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PaperclipPerfector  8d ago (text post)   26040 thread views

Culture War Roundup for the week of July 28, 2025

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While the Sweeney jeans add is clearly an overreaction to fake eugenics downthread, it does seem like real, hard, embryo selection eugenics is here, or at least right around the corner. Scott Alexander's article released yesterday, Suddenly, Trait-Based Embryo Selection, says:

In 2023, Orchid Health entered the field. Unlike Genomic Prediction, which tested only the most important genetic variants, Orchid offers whole genome sequencing, which can detect the de novo3 mutations involved in autism, developmental disorders, and certain other genetic diseases.

Critics accused GP and Orchid of offering “designer babies”, but this was only true in the weakest sense - customers couldn’t “design” a baby for anything other than slightly lower risk of genetic disease. These companies refused to offer selection on “traits” - the industry term for the really controversial stuff like height, IQ, or eye color. Still, these were trivial extensions of their technology, and everybody knew it was just a matter of time before someone took the plunge.

Last month, a startup called Nucleus took the plunge. They had previously offered 23andMe style genetic tests for adults. Now they announced a partnership with Genomic Prediction focusing on embryos. Although GP would continue to only test for health outcomes, you could forward the raw data from GP to Nucleus, and Nucleus would predict extra traits, including height, BMI, eye color, hair color, ADHD, IQ, and even handedness.

The gist of the article is that while the science is still in its infancy and there are a lot of challenges to overcome, these companies are not just selling vaporware. There's real embryo selection based on traits happening, that is going to be significant for babies being born now.

Of course this article is just another confirmation of science fiction becoming reality, but it's still shocking to see from my perspective. You'd think we would at least have a discussion as to whether this should be legal or not, but unfortunately given how crippled out legislative apparatus is, tech companies continue to just push ahead with zero fear of regulatory change. They're willing to take the risk.

Now I personally have religious reasons to oppose this sort of intervention, but even if you don't, it's not hard to imagine the insane societal consequences of allowing free for all designer babies. As one hyperbolic comment on the slate star subreddit says:

Yet another reason for people to not have kids.

This shit is so socially erosive. "Want a baby? Do you want a prole baby, made the old fashioned way? You don't know what you're going to get! It's like a loot box, could be pure crap. You should PAY US to make a cool designer baby, with a 34% increased chance of the ultra-rare and coveted phenotype High Functioning Autist. If you have a loot box baby, they're going to get crushed by Ultra-Rare HFA Baby"

Nuke it from orbit.

While this comment is pretty over the top, I still think there's a strong point here! Gattaca was a cautionary tale, not a user's manual. Then again, I suppose the general zeitgeist considers the prole class to be so whipped, and coddled with bread and circuses, that our materialistic transhumanist tech overlords can simply do whatever they want, even if it will end up condemning "natural-born" people to permanent servitude.

The culture war lines here would've been pretty clear a while ago, but now it's muddled. Will the religious right be able to turn their coalition against this? Will the left see this as inequality on steroids? Will an uneasy alliance be made to ban this technology from the light of day? Only time will tell.

I don’t really see why this is bad. You have to to put in perspective, which is that we are in a full blown race against genetic meltdown in the gene pool. Genetic mutational load is cumulative! That means deleterious mutations continue down the germ line! In layman’s terms: We are breeding people to be dumber and weaker and sicker at an alarmingly fast rate. Why shouldn’t we equip people to fight this trend? It’s like, our only effective tool at this point

Idk generally biodiversity is a strength for life and gene editing ourselves to be more similar and eliminate mutations opens up some long term danger. Even just monocultures without same genetics but same species clumped up too much in an area can end up wiped out.

Now with gene editing technology perhaps we'll avoid the issues because we can literally just edit ourselves to not die to a new disease, but that's gonna depend on how much we can do and how fast we can do it.

I think it's perfectly fair at least to worry that planned genetics might have an unexpected issue the same way planned economies did. Easy to think you outsmarted the greater systems of the world until it bites you in the ass.

Do the genes that code for immune system responses also tend to be the ones that have a big effect on polygenic scores for eg, intelligence? If not, I'm really not too worried about these selected embryos being dangerously similar to one another

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