VoiceOfLogic
I happen to be, unfortunately, the first human super-intelligence.
What a sad tragedy to see what others can't see.
User ID: 1999
This is what you want https://play.google.com/store/apps/details?id=net.daylio&hl=fr&gl=US&pli=1
I also advise you to use the xmind zen mindmap
Now about depression, the thing that has always scared me is that there are vicious cycles but the same is true for virtuous cycles.
I have a very extensive expertise in psychopharmacology and yet I can tell you the things that will have the most impact on your well being are:
good and sufficient sleep hygiene, increase your sleep duration, for that you can start listening to ASMR made for sleep.
fight loneliness at all cost, you need to see your friends frequently
listen to music that give you joy for example you might surprise yourself dancing in front of a mirror with https://youtube.com/watch?v=cD5TrBtiCsM and https://youtube.com/watch?v=BNig6xG36i4&t=15s
improve your hobbies e.g. start reading a great book
do regular physical exercise it is a decent complementary antidepressant although not as much as sleep and environnemental enrichment https://en.wikipedia.org/wiki/Environmental_enrichment
Something easy to achieve is to pay a gamepass pc subscription and play games with your friends such as e.g. Worms
Now pharmacologically speaking
daily vitamin D at 3000 IU is an effective antidepressant benign contrary to the classical ones
there are other benign not officially considered antidepressants with complementary action mechanisms such as ALCAR e.g. 1000 per day
more generally checking your health biomarkers including hormones can help, e.g. TRT or fight a deficiency, e.g. taking selenium 200mcg everyday (not more) can improve your health and lifespan and depression if the depression stems from some health related deficits.
About traditional antideps, they mostly have semi serious side effects, the only mostly benign ones with statistically reasonable effectiveness are the RIMA (not a MAOI) moclobemide and the melatonin agonist agomelatine. Always check CYP inhibition concerns with other coadministrated drugs or supplements. Do not trust doctors to do those checks for you, they do not know how to do their job and this is systemic.
Do not obsess about medication, it can help some but for most lifestyle and consistent mindset changes are both sufficent and effective.
Good luck dear human, it gets better :)
I feel frankly good in my life right now btw
VoiceOfLogic
2yr ago
This is the brazilian state of the art https://youtube.com/watch?v=ZxGiEoczryg&t=2932s
VoiceOfLogic
2yr ago
Thx, I haven't done physics in a while :)
VoiceOfLogic
2yr ago
Nice
VoiceOfLogic
2yr ago
Sorry english is not my native language so it can rarely albeit sometimes be ambiguous to me, by "I support"
do you mean that's your job? Or do you mean that you are a philanthropist that sponsor original research in pharmacology?
I have an extreme interest in maximizing lifespan/healthspan, you should look for example into mitochondria targeted antioxidants.
Note that this ideal is an artificially enhanced look that exploit supra-normal stimulus and androgynousity, for example the brows are very masculine albeit supra-masculine.
https://www.edge.org/response-detail/27203
It is an interesting feature that for women to exert peak visual stimulation they require for some feature to reach levels more masculine than men themselves.
VoiceOfLogic
2yr ago
Thanks
VoiceOfLogic
2yr ago
Just saying:
installing software dependencies to run it is very simple you can learn it in 15 minutes.
It depends on the environment but e.g. for the popular Javascript command line applications you need to install the Javascript virtual machine (NodeJs), it will install for you Npm, the node package manager which allow you to install dependencies.
You git clone a JS repository you find cool.
you run npm install
and to run the app it depends, could be npx run or npm run/serve, but that detail is described in the Readme file of the github repository see section how to install/run
For other programming languages, the steps are very similar and straigthforward.
IIRC Chinese ships were capable of long range exploration? They would more have been bottlenecked by a lack of investment and especially by a non-colonialist/deshumanizing culture
e.g. Chinese went to sommalia a century before the europeans https://en.wikipedia.org/wiki/Chinese_exploration#/media/File:ShenDuGiraffePainting.jpg
The question is, could they have done it much earlier? When exactly did they developed such ships technology?
But there are much more potent historic anachonisms, such as the Indo-greek kingdom https://en.wikipedia.org/wiki/Indo-Greek_Kingdom
or the fact greeks went in the Xinjiang, China
What is less known is if those anachronic explorers managed to do knowledge/technology/culture/artefact transfers.
https://en.wikipedia.org/wiki/Chronology_of_European_exploration_of_Asia
The radhanites seems remarkably interesting https://en.wikipedia.org/wiki/Radhanite
VoiceOfLogic
2yr ago
I might do it if I find the motivation, we'll see..
Great topic, I am very much into YouTube channels with unique proposition values, one that is remarkably great is https://youtube.com/watch?v=pDW4IYVlbbw
I am also in sapiosexual love with Vihart, the mathemusician, possibly the most brilliant woman on youtube, if not on earth
Throughout the decade I have been able to find the ultimate artists though, such as the unique masterpiece that is Umami's Interface
https://youtube.com/watch?v=b_V-VJQT6pM
And the vocally unique: The Minute Hour
Thanks Cafe, that is a great comment, exactly the kind of informatively rich comments the motte desperately lacks.
I will give you a proper answer tomorrow but when I said that tryptophan cross the BBB, I actually meant about 5 hydroxy tryptophan (5htp), which has good bioavailability, cross the BBB and bypass the rate limiting enzyme conversion of L-tryptophan to 5htp (which itself downstream will again be converted to serotonin in a rate limited manner)
1998:
VoiceOfLogic
2yr ago
If true this probably imply that concerned ethnic minorities are more likely to responds more potently to nootropics such as e.g. cholinergics. A result I have not yet found through serendipity search, IMO I can't even answer wether women benefit more from nootropics (except for testosterone) but at least it is vastly known people with lower IQ in general, (even more so if specific condition such as fragile X syndrome) and non-young people are much higher responders.
VoiceOfLogic
2yr ago
IQ is positively correlated with virtually every social metric there is.
I midly agree a-priori although too high intelligence can make someone incompatible with others (see inferential distance) and make someones become too serious, I believe hyperintellectualism reduce abilities to produce humor/jokes.
But isn't the common belief that very high IQ people are contingently but empirically correlated with cognitive disorders such as e.g the autism/asperger spectrum?
VoiceOfLogic
2yr ago
It only takes one powerful real civilization to create millions, billions of ancestor-simulations. We should conclude that most pre-singularity civilizations exist in simulation.
I wish this argument would be true.
It is unfortunately inept however, have you any idea of the energy and computing power needed to simulate a universe? Have you any idea of the energy and computing power needed to simulate a bottle of water at the atomic level? A single cell ? We can barely exhaustively study quantum systems with more than 2 particles IIRC
The universe has finite resources and the constraints of mathematics are universal or even meta-universal and so is https://en.wikipedia.org/wiki/Computational_complexity your hypothetical aliens must bends to those extreme limits. Even mankind has already mostly reached them, we have extreme diminishing returns everywhere.
VoiceOfLogic
2yr ago
Right although some glasses have nice to have distortions such as a loop effect that makes your eyes appear larger than they are.
You can always wear contact lenses if that annoys you and optionally change the color of your eyes or make them appears reptile or feline like :)
VoiceOfLogic
2yr ago
Including muscles?
You are talking about an hypothetical blunting.
Would they also develop an increased interest to a particular feature/stimuli?
Maybe feminine ones?
Unmedicated ADHD types who can summon hyper-focus semi-reliably
Happy to see it mentioned.
Note however that i have unmedicated ADD and the few times I tried amphetamines it enhanced my hyperfocusing obsessive ability instead of decreasing it.
An effect that seems logical, since it give me more energy (which I chronically lack) and make thinking/reading even more pleasant.
VoiceOfLogic
2yr ago
The idea of doing an opposite mechanism to fight a given toxicity is trivial and indeed a good one in theory.
People have a fuzzy understanding when they talk about inflammation though.
One would be symptoms of exogenous toxicity such as indeed oxidative stress. But that is not per se what inflammation denote, it denotes an autoimmune toxic but potentially useful reaction, mostly mediated via some Interleukins, TNF and IFN.
I'm not talking about inflammative or toxic/oxidative food but I don't think long term anti-inflammatory is consensually a sound strategy for increasing lifespan. After all in most cases autoimmunity is supposedly useful.
However you should at least take everyday potent antioxidants to increase your lifespan/healthspan.
Essentially Skq1 + nac coadministred.
SkQ1 is the discovery of the century but it needs nac to cancel its ironically prooxidative effect on mitochondria bioenergetics.
VoiceOfLogic
2yr ago
walking is, it seems, a unique nootropic and socializer: https://news.ycombinator.com/item?id=28354769
VoiceOfLogic
2yr ago
No, of course, I didn't litterally mean that there isn't a smartest human on earth (although here I specifically mean maximal debiasing, not about other heterogeneous cognitive abilities), there is one by design, however my point was that human being is sadly not significantly above the other ones in the top. In fact they're quite mediocre and most must reach a deceiving plateau.
VoiceOfLogic
2yr ago
What is the legal identity criterion of textual copyright?
E.g. Let's say you wrote a book.
I take it and change one word.
Is it still your book or is it now mine or public domain?
2 words?
100 words?
Is there a percentage?
Does the location matter?
If i change words mostly at the start of the book or throughout it?
Does semantics matters? Can i via a software replace some words by identical synonyms or do i need to change semantics?
I have no clue how the legal system solves this major problem.
I would probably enforce the use of
the sota in https://paperswithcode.com/sota/semantic-textual-similarity-on-sts-benchmark and set a magic number percentage. Although it can be gamed that's probably much more accurate than whatever is being used now.
Indeed that is a nice heuristic but I feel if this was true for past geniuses (e.g. Euler) however this should be less and less true.
Mathematics have reached a plateau and for all matters has been replaced via the curry Howard correspondence by computer science and software engineering and to some extent machine learning.
There are very few important open problems left and the ones that are left are either non-computable, non provable or false, or are long known, conjectured to be true but can't be proven for all cases because of contrived details.
And that is what mathematics are increasingly, an interest in deeply contrived things.
Many of those contrivations are contingencies, but there's also a lot that shouldn't even exist in the first place under a proper finitist framework.
Do you see genius in the last major proofs?
IIRC what has allowed the Poincaré conjecture millennium prize to be solved for all cases even the many contrived ones, has "simply" or at least essentially been a new way to bruteforce the problem, essentially via a specific software made for it.
Most of the genius we attribute to mathematics is a derivation of a few factors:
-
Obscurantism as a culture, especially elite notations for denoting trivial things. Notation which mostly have no IDE support btw.
-
as said lack of IDE tooling/culture
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the desire of having fun/ideology such as rejecting finitism. See e.g rational trigonometry. There is a semi-similar parallel with the quantum physics culture.
-
many historical accidents which alter how we teach maths.
Learning data structures and algorithms in computer science should be enough for someone to demysticize mathematics.
Mathematics have changed the world for the better and many of its concepts are useful for a rationalist mind's, however I'm afraid the lack of non-contrived nor real-world impacting challenges combined with the semi-anti intellectual/contrived culture would limits/bottleneck someone intellectual development instead of strengthening it, as a life main occupation.
Of course this is only a generalization.
Note however that regardless of that, fields medals are like Nobel prizes, a weak signal since they do a very poor job at representing who drove the most progress in a question and only show, allegedly, the last person in the problem solving chain.
IIRC the Russian that solved the millennium problema didn't reject the monetary prize because he was hermit weirdo as depicted by some medias, but as a political act since he didn't deserved most of the recognition.
I have read over 1000 Russian/USSR studies in pharmacology.
The Russian medical research is not the only one to be an isolated island, this apply also to Japanese research for example, see e.g their research on tinnitus.
While it is true that Russian research in pharmacology is understudied by the west, because of criminal mediocrity, there are many counter examples of Russian counpounds that have a decent amount of international research.
See e.g the biggest discovery in medecine of the century: skq1.
IIRC for Russian pharmaceuticals, the international researchers I "often see" study them are Indian or Brazilian. Maybe German too.
As for Nootropics or geroprotectors, they are generally markedly more ignored by the international "community" because of systemic failures, since nootropics/cognition enhancement are not considered a legitimate drug target and therefore is underfunded. Except for the niche research on mitigating fragile X syndrome, autism, the negative symptoms of schizophrenia, social anxiety, etc.
Since USSR and to some extent Russian research is public funded they are almost the only one in the world to afford fundamental research at scale of targets that have no commercial value in the prescription drug market.
As for geroprotectors the same apply, Ageing is generally not considered a disease, nor something that should be treated by taking pharmacology because we live in a very infantile/stockholmised world.
Even though geroprotectors often have partial efficacy against a wide range of lucrative diseases, the extreme inertia and cost of clinical trials combined to the extreme aversion of doctors for polypharmacology, partial drugs and simply keeping up with medical advance when it is evolitive instead of being disruptive explain that they are underresearched by the west and never prescribed.
The Russian also afford something revolutionary, they study the pharmacological application of drug that are plant/animal derived or that are endogenously produced in the human body (e.g. Peptides).
Those entire class of pharmacologicals, which have a billion of year of existence and bidirectional fine tuning, and ideal side effects profile are in general not patentable and since mostly only corporations fund clinical trials, the main class of medecine is in practice, non-existent because of broken incentives.
Because the Russian bypass those attractors/repulsors that plague the medical research, they can and do make revolutionary discoveries in most fields of medicine.
As i said, many Russian counpounds do have multiple international research that reproduce and corroborate the potency of their results.
However it is true that there is a concern of fraud/amplifying the potency of the effect of a pharmaceutical.
In my experience such fraud is rare but is possible.
The main candidate I have is the atypical anxiolytic Tofisopam.
Not Russian though, but from an ex USSR European state.
I have read the 300s studies about it.
There is IIRC a lot of corroborating studies from around the world, Including recent studies.
Tofisopam is an atypical anxiolytic, antidepressant, non addictive gabaergic, dopaminergic and generally excitatory drug as is is an atypical selective PDE inhibitor.
It is the only drug in the world to have this pharmacological profile and can be expected to have widespread, unique effects.
The body of studies for its action mechanisms are many and are very convincing in principle.
I am not rejecting the research on the nature of its effects.
Tofisopam is extremely interesting and that is not a fraud per se.
However I am rejecting the extreme amount of studies showing very potent effects on depression, anxiety, schizophrenia and other psychological conditions.
While the effect is real and tofisopam might be used for those conditions, how can there be so many studies corroborating very potent results while the actual reported effect online is very mild/inconsistent is a mystery for me.
Even though the online reports are rare and it might be that tofisopam truly is a wonder drug, IMHO I doubt it.
How can it be fraud when there is so much research from different teams and decade, even international one ?
Just look at how potent tofisopam is supposed to be https://fr.scribd.com/presentation/328205226/Tofisopam-Medical-2014-REVISED
A fraud at this scale can't be explained.
It would be too risky to synchronize such a massive amount of fraudulent researchers. Among the 300s studies not a single one significantly dismiss the rest of the research.
But if the reported potency of tofisopam is really a fraud then that is horrific for the rest of the medical research, nothing could be trusted as even a compound with so many studies, over decades and many international teams, for so many conditions would not be immune to consistent, systematic international fraud.
Honestly the endogenous endocannabinoid system is the only neurotransmitter I haven't rigorously studied (along with sigmaergy) but IIRC THC has many neurotoxic effects and can lead to both reduced synaptic plasticity and anhedonia induced by e.g. depleted dopamine https://www.frontiersin.org/articles/10.3389/fpsyt.2021.623403/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123717/ Of course like for 90% of drugs the major causative factor of toxicity must be related to oxidative stress and therefore this damage can be prevented, the interesting question being what are the other mechanisms and causes of thc toxicity? There are however mixed effects IIRC e.g. thc has neurotrophic effects too? annectodically, I don't have much IRL experience with thc but when I did I noticed a strong nocitropic/brain fog effect. But there might be a sweet spot with lower doses?
other things I remember: CB2 is fairly useless as a psychotrope
oleamide is a weird endocannabinoid which induced strong insomnia in me (paradoxal effect given research, I wonder what this denote about my brain)
there are other cannabinoid receptors than CB1 and CB2 but the research on them is very scarce
There are altenatives to thc, such as Delta 8 which has the merit to be less anxiogenic.
IIRC direct agonists lead to too fast tolerance and are considered dangerous versus the PAMs, however IIRC there are some new synthethic with claims of being viable so?
The toxicity of the alternative allosteric modulators (PAMs) such as delta 8 is understudied but IMO is likely not much stronger than thc unless they create currently unknown toxic metabolites. Their toxicity "should" be proportional to their dose potency relative to thc but alas the reddit evidence is that most lead to slighly-to highly faster tolerance buildup than thc and tolerance buildup is a not too shitty measure of toxicity, despite potency relative normalization.
The same hold true for many research stims btw, for very unclear and underresearched scientific reasons not are all the same bargain on the homeostatic response strength.
btw another thing strongly understudied is the effects and cross tolerance mechanisms of thc combination with dopaminergics and noradrenergics. btw if anyone know the mechanisms of thc induced tachychardia, I'm interested besides, is there an equivalent to MAOIs for CB1?
BTW anyone know a decent subreddit or forum to discuss pharmacology, that isn't related to nootropics?
Also when someone will wake the fuck up and synthethize mesocarb as a legal stim? https://en.wikipedia.org/wiki/Mesocarb
I need to ask the ukrainian
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