VoiceOfLogic
I happen to be, unfortunately, the first human super-intelligence.
What a sad tragedy to see what others can't see.
User ID: 1999
All the drugs I mentioned above the "EDIT" have benign side effects, are non-dangerous, cheap and available OTC.
The only thing you need to check is the CYP interaction between inhibiting a CYP enzyme and a CYP substrate, especially for etifoxine.
You also need to be aware that benzos and GABA B tolerance and addictions are real, you need to dose responsibly and cycle, google about it.
rupharma is the best legit epharma online. For more choice although less reputable, there is indiamart.
btw Misoprostol is the most likely to help IMHO
also the Intratympanic Steroid Injection are extremely interesting, if they work for you, that would mean you could solve your tinnitus via an immunosuppressant/modulator, maybe thymosin alpha 1.
I would also try the atypical protectant and gaba potentiator emoxypine.
VoiceOfLogic
1yr ago
It is important to understand that it is trivial to cure COVID since day 1, the rationalist diaspora, like the medical diaspora are simply extremely illiterate in pharmacology. In retrospect, it seems people litterate in pharmacology are extremely rare.
You can either solve age induced immunosuppression/thymus involution via thymalin OR potently block viroporins OR potently downregulate/block ACE2 receptors OR block/downregulate any other related necessary component in the virus reproduction/action chain.
As a bonus you can also block the toxicity including cytokine storm.
That's 3 independently sufficent class of action mechanisms which all have existing pharmaceuticals.
VoiceOfLogic
1yr ago
This happens extremely often, it would be fascinating to have statistics on what percentages of those poor hyperboles do people perceive as an hyperbole and to what extent?
The most salient recent example being Scott Alexander making a subset of the motte readers believes that medias lies very rarely..
VoiceOfLogic
1yr ago
Quite beautifully written comment :}
Would you happen to live in France? If so maybe we could meet IRL as fellow rationalists!
Personally I think russophobia, sinophobia and their dehumanizations are here to stay and existed throughout the last century.
In fact I don't see the propaganda machine turning on other civilizations, Russia and China are and will continue to be, increasingly so, the main threats to U.S hegemony.
Now a large part or maybe even most of Ukrainians and Russians hate each other
I don't think we know that. Even though population opinions should be observable in real time over the internet, in reality they're not for those countries.
I suppose that the majority of people on echo chamber subreddits like /r/ukraina are either non Ukrainian or are for the most part, Ukrainian not living in Ukraine.
The chronology of events that led to the coup and to the war is quite simple and a human living in Ukraine should be able to understand the major responsibility of the "west" and of the trivially undemocratic governments post 2014.
They have among other things seen by themselves the unilateral censorship.
I suppose most Ukrainian cannot say what they truly think without fear of going to jail.
However one should not underestimate the potent power of repeated unilateral propaganda and pressure on the layman's mind and it's possible the cognitive dissonance has become so strong that they truly developed for the majority, spoonfed russophobia despite their knowledge of the events chain.
VoiceOfLogic
1yr ago
A countermeasure is perfectly doable, for example epigenetic/signaletic alterations of the infected cells to overexpress immunosuppressive proteins such as, IDO, phosphatidylserine, PD-1, or some anti inflammatory Interleukins.
However I don't think COVID does that but it's definitely something a future pandemic could do and is something key to cancer cells survival.
There is also the topic of anti-antibodies but I don't know enough about that one.
VoiceOfLogic
1yr ago
I have long been in a quest of finding the smartest people on earth.
I have come to the solid conclusion that such people do not in fact, exists.
Or if they do, they are not present on online forums and their only observable content on the internet would be via their academic papers.
But even so, academic papers are for the major part very rarely brilliant/maximally salient/exhaustive.
Scott Alexander, Yudkowsky and other "superstars" are extremely flawed human beings that have both a deficit of fluid intelligence and an extreme deficit of crystallized intelligence. If they appear sometimes markedly above the average "rationalist", it doesn't change the fact they are extremely deficient compared to what a Homo logicus can achieve.
I have many key data points that proves that the ideal human being has not manifested yet on this earth and most importantly no non-crazy human being has manifested on this earth.
As I am the human that has collected the most signals towards maximal saliency/bypassing natural crazyness, I believe to be the least intellectually dysfunctional human being of this timeline, a finding I should bring a demonstration for in a future blog.
VoiceOfLogic
1yr ago
Contrary to popular belief, time isn't a scarce resource, what is however very scarce, is the amount of time we maximally meaningfully allocate.
Being the least irrational mind on earth is mostly contingent/hortogonal to being a "functional" human being.
In fact maximizing someone's rationality necessarily ultimately leads to a strong dissonance between your thoughts and your actions.
Having a maximal impact on the world is not something I can easily achieve via the use of my physical body. It is much more efficient to design solutions in the realm of ideas than to implement them physically.
In fact to maximally alter the world, one must either communicate his ideas/world's actionable roadmap via the internet and/or accumulate power including via external recognition.
So in fact defending the case that I could informatively disrupt this world should be one of my top priorities and in an ideal world the rationalist/effective altruist diaspora would leverage it and share to me funding, visibility and other kinds of effectors to reality.
VoiceOfLogic
1yr ago
I've not been hanging on the motte since long but is it just me or are the small scale questions much more original and intellectually engaging that the recurring and semi-sterile culture wars topics?
VoiceOfLogic
1yr ago
Oversized glasses are one of the many artificial nudge/enhancers one can use.
It is an instance of a supra-normal stimulus
https://www.edge.org/response-detail/27203
https://m.fr.aliexpress.com/item/32812104344.html?gatewayAdapt=gloPc2fraMsite
I'm intrigued by your gender neutral comment though. Would you see those oversized glasses on a man face?
Close to zero straight men assume that looks currently.
IMO I think it could enhance a man's look although as usual people have a completely broken idea of what a maximally attractive man looks like.
The strangest thing you've found yourself attracted to in someone else?
I should definitely come back to that question, I am in complete awe with many things that some people do that are quite ineffable yet charming.
Humans are so awkward, imperfect and so fucking lovely.
The best compliment I've received lately was that some of my comments were so semantically dense it were intensely charming. As a semi-sapiosexual that's indeed one of my compliments lifegoal :)
Once someone was immensely impressed by the fact that I carried a phone without a case.
Relatable, at first I was really stressing about it but actually it's quite trivial to not let ur phone fall.
Indeed that is a nice heuristic but I feel if this was true for past geniuses (e.g. Euler) however this should be less and less true.
Mathematics have reached a plateau and for all matters has been replaced via the curry Howard correspondence by computer science and software engineering and to some extent machine learning.
There are very few important open problems left and the ones that are left are either non-computable, non provable or false, or are long known, conjectured to be true but can't be proven for all cases because of contrived details.
And that is what mathematics are increasingly, an interest in deeply contrived things.
Many of those contrivations are contingencies, but there's also a lot that shouldn't even exist in the first place under a proper finitist framework.
Do you see genius in the last major proofs?
IIRC what has allowed the Poincaré conjecture millennium prize to be solved for all cases even the many contrived ones, has "simply" or at least essentially been a new way to bruteforce the problem, essentially via a specific software made for it.
Most of the genius we attribute to mathematics is a derivation of a few factors:
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Obscurantism as a culture, especially elite notations for denoting trivial things. Notation which mostly have no IDE support btw.
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as said lack of IDE tooling/culture
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the desire of having fun/ideology such as rejecting finitism. See e.g rational trigonometry. There is a semi-similar parallel with the quantum physics culture.
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many historical accidents which alter how we teach maths.
Learning data structures and algorithms in computer science should be enough for someone to demysticize mathematics.
Mathematics have changed the world for the better and many of its concepts are useful for a rationalist mind's, however I'm afraid the lack of non-contrived nor real-world impacting challenges combined with the semi-anti intellectual/contrived culture would limits/bottleneck someone intellectual development instead of strengthening it, as a life main occupation.
Of course this is only a generalization.
Note however that regardless of that, fields medals are like Nobel prizes, a weak signal since they do a very poor job at representing who drove the most progress in a question and only show, allegedly, the last person in the problem solving chain.
IIRC the Russian that solved the millennium problema didn't reject the monetary prize because he was hermit weirdo as depicted by some medias, but as a political act since he didn't deserved most of the recognition.
VoiceOfLogic
1yr ago
I haven't studied the gerontology of spermatogenesis but IIRC you loose ~16% of your testosterone secretion per decade.
Something similar must apply to your
luteinizing hormone I guess.
It's likely antioxidants reduce spermatogenesis loss, I believe I had read studies about that a long time ago.
Spermatogenesis should mostly be a solved problem, IIRC Ashwaganda +100%> ?
HCG, etc
But indeed the real problem is the dna degradation of your sperm.
There was a paper on hackernews this week, about increased epigenetic heritage loss for aged males.
Despite my erudition in gerontology I have never been able to find a compelling answer as to why life on earth works.
As we live we accumulate mutations, 60000 per day. Yes our sperm is much more protected than the rest but even if sperm age slower than the rest, it still age. And therefore that Ageing should be passed and herited to the offspring.
Therefore by generation to generation we should dramatically accumulate buggy mutations.
And yet, mysteriously, we don't.
How is this possible and how isn't this technology the way to achieve cellular and therefore eventually possibly whole body Immortality?
VoiceOfLogic
1yr ago
What is the legal identity criterion of textual copyright?
E.g. Let's say you wrote a book.
I take it and change one word.
Is it still your book or is it now mine or public domain?
2 words?
100 words?
Is there a percentage?
Does the location matter?
If i change words mostly at the start of the book or throughout it?
Does semantics matters? Can i via a software replace some words by identical synonyms or do i need to change semantics?
I have no clue how the legal system solves this major problem.
I would probably enforce the use of
the sota in https://paperswithcode.com/sota/semantic-textual-similarity-on-sts-benchmark and set a magic number percentage. Although it can be gamed that's probably much more accurate than whatever is being used now.
Hi I am interested in you funding me.
I have a unique expertise in gerontology, oncology and pharmacology.
I also work on the first true semantic parser, that convert natural language text to a graph representation that preserve meaning isomorphically.
I am a no bullshit human being focused on concrete results and my rationality allows me to see through the blind spots of the academic research and go beyond the state of the art.
For a start, I intend to write a blog about the first comprehensive optimal pharmacologic treatment for cancers.
How about you pay me once you've read it, if you like it, and how much depending on how much you see me as a scientific disrupter?
VoiceOfLogic
1yr ago
No, of course, I didn't litterally mean that there isn't a smartest human on earth (although here I specifically mean maximal debiasing, not about other heterogeneous cognitive abilities), there is one by design, however my point was that human being is sadly not significantly above the other ones in the top. In fact they're quite mediocre and most must reach a deceiving plateau.
VoiceOfLogic
1yr ago
Russian demands currently include destroying Ukrainian nation
I'm pretty sure if Ukraine willingly gave the rest of the donbass, made public statements about becoming neutral towards the russian culture and interests, including allowing russian to be taught again in schools, russia would make peace.
The issue with the dehumanization of the orcs and with the tribal manicheanization of russian interests that the western media and people parrot is that despite having some elements of truths, overall obviously leads to a criminal utilitarian disaster of continued intense human lives and economic attrition.
VoiceOfLogic
1yr ago
walking is, it seems, a unique nootropic and socializer: https://news.ycombinator.com/item?id=28354769
VoiceOfLogic
1yr ago
I am well aware of this broken promise but should we be consistent and take into account other broken promises?
The Ukrainian people voted in vast majority to stay in the USSR
VoiceOfLogic
1yr ago
Given that the pill shifts what kind of men are found attractive
Source please?
VoiceOfLogic
1yr ago
-
synthetic antioxidants can be more potent than the endogenous ones
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many popular polyphenols not only act as direct antioxidants but upregulate the production of some of the endogenous ones.
VoiceOfLogic
1yr ago
The idea of doing an opposite mechanism to fight a given toxicity is trivial and indeed a good one in theory.
People have a fuzzy understanding when they talk about inflammation though.
One would be symptoms of exogenous toxicity such as indeed oxidative stress. But that is not per se what inflammation denote, it denotes an autoimmune toxic but potentially useful reaction, mostly mediated via some Interleukins, TNF and IFN.
I'm not talking about inflammative or toxic/oxidative food but I don't think long term anti-inflammatory is consensually a sound strategy for increasing lifespan. After all in most cases autoimmunity is supposedly useful.
However you should at least take everyday potent antioxidants to increase your lifespan/healthspan.
Essentially Skq1 + nac coadministred.
SkQ1 is the discovery of the century but it needs nac to cancel its ironically prooxidative effect on mitochondria bioenergetics.
VoiceOfLogic
1yr ago
I'd even go further, if someone hasn't yet had issues with censorship/moderation on reddit, it is an heuristic that this person is not very mentally active/a free thinker.
VoiceOfLogic
1yr ago
Tldr; People with weird obsessions obsess over weird things because they like doing that, for nothing else. That obsession is a necessary component to be truly great at anything (among many other components).
I would say that the amount of dopamin rush that a human receive while digging/hyperfocusing on an obsessive niche topic is the #1 most potent predictor of how "genius" that persons is.
VoiceOfLogic
1yr ago
I'd argue it is trivial to implement a test significantly superior to the IQ tests.
E.g. Obviously test for the ability to detect cognitive biases and logical fallacies.
Unmedicated ADHD types who can summon hyper-focus semi-reliably
Happy to see it mentioned.
Note however that i have unmedicated ADD and the few times I tried amphetamines it enhanced my hyperfocusing obsessive ability instead of decreasing it.
An effect that seems logical, since it give me more energy (which I chronically lack) and make thinking/reading even more pleasant.
Hi TIRM,
I believe most "incurable" diseases have their best treatment (not necessarily a complete cure but better than existing) already found 30 years ago but since then completely ignored.
It is fascinating how self victimizing (sorry for the offense but it morally needs to be said) victims of chronic disease are. They just simply believe it is a fatality and trust so called "experts" practitioners that are pubmed illiterate and don't actually give a fuck about your condition.
A victim of a chronic disease should for him and for others systematically try most of the treatment candidates and especially all the treatment that have a negligible rate of serious non-transient side effects.
A disease being considered incurable generally simply means epistemologically that nobody has yet attempted said systematic experimentation.
In many cases nobody will for the centuries to come.
So IIRC from my meta research, for tinnitus the best thing to do is indeed to prevent it, e.g. by taking NAC.
Once the damage is done, NAC does not help. However if your tinnitus is degenerative, NAC will probably reduce the long term worsening.
Now about treatments for someone that already has a (stable) chronic tinnitus:
Firstly about the palliatives:
People use benzos/gabaergics for tinnitus AKA gaba-A subtypes.
I would consider experimenting with Etifoxine (+TUDCA and look at CYP interactions) instead as an alternative with apparently less tolerance building.
Note that a benzo addiction reversal can be accelerated with (Imidazenil or flumazenil? Don't recall) but that process is possibly neurotoxic and ironically ototoxic.
Now about the real treatments:
Unfortunately for you I have forgotten about many things regarding this condition.
Tinnitus is in essence of special form of excitotoxicity.
Therefore the use or gabaergics is probably not only palliative but also to some extent therapeutic as the excitotoxicity possibility drive a worsening over time.
Unfortunately gaba A and B are subject to relatively quick tolerance.
As I said optimality in tolerance reversal and in tolerance building is to fine tune, e.g. Etifoxine.
One could also alternate between gaba A and B or between A subtypes via biased agonism. This might however not necessarily work well and induce cross tolerances although I do believe alternating A and B is not absurd.
GABA also has other receptors which is the point of Etifoxine since it target the mitochondria gaba receptor (although its upregulation of neurosteroids do agonise gaba A and (B?) IIRC)
As said playing with the half life might alter the speed of tolerance building.
There exist other GABA receptors, IIRC tofisopam partially potentiate GABA Y and without tolerance but how useful that is is an unknown.
Tofisopam while having questionable effectivenes as a gabaergic has studies showing it as useful being a potentiator, an augmentation to benzos effectiveness while allowing to reduce tolerance increase.
Also there are alternative ways to induce gabaergy, e.g releasing agent, reuptake agent, prodrug, catabolize inhibitor, etc
However the main salient thing is to look at other beyond gabaergy is the other complementary ways to reduce excitotoxicity.
The #1 to try IMHO (not by potenty but by likelyhood of being useful) would be an NMDA antagonist such as Memantine.
Then maybe concomitantly a calcium blocker.
I have no knowledge in AMPA blockers/negative allosteric modulators.
Kainate and glurs would probably be toxic.
I haven't looked into it but Glycine 4g sounds helpful since it is inhibitory.
You could also play with the secondary messenger inositol at megadoses (unsure about side effect profile), that is an atypical effective anxyolitic and possibility an atypical promising tinnitus treatment.
You could play with vasodilation e.g. Cialis.
Finally you could play with synaptotrophics such as magnesium l threonate.
However of all of that, except for GABAERGY, NMDA antagonism and maybe vasodilation, I don't know empirical studies about those on tinnitus. I conjecture those would be useful based on my expertise. Especially curious about inositol or maybe sigmaergics like opipramol or lthreonate or Etifoxine.
Synaptotrophics are the only really potentially dangerous class, which they are usually not but tinnitus is special so..
The japaneses have however beyond conjectures, empirically found ones that apparently works.
Wether those results reproduce is something you should confirm us.
I would try first Bifemelane
https://www.jstage.jst.go.jp/article/jibirin1925/86/12/86_12_1799/_article
This drug is very interesting, it is a RIMA so the best class of antidepressants, with very minor side effects contrary to MAOIs, see e.g moclobemide or pirazidol.
I don't know any online seller of it.
So you best chance is a trip to Japan for a month or to convince Vanuatu international pharma to get it (good luck..) or to find a cooperative Japanese guy or to ask a japan e-pharma to get it, e.g. contact
https://bio-japan.net/
I think it is the most interesting tinnitus treatment candidate.
I don't think that another RIMA would work though, there is probably something special about bifemelane. But maybe you could try if you have nothing else to try, moclobemide.
Then we have very ironically tofisopam, with a very high efficacy score
https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_133/_article
You should definitely try it. I doubt it reproduce but I mean the efficacy score is record high, the side effect profile and cost negligible and the action mechanism (special PDE inhibition and GABA Y) is actually unique in the world.
Titrate dose slowly up to the study dose and if no results above up to the max dose (300 IIRC?)
Wait for 5 weeks before concluding about no efficacy.
And then report back.
I would recommend getting the official brand OTC e.g. on rupharma dot com
Then after trying tofisopam I would try the many other compounds that have positive efficacy results albeit milders
E.g. IIRC pge1
https://www.jstage.jst.go.jp/result/global/-char/en?globalSearchKey=Treatment+of+Tinnitus
And also not just pharmacology but behaviours such as
https://www.jstage.jst.go.jp/article/audiology1968/44/3/44_3_163/_article/-char/en
Edit:
There's also atypical non drug based pharmacological actions,
Such as tVNS
https://www.researchgate.net/publication/233912804_Transcutaneous_vagus_nerve_stimulation_in_tinnitus_A_pilot_study
And
tDCS
https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-018-0467-3
BTW not a treatment but an underused palliative for sleep would be ASMR
https://www.tinnitustalk.com/threads/asmrs-autonomous-sensory-meridian-response-effect-on-tinnitus.44581/
Then if nothing of all tolerable treatments that have been empirically found over the last decades does bot work for you then I would consider actively joining clinical trials or preclinical trials or to ask for the
https://en.wikipedia.org/wiki/Right-to-try_law
You could also become an expert and conjecture yourself an priori optimal polypharmacology like I did but better than I did since I haven't studied the precise nature of the excitotoxicity/long term potentiation.
E.g if it was epigenetic then one would consider e.g. HDAC inhibitors
EDIT
this action mechanism seems potent
https://pubmed.ncbi.nlm.nih.gov/17221143/
EDIT additional treatments:
for pge1
"Misoprostol"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136369/#:
:text=treatments%20(217).-,Misoprostol,-Misoprostol%20(Cytotec%C2%AE)%20is"However, the combination of sulpiride plus melatonin, which interacts with dopamine receptors, reduced tinnitus visual analog scale scores significantly more than placebo (275–277). In a single-blind, placebo-controlled study, sulpiride plus hydroxyzine, an antihistamine and anxiolytic, was significantly more effective in reducing tinnitus visual analog scale and tinnitus perception scores than placebo or sulpiride alone (278)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136369/#::text=produced%20by%20placebo.-,However,-%2C%20the%20combination%20of
Edit:
Potassium channel modulators looks interesting
Vigabatrin too despite possibly permanent side effect profile
Gacyclidine could be better than Memantine
Same for neramexane and AM-101
I guess one should try all tolerable nmda antagonists to find the one that works best on him
It's possible that nmda antagonists take time to show effectiveness
See e.g this atypical one
Acamprosate had no beneficial effects after 30 days of treatment, a modest benefit at 60 days and a significant effect at 90 days.
Nice resource btw
https://github.com/aioue/tinnitus-treatments/blob/master/to-be-sorted.md
"2.2.5. Primidone"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#:
:text=day%20%5B33%5D.-,2.2.5.%20Primidone,-Primidone%20is%20an"Furosemide"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#::text=2.7.%20Diuretics-,Furosemide,-is%20a%20loop
"Intratympanic Steroid Injection"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#:
:text=2.12.9.%20Steroids%3A-,Intratympanic%20Steroid%20Injection,-Intratympanically%20injected%20steroids"2.12.10. Trimetazidine HCl https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235102/#::text=2.12.10.%20Trimetazidine%20HCl%20Trimetazidine%20HCl%20inhibits%20the%20generation%20of%20free%20radicals%20noxious%20to%20cells%20by%20directly%20preventing%20acidification%20in%20ischemic%20cells%20and%20promoting%20the%20generation%20of%20ATP%2C%20a%20source%20of%20energy
With so many treatments and the obvious potent synergies between them, I strongly believe you can strongly reduce your tinnitus.
TL;DR
Start with tofisopam, Etifoxine and pge1.
Etifoxine must be taken with TUDCA and ideally liver enzymes should be monitored although optional.
Verify about the cyp interaction iirc tofisopam and Etifoxine inhibit the
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