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Small-Scale Question Sunday for December 14, 2025

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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Anyone wanna share their peptides/supplements stack that actually does something? My current stack (aside from very basic stuff like Vitamin D):

  • Omega-3 for skin, inflammation, cognition - made a difference for my skin, not sure about anything else, make sure to get high quality one
  • Magnesium Glycinate for sleep - makes it easier to fall asleep, and helps with not feeling dead on wake up on nights when I don't get enough sleep
  • Selank: for anxiety, mood regulation, depression - genuinely makes me feel more happy and stable. I've been going through cycles of rumination, depression and mild panic attacks at night and they've pretty much stopped. I still get negative thoughts at night here and there, but instead of automatically falling into a negative feedback loop I can just observe the thought and move on. This is my first cycle of selank, so not sure how it's gonna go in the future but I'm very surprised to see such noticeable changes, usually with stuff like this changes are marginal.
  • Creatine: had to stop this one for now, but it's great for the gym. I've been reading research on 10gr dose providing visible cognitive benefits, so I will try that instead of 5gr to see if it makes a difference next time I can hop on it.

Semaglutide for weight-loss and energy.

I've gotten off the horse for megadosing on Fisetien for Reasons(and I really need to get back on) but it remains the one supplement I should never give up simply because every time I megadose at the start of the month, my reaction can vary wildly - from nothing at all to sleepy lethargy as if I'm fighting off an infection to voracrious hunger to - well, you get the picture. It's an odd supplement that always makes me raise an eyebrow.

Creatine is something I'll sample occasionally, and is basically rocket-fuel for training. I tend to use it sparingly, as it's obvious effects wear off pretty quickly.