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Wellness Wednesday for January 4, 2023

The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:

  • Requests for advice and / or encouragement. On basically any topic and for any scale of problem.

  • Updates to let us know how you are doing. This provides valuable feedback on past advice / encouragement and will hopefully make people feel a little more motivated to follow through. If you want to be reminded to post your update, see the post titled 'update reminders', below.

  • Advice. This can be in response to a request for advice or just something that you think could be generally useful for many people here.

  • Encouragement. Probably best directed at specific users, but if you feel like just encouraging people in general I don't think anyone is going to object. I don't think I really need to say this, but just to be clear; encouragement should have a generally positive tone and not shame people (if people feel that shame might be an effective tool for motivating people, please discuss this so we can form a group consensus on how to use it rather than just trying it).

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Is it best to have antioxidant foods with inflammatory foods that you already eat (grains/meat), versus on their own? Eg, black tea and ginger with red meat, versus black tea and ginger in the morning and red meat at night?

Given "meat" was a human dietary staple for a million years, and "grain" has been a dietary staple for (some for) 100k, both have dozens of useful dietary components with complex effects, and "inflammatory" in this context means "some response to harmful stimuli", and the scientific backing for their inflammation being, variously, observational diet-survey studies and questionable in vitro experiments - the claim that "meat and grain are inflammatory" isn't very useful.

Similarly, the claimed antioxidants in black tea and ginger also coexist with dozens of other compounds (although not useful ones), their antioxidant efficacy was demonstrated in in vitro studies with little relevance to human consumption (as distribution and metabolism significantly affects those compounds), said antioxidant effect has no proven relationship to whatever the claimed inflammatory mechanism of grain or meat was, and even if those antioxidants were effective, they'd be much less efficient at preventing oxidative damage than the evolved biological mechanisms for doing so - like catalase, glutathione, superoxide dismutase - complex, finely tuned proteins, as well as others.

So - evening, naturally.

So, the grains in common use 20k years ago are not the same as today. Most common grains eaten today are inflammatory, causing oxidative stress.

Ancient humans ate a variety of fibers and plant matter consistently, which we do not. They may very well have combined natural anti-inflammatory herbs etc with large meals. Garlic and meat is a good example. Your comment is not useful to my question. Antioxidants from green tea and cocoa are healthy, and my question is whether the combination of these healthy natural “fighters” of oxidative stress with exogenous anti-inflammatory compounds is good for health.

I suppose, on revisiting my question, it’s a good idea to combine inflammatory food with anti-inflammatory plants as this is how most ancient societies cooked

The idea of doing an opposite mechanism to fight a given toxicity is trivial and indeed a good one in theory.

People have a fuzzy understanding when they talk about inflammation though.

One would be symptoms of exogenous toxicity such as indeed oxidative stress. But that is not per se what inflammation denote, it denotes an autoimmune toxic but potentially useful reaction, mostly mediated via some Interleukins, TNF and IFN.

I'm not talking about inflammative or toxic/oxidative food but I don't think long term anti-inflammatory is consensually a sound strategy for increasing lifespan. After all in most cases autoimmunity is supposedly useful.

However you should at least take everyday potent antioxidants to increase your lifespan/healthspan.

Essentially Skq1 + nac coadministred.

SkQ1 is the discovery of the century but it needs nac to cancel its ironically prooxidative effect on mitochondria bioenergetics.