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Small-Scale Question Sunday for October 4, 2026

Do you have a dumb question that you're kind of embarrassed to ask in the main thread? Is there something you're just not sure about?

This is your opportunity to ask questions. No question too simple or too silly.

Culture war topics are accepted, and proposals for a better intro post are appreciated.

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Is anyone monitoring the biological attack in Russia?

Nope. I have Indian wholesale antibiotics and recently got a second cat, I think the plague is irrelevant to me.

It’s a gain-of-function enhanced bioweapon version of pneumatic plague. The stock version naturally has a 90% fatality rate. 77% if you can get them on antibiotics less than a day after infection. This one has probably been bred or engineered to be resistant to most major antibiotics. There’s also some indications it’s been modified to have a longer-non-symptomatic carrying period to compensate for the high fatality rate.

Is it a lab leak or a bioweapon attack from Ukraine? What's your best guess about this whole thing?

Multiple sources are saying that the index case was a worker at a lab known to have stocks of plague bacteria. So as close to smoking gun evidence of a lab leak as you are going to get in an authoritarian country.

Pneumonic plague is a rare natural variant of bubonic plague caused by the same Y pestis bacterium - I see no evidence that the variant we are seeing has been the subject of gain of function research (or that it wasn't, but a leak of unmodified plague is more likely even if some of the work being done at the Irkutsk lab was GoF). Weaponisation research on plague could include aerosolising (non-GoFed) plague bacteria in a way which would consistently generate the (more deadly and more transmissible) pneumonic form - a lab leak outbreak where the index case was pneumonic would be strong circumstantial evidence that this was happening.

To do weaponisation research on GoFed Y pestis (as opposed to doing the GoF work and the weaponisation work separately) would be an act of such monumental stupidity that I don't expect even the Russians to do it.

As I understand, if you get it from inhaling vapors from a broken vial, it'd be 100% pneumonic. One gets the bubonic one via an infected insect bite, and the way of ingress defines how it goes - if it's the bite, it goes to the closest lymph node, settles there and you have a bubo. If it's inhaled, it settles in the lungs, thus pneumonic. You don't need to modify anything between one and the other, it's just how it got in that matters.