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What's going on here? A hat tip to the crazies who really want to use it despite lack of evidence, or has The Science changed, and I should pray they do not alter it any further?
I’m still not seeing evidence that it works, much less that it’s a “silver bullet.”
2021: literature review as of the Delta variant finds null effect, albeit with “low confidence”. Taiwanese authors.
2021: meta-analysis finds no clinical benefits with “moderate” confidence. Brazilian authors.
2022: Another Brazilian study and meta-analysis. No significant effect on outpatients.
2023: No significant effect. Most recent meta-analysis that I’ve found. American lead authors.
2023: Indian RCT (n = 594) finds insignificant effect. This was the most recent individual research I found with a casual search.
I don’t think anything has upturned the consensus. Sites are still reporting that HCQ doesn’t work and may also make you poop yourself. Not sure why Mayo has a different line; perhaps they’re just hedging?
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