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Culture War Roundup for the week of June 23, 2025

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Recently on LessWrong: Estrogen: A trip report

(Yes, he's treating estrogen HRT as the type of psychedelic drug that might necessitate a "trip report".)

There's a lot to sift through here, but the most interesting part of the post to me was being introduced to the concept of the schizotypy spectrum, a related-but-distinct counterpart to the autism spectrum. Autistic traits and schizotypal traits both have similar outward manifestations (e.g. introversion and difficulties with social interaction), but they have different root causes and different internal subjective manifestations (principally, autistic types are higher in detail-orientation, and schizotypes are more prone to disorganized and delusional thinking):

A couple of years ago Ely recommended that I read the paper, Autistic-Like Traits and Positive Schizotypy as Diametric Specializations of the Predictive Mind (Andersen, 2022). It turned out to be the most interesting paper I read while writing this post. The author proposes that the archetypal behavioural traits observed in autism and schizotypy – like variation in attentional modulation, theory of mind, and exploratory behaviour – are downstream from a fundamental oversensitivity or undersensitivity to sensory prediction errors, respectively:

It has previously been argued that autism-spectrum conditions can be understood as resulting from a predictive-processing mechanism in which an inflexibly high weight is given to sensory-prediction errors that results in overfitting their predictive models to the world. Deficits in executive functioning, theory of mind, and central coherence are all argued to flow naturally from this core underlying mechanism.

The diametric model of autism and psychosis suggests a simple extension of this hypothesis. If people on the autism spectrum give an inflexibly high weight to sensory input, could it be that people with a predisposition to psychosis (i.e., people high in positive schizotypy) give an inflexibly low weight to sensory input?

[...]According to these models, everyone falls somewhere on the autism–schizotypy continuum, and neither autistic-like traits nor positive schizotypy represent dysfunction. Instead, each side of the continuum is accompanied by its own set of cognitive-perceptual strengths and weaknesses. People high in autistic-like traits are detail-oriented, have a focused attentional style that allows them to ignore distractors, have some advantages in sensory-discrimination abilities, and have highly developed systemizing skills, allowing them to learn and use complicated rules-based systems.

People high in positive schizotypy tend to be imaginative and creative and have a more diffuse attentional style (compared with the average person) that allows them to switch their attention more easily. There is also some evidence that people high in positive schizotypy tend to direct their attention toward highly abstract, "big-picture" concerns rather than focusing on details.

[...]Although the autistic type may rely more on culturally inherited high-level belief systems, the schizotype's proclivity for tinkering with high-level priors may lead to the construction of relatively idiosyncratic high-level belief systems. In our own culture, this could manifest as having odd or (seemingly) unlikely beliefs about high-level causes. This may include beliefs in the paranormal, idiosyncratic religious beliefs (e.g., being "spiritual but not religious"), or believing conspiracy theories, all of which are associated with positive schizotypy.

The author of the post then goes on to claim that, subjectively, estrogen caused him to experience a shift away from autistic traits and towards schizotypal traits:

I'll outline some of the psychological changes I've noticed in myself since starting estrogen. The term "schizo" is used very informally in today's internet vernacular, making it difficult to discuss these concepts in a sensible manner – but if the reader is comfortable playing armchair psychologist, perhaps they can judge for themselves whether the following makes me more "schizo":

  • Increased predisposition towards associative thinking. Activities like tarot are more appealing.
  • Increased predisposition towards magical thinking, leading to some idiosyncratic worldviews. This can probably be gauged by the nonsense I post on Twitter.
  • Increased experience of meaningness in day-to-day life. This felt really good.
  • Increased mentalising of other people's internal states, resulting in a mixture of higher empathy and higher social anxiety. I'm somewhat more neurotic about potential threats.
  • Decreased sensory sensitivity.
  • Decreased attentional diffusion, contrary to what the paper predicts.
  • Decreased systematising and attention to detail, for instance with tedious matters like finances.

Obviously this all has to be taken with a grain of salt, because the risk of confounding factors and psychosomatic/placebo effects in this case is high. Nonetheless, I'm curious whether pre-existing schizotypal traits in an individual (contrary to the author's experience in which HRT induced these traits) might play a causal role in explaining the abnormally high incidence rate of MTF transsexuality among so-called "terminally online" young men. By "terminally online" I mean the prototypical image of this demographic: likely to be in a STEM field, likely to have had little romantic success with women, likely to have obsessive "nerdy" interests like anime and video games, etc. This demographic is often stereotyped as "autistic", although that label may potentially conflict with the fact that MTF transsexuals are disproportionately drawn from this demographic as well, since it's not clear a priori why a disorder that allegedly gives you a "hyper male brain" would also make you more likely to want to be a woman. But if some of these "autistic" men actually belong to other personality clusters that have a tendency to masquerade as autism, it could help us build a higher resolution mapping of this region of cognitive space and provide more accurate explanations of the trajectories of different individuals (especially because one of the schizotypal traits is, as mentioned previously, a predisposition towards delusional thinking).

Regardless of which theory ultimately turns out to be correct, I think the biological basis of LGBT traits (or at least, which intrinsic traits increase one's predisposition towards being LGBT) is a subject that deserves further study. In my experience, anti-wokes are more likely to entertain the possibility of race and sex differences being biologically intrinsic, but they shy away from applying biological explanations to LGBT, preferring instead to endorse social constructivist theories (and in particular, the "social contagion" theory for transsexuality). Wokes are the opposite, heavily opposing biological explanations for race and sex differences but somewhat warmer towards biological explanations for LGBT (although they may not allow themselves to present it in exactly those terms). I prefer the simple, consistent position: it's all (at least partially) biological! Social contagion is undoubtedly a part of why the incidence rate of transsexuality has skyrocketed in the last several decades, although I think it's clear that only some people are susceptible to "catching" the contagion in the first place, and one's individual susceptibility is biologically mediated.

Do these people want to make me actively hate 'trans' people? I mean, I have some difficulties with how some strands of activism are playing out (particularly the rigid reinforcement of simplistic gender roles of the 'blue is for boys, pink is for girls' type) but I don't think I hate anyone.

And then I read shit like this and I want to get a gun and start shooting (in Minecraft).

"Ooh, I tried oestrogen and it made me so girly! I liked tarot and magical stuff and giggling and being all fuzzy brained!"

(And I say this as someone who likes playing around with tarot imagery but don't treat it as serious.)

I have been on oestrogen all my life (up to menopause) and if it made me describe my sensations like this, I would have preferred to jump off a cliff. "Oh gee, the reason I can't maths is because my little girl brain so soaked in hormones, gosh!"

I think there's a lot of "I expect X to be the opposite of Y, and if taking A gives me the sensations of X, then I will behave differently to how I normally behave" going on here. I think there may well be some physical changes, but mucking around like this is just annoying as all hell.

"According to these models, everyone falls somewhere on the autism–schizotypy continuum"

Yeah, and what makes these models worth more than a hole in the ground? "Hey, by our new model, everyone is some flavour of crazy and if you're not Stereotypically Male Brain Things oriented then you must be Stereotypically Female Brain People oriented".

Give me a break. Or a bottle of sherry. I feel the glittery pink girly need to get blind stinkin' drunk after being exposed to this.

EDIT: On a more serious note, why doesn't progesterone get any love? In cis females, oestrogen isn't there on its own. There's a balance between the two (and more). Do trans women/trans experimenters like our guy here ever dose themselves with progesterone as well to get the full female experience?

Oh, I see he did:

Additionally, at one point I tried taking a 300 mg progesterone suppository. This made me feel quite stupid the following day, so I did not try this again.

Passing a remark about "well duh you stuck a progesterone suppository up yourself all in the name of amateur hour endocrinology, I don't think it was the progesterone that made you stupid" would be too easy - oh darn, there I went and did it. But yeah: wanting the alleged results of oestrogen without figuring out the natural cycle of the cis female hormone levels does lead me to think that there's a lot of "I expect to feel like a, b and c, and I'm going to feel like that even if I have to imagine it!" going on here, I don't think there's a neutral/blind "let's see what happens" trial happening here.

EDIT EDIT: Clearly I'm coming at this from the angle of someone who naturally had these hormones all my life, so I can't speak as to what it would be like to experience the effects for the first time. But I have to say, all the "it's like being on mild psychedelics" - I've never tried psychedelics so I can't say if being female is like being slightly stoned all the time, but the rest of it - cutting down sensory issues, helping with sleep, etc.

Oh how I wish. I've had mild insomnia all my life, and the good old autism spectrum "this tag on the collar of my clothing will drive me insane if I can't tear it off right now" sensory issues. Oestrogen is not a magic cure for that, folks, so I strongly suspect some placebo effect going on, as well as the guy admitting he's doing/had been doing a lot of ketamine at the same time.

(And I say this as someone who likes playing around with tarot imagery but don't treat it as serious.)

In the hope of trying to find something more positive to talk about -

I wonder if there are any other Motters with a passing interest in tarot? I used to be fascinated by it as well. I give no credence whatsoever to divination, but I think the imagery of the tarot is extraordinarily rich and multi-faceted. Its supposed divinatory powers, I hazard, have more to do with the way that that imagery is both endlessly open to interpretation and psychologically provocative. If you find yourself mentally 'stuck', a randomised pile of images from the tarot may well give you the jolt you need to consider new perspectives.

I don't use it for advice myself, but I can still appreciate the symbolic language it provides. If there are any other Motters familiar with it, maybe it's worth a chat in the Fun Thread one day?

Clearly I'm coming at this from the angle of someone who naturally had these hormones all my life, so I can't speak as to what it would be like to experience the effects for the first time.

This has always fascinated me when I read accounts by trans men. Their description of what testosterone does to their mental processes sounds completely alien to me. I cannot relate to it whatsoever. There are a number of possible explanations for that, one of which is, indeed, that I've had this level of testosterone all my life, and my body is accustomed to it. It's just part of the way I think, and any downsides or difficulties that come with it are things that I have had decades of practice compensating for. Someone who suddenly shifted from a much lower level of testosterone to the level of a natal male like me, however, probably would experience it as an overwhelming flood, and that might explain, for instance, them having problems with impulse control that I have never had.

If so I can only guess that it's plausible that a natal male suddenly taking a much higher dose of estrogen would experience a similar shock, but in the other direction, and that it would be something that natal women cannot relate to either.

Of course, as the top-level poster mentioned, it also seems likely that there's some element of placebo as well. If you're telling yourself that you're taking a chemical that's going to make your more feminine or girly, well, you can probably just think yourself into that absent any chemical effects at all. All the more so if you're also making intentional behavioural or social changes. So plenty of grains of salt seem warranted here.

This has always fascinated me when I read accounts by trans men. Their description of what testosterone does to their mental processes sounds completely alien to me. I cannot relate to it whatsoever.

I've found at least some of their accounts to be startlingly accurate, and quite revealing.

I was once reading a book -- can't at all remember the name now -- written by an FTM transsexual describing her experience with testosterone. She was older and she would have been going through this before the internet (and before free 24/7 porn, keep that in mind).

One of the effects she described was how her visual perception seemed to become "more 3D" (lines up with how men tend to do better on spatial rotation tasks), especially whenever she looked at women or images of women. A billboard showing a sexy woman suddenly "popped" for her in a way that it never had before which consequently made it much more attention-grabbing, despite the fact that she had always been a lesbian even prior to starting testosterone. She was still subjectively viewing women in a new way, which is exactly the sort of effect I would expect testosterone to induce.

She described an episode where she went with some female friends (all of them lesbian or bisexual) to watch a series of film screenings at an indie theater. One of them was a short reel that showed various women in bikinis and underwear doing things like dancing, striking sexy poses, maybe a bit of a striptease, things like that. And all of her friends were laughing at it: like, oh look at these girls being so silly, haha. But she couldn't help but be struck by how serious the images seemed to her. She looked at her friends laughing and thought, "why are you laughing? This isn't a joke. Stop laughing." And I just thought... yes, this is it! This is the difference between male and female sexuality! You couldn't ask for a more perfect illustration, it's amazing.

Kind of frightening to think that one little chemical can unlock such complex emotional states. But, there you have it.

She looked at her friends laughing and thought, "why are you laughing? This isn't a joke. Stop laughing." And I just thought... yes, this is it! This is the difference between male and female sexuality! You couldn't ask for a more perfect illustration, it's amazing.

I fully believe that this is the testosterone experience, because it matches observed behaviors. But I've always wondered how people on testosterone from birth reconcile that hormone-induced aura of intense seriousness and urgency around whatever their sexual desire of the moment is, with the fact that if you look at it objectively the sexual impulse is pretty ridiculous.

Like, rub your penis on her foot. Rub it. On her foot. Or on that corpse. Go on, DO IT. Rub your penis on that unconscious person. Rub your penis on that toddler. Look at that girl's nipple. It's very important that you look at it! Go on, make visual contact with the external part of our mammalian glands designed for feeding young. You need to see it! You do! Look at it!

In service to this feeling of seriousness, men have betrayed their friends, their families, their country, they've lied, stolen, squandered fortunes, murdered and courted their own deaths because it was so deadly important to rub their penis against this specific thing in this specific way. I mean, I totally get why the evolutionary programming would exist, and ours isn't even that extreme in a world where some spiders' mating instincts get them slowly eaten alive. It just seems as though it would be weird to be a self-aware, reasoning person who's nonetheless in the grip of that kind of perceptual distortion. Women also do dumb things for biology, and women also have plenty of our own weird animal instincts, but for the most part we don't have anything quite so trippy as "this specific flap of somebody else's flesh is now the literal most important thing in the whole world."

It just seems as though it would be weird to be a self-aware, reasoning person who's nonetheless in the grip of that kind of perceptual distortion.

It's a good question!

All humans are familiar with the experience of impulse control, and the failure thereof. You should start that project tonight, but you don't. You shouldn't eat that donut because you're on a diet, but you do. You know that rationally you should be able to control your impulse, and it would be better for you if you did, but that often doesn't help much in the moment. These are universal experiences. The only difference with men is that they experience particularly strong sexual impulses, of a variety which many women find foreign. Like many impulses, they're fundamentally immune to examination by reason (knowing that the donut is unhealthy for you doesn't stop it from tasting good).

Impulse control follows a bell curve. Most men are able to rein in their sexual impulses and live perfectly normal lives in accordance with social expectations. The ones who are cursed with a sufficiently deleterious combination of high impulse intensity / poor impulse control are the ones who become criminals.

The fundamental point you're gesturing at is correct: men are insane! Their insanity has been the engine of so much death and destruction throughout history. But it's also been the engine of so much beauty and goodness. Things in life have a habit of working out like that.

Like many impulses, they're fundamentally immune to examination by reason (knowing that the donut is unhealthy for you doesn't stop it from tasting good).

Impulse control follows a bell curve. Most men are able to rein in their sexual impulses and live perfectly normal lives in accordance with social expectations.

The everyday impulse/akrasia thing you're describing matches female sexuality just fine, I think: certainly pure horniness does impel women sometimes to make choices they later regret. But I quoted your passage upthread, re: male sexual desire conferring an aura of importance and seriousness on its object, because that seems interestingly different. Normal appetitive impulses like eating junk food are hard not to act on, but they don't really involve a sense that "this is serious, this is not a joke," do they? I've gobbled a donut in a weak moment, but I would never say that the donut felt serious at the time, nor would I be annoyed if somebody joked about eating. In fact, I was very aware of the ridiculousness of it, even as I was eating. If somebody offered me donuts in exchange for state secrets, no part of me would think it was the right thing to do. I don't think I would have willingly hurt someone to get at the donuts. If somebody took the donuts away mid-binge, I would be relieved; I wouldn't have laid deep plots to get some more.

Whereas, the passage you quoted seems to be getting at a kind of a weird transvaluation-of-values field that testosterone creates around the object of desire, where whatever the penis wants seems worthwhile and important in itself: not just having a moment of weakness and regretting it, but having one's whole will redirected, such that old values or priorities just aren't relevant anymore. That's probably a stretch based on just the one statement in your comment, but I can think of various other examples that this makes sense of. I've heard people remark on the cold, unapologetic demeanor of men who have midlife-crisis affairs or come out as gay, etc.: maybe they cared about their wife and kids before, but now absolutely nothing feels as important as pursuing that hot secretary or that succession of Grindr hookups, whatever. Fetishists have laid incredibly complex, years-long plans in starry-eyed pursuit of goals that violate basic self-preservation logic, like freezing off their hands to replace them with paws or recruiting another man who will cut off, fry and eat their own balls. That value-revision power gets deployed for good in the whole manic pixie dream girl trope, where just the experience of sexually desiring a fetishized girl (usually a cypher, not a person: normally the guy lusts at first sight after noticing her 1-2 incredibly attractive physical features) supposedly revitalizes the hero's whole life, changes his priorities and makes him a permanently better man.

I obviously have no firsthand experience of male sexuality, but sexual desire that can change your sense of what's important, your affections, and your character, making you permanently callous to loved ones or calmly indifferent to the loss of your limbs, feels qualitatively different from donut-binge genital impulses. The only other thing I know of with that eerie character-rewriting effect is substance addiction.

The fundamental point you're gesturing at is correct: men are insane!

I'm absolutely not saying that men are crazy, because I don't know what it would mean to be "sane" at the level of basic motivational wiring. It just is what it is. Obviously the process can work for good if young men lust after wholesome people in wholesome ways. I was just saying that it would feel very strange to have a constantly-on hormonal system that could fully rewrite one's conscious sense of reality itself like that, because aside from having a baby, I don't know of any female hormonal dynamics that can accomplish anything similar. But I'd also be curious if this resonates, if testosterone-based sexual desire feels to most men as it does to the hand-freezing-off guy, or if there's something fundamentally missing from my outsider's impressions of how the whole thing works.