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PaperclipPerfector  1mo ago (text post)   1583 thread views

Wellness Wednesday for July 15, 2026

The Wednesday Wellness threads are meant to encourage users to ask for and provide advice and motivation to improve their lives. It isn't intended as a 'containment thread' and any content which could go here could instead be posted in its own thread. You could post:

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As far as I'm aware, there's nothing to be gained by taking time off GLP-1 drugs. They're not tolerance forming. They're not habit forming either.

On the contrary, the last paper I recall reading said that people gained back 2/3rds of the lost weight within a year, probably in the context of semaglutide. I've heard people say that this is a knock against it, which is pants-on-head retarded. Most drugs stop working when you don't take them. It's not an antibiotic (which you hopefully don't need by the time you stop the course).

Agreed.

For GLP-1s, if you don't taper off the dosage and replace the hyperpalatable foods in your house with decent stuff while you have the temporary self-control, you'll gain the weight back. Has nothing to do with the drug and everything to do with the individual.

"Temporary self-control" implies it gives me discipline or something. It doesn't. The best way I can describe it is it's 9:30am and I just finished my morning standup meeting or whatever and although the idea of going out for a latte and having a croissant may pop into my head just the same, but there's no hit of dopamine that makes me put my shoes on and head out the front door unless I exert an enormous amount of willpower to stop it. Instead the thought is just an idea with no urgency.

It's not even a struggle. Quite the opposite. It would actually be a struggle to go out and eat despite, since the thought of eating when I'm not actively hungry is so boring.

I would love to believe this is reprogramming me, but I wouldn't be surprised if missing a few weeks of doses brings the urgency behind those intrusive food thoughts back.

I've taken GLP-1s for a single dose so I know exactly what you're describing. It led me to having smaller portions for 3-4 months. I've now backslid a bit and had to come up with more exercise to compensate.

That first hit is the best.

This is how I feel on keto. Even just a couple of days with very low carbs and no sugar takes me from "3/4 of a pizza" guy to "did I remember to eat once today, or twice?"

They're not tolerance forming.

How does that square with the fact that you need to keep increasing the dose (albeit not forever)?

I started on a very low dose myself (<1mg) but am having to increase it because my weight loss is plateauing.

Because you keep asking for more weight loss?

To make up numbers:

Let's say x amount of semaglutide suppresses appetite to a degree that accounts for y kg of lost weight for the average person. They plateau there.

Then they want to lose more weight, and go on to take take 2x of the drug and lose 2y of the weight before plateauing again.

That... is the least surprising thing I can imagine. It would be bad if there wasn't a reliable dose-response curve, or if a single dose of a GLP-1 agonist meant that you lose your appetite completely. We aren't trying to induce total anorexia.

It would be something entirely different if you had lost Y weight on X, and then notice that while you're on your regular dose, the weight crept up. That is not impossible, but it is not typical either. That phenomenon would invite questions about tolerance at a physiological level.

Agreed! Anyone who has actually lost weight through diet and or exercise knows full. well you also regain the weight when you stop doing it. So I don't consider this a knock against the drugs either, they are miracle drugs because they are infinitely easier to tolerate and, I don't know about anyone else, but whenever I've lost substantial amounts of weight from dieting and exercise, I feel fucking hungry all the time and really tired and miserable. There's no "maintaining" that isn't suffering. whereas I just don't on GLPs

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