The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:
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Requests for advice and / or encouragement. On basically any topic and for any scale of problem.
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Updates to let us know how you are doing. This provides valuable feedback on past advice / encouragement and will hopefully make people feel a little more motivated to follow through. If you want to be reminded to post your update, see the post titled 'update reminders', below.
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Advice. This can be in response to a request for advice or just something that you think could be generally useful for many people here.
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Encouragement. Probably best directed at specific users, but if you feel like just encouraging people in general I don't think anyone is going to object. I don't think I really need to say this, but just to be clear; encouragement should have a generally positive tone and not shame people (if people feel that shame might be an effective tool for motivating people, please discuss this so we can form a group consensus on how to use it rather than just trying it).
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Two new monoclonal antibodies are being trialed by Regeneron: trevogrumab and garetosmab. Both are skeletal muscle growth factors, counteracting myostatin and activin-A.
When used together with semaglutide, they worked really well in monkeys: not only did the monkeys lose fat, but they also actually gained muscle. Limited human trials are not as promising (no one gained muscle mass just by dieting and two people died, but the causes might be unrelated), but still good: instead of losing half as much muscle mass as you lose fat when taking semaglutide, the group receiving all three drugs lost only one tenth. And they lost ten extra pounds of fat, too!
Does this mean everyone rich enough to afford this cocktail will be not just lean, but shredded in a few years? It's looking this way.
Does it write on their face that they have taken semaglutide or not? if it fixes ozempic face it will be very successful.
Isn't Ozempic-face just an effect of rapid weight loss, rather than something specific to the GLP-1 agonists?
Seems like the solution there is just to take a lower dose and lose the weight less quickly. Maybe take collagen supplements.
Yes, the face is one of the body parts that loses weight the quickest, so when you have a massive caloric deficit on semaglutide, your face grows gaunt faster than the rest of the body. That, and people are attuned to small facial differences, so going from a typical plump American face to a one that is actually able to contract and show facial lines is striking.
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