push harder and faster, but that's just with me.
Just out of curiosity, is there any reason you choose oral over injection?
Thank you. Glad to hear from someone in the same boat.
Oral over injection? No particular reason. I wouldn't say that I'm so averse to needles that I couldn't dose myself up. But all else being equal, I'd prefer the pill.
This question prompted me to actually check the difference in price. And it's a large one. 7mg oral sets me back $100/m, even the lowest (0.5mg) dose of the injectable pen, Ozempic, would be closer to $500/m.
I see no real advantage in the injections when they're priced that steeply. You need a higher dose orally, but that's not reflected in the pricing.
I was curious if there was something I'm missing, hence my question.
Granted, we're in completely different locales, so pricing is likely rather different; for me, injections of Semaglutide come at around 200$ a month(tax included).
And I won't even go into the recent scam prices they're now charging for Ozempic.
Supposedly, you can get Semaglutide even cheaper than my pricing from the same outlets pharmacies get it, as long as you're not afraid of doing a little mixing on your lonesome. I may go that route, once my prescription runs out.
If you haven't read it already, Scott's "Semaglutide: More than you wanted to know" series does a deep dive on alternative sources. If I had been priced out of branded tablets, that's what I'd have gone for. Even then, I'm a little unsure of the legal particulars in both India and the UK, his post was for American audiences.
I am convinced, however, that that route is safe enough. It's really not that hard to reconstitute the powder in bacteriostatic water and manage a s/c injection.
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